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  "sourcesContent": ["import{jsx as e,jsxs as t}from\"react/jsx-runtime\";import{addPropertyControls as o,ControlType as a,Link as s}from\"framer\";import*as n from\"react\";let c=\"uWllLCBtA\",r=\"RcqFeuKTS\",i=\"KFfcvAWx6\",l=\"EdMDQpCW9\",m=\"niCUG1HBm\",h=\"ULkYzozq6\",p=\"WpCdrTjq8\",d=\"R1uixPKw2\",g=\"KEW0qayWg\",w=\"M5uSyNKWZ\",u=\"s6iPLbBrP\",f=\"hY3kD0cwp\",y=(e,t)=>{if(e&&\"object\"==typeof e)return{...e,alt:t};},b=[{id:\"QyRSQ__V3\",[c]:\"An Updated Etiology of Hair Loss and the New Cosmeceutical Paradigm in Therapy: Clearing \u2018the Big Eight Strikes\u2019.\",[r]:\"Nicholas Sadgrove, David Barreto, Jeff Rapaport, Sanjay Batra\",[i]:\"Cosmetics\",[l]:\"3.3\",[m]:\"2023\",[h]:\"https://www.mdpi.com/2079-9284/10/4/106\",[p]:\"big-eight-strikes\",[d]:y({src:\"https://framerusercontent.com/images/3fJXiXwIZsVZ6pNJrE7GJPLilQ.png\",srcSet:\"https://framerusercontent.com/images/3fJXiXwIZsVZ6pNJrE7GJPLilQ.png?scale-down-to=512 512w, https://framerusercontent.com/images/3fJXiXwIZsVZ6pNJrE7GJPLilQ.png?scale-down-to=1024 1024w, https://framerusercontent.com/images/3fJXiXwIZsVZ6pNJrE7GJPLilQ.png 1716w\"},\"\"),[g]:y({src:\"https://framerusercontent.com/images/ryFryLEdqk5NsAWRYFhyOntEE.jpg?scale-down-to=4096\",srcSet:\"https://framerusercontent.com/images/ryFryLEdqk5NsAWRYFhyOntEE.jpg?scale-down-to=512 341w, https://framerusercontent.com/images/ryFryLEdqk5NsAWRYFhyOntEE.jpg?scale-down-to=1024 682w, https://framerusercontent.com/images/ryFryLEdqk5NsAWRYFhyOntEE.jpg?scale-down-to=2048 1365w, https://framerusercontent.com/images/ryFryLEdqk5NsAWRYFhyOntEE.jpg?scale-down-to=4096 2730w, https://framerusercontent.com/images/ryFryLEdqk5NsAWRYFhyOntEE.jpg 3333w\"},\"\"),[w]:y({src:\"https://framerusercontent.com/images/TbsxCTO33YDNVDZxmKKUoGJhNtA.jpg?scale-down-to=4096\",srcSet:\"https://framerusercontent.com/images/TbsxCTO33YDNVDZxmKKUoGJhNtA.jpg?scale-down-to=512 512w, https://framerusercontent.com/images/TbsxCTO33YDNVDZxmKKUoGJhNtA.jpg?scale-down-to=1024 1024w, https://framerusercontent.com/images/TbsxCTO33YDNVDZxmKKUoGJhNtA.jpg?scale-down-to=2048 2048w, https://framerusercontent.com/images/TbsxCTO33YDNVDZxmKKUoGJhNtA.jpg?scale-down-to=4096 4096w, https://framerusercontent.com/images/TbsxCTO33YDNVDZxmKKUoGJhNtA.jpg 4500w\"},\"\"),[u]:y({src:\"https://framerusercontent.com/images/syH9RLxTM8PdwFUOSHAI0TtYx8A.jpg?scale-down-to=4096\",srcSet:\"https://framerusercontent.com/images/syH9RLxTM8PdwFUOSHAI0TtYx8A.jpg?scale-down-to=512 341w, https://framerusercontent.com/images/syH9RLxTM8PdwFUOSHAI0TtYx8A.jpg?scale-down-to=1024 682w, https://framerusercontent.com/images/syH9RLxTM8PdwFUOSHAI0TtYx8A.jpg?scale-down-to=2048 1365w, https://framerusercontent.com/images/syH9RLxTM8PdwFUOSHAI0TtYx8A.jpg?scale-down-to=4096 2730w, https://framerusercontent.com/images/syH9RLxTM8PdwFUOSHAI0TtYx8A.jpg 3333w\"},\"\"),[f]:/*#__PURE__*/e(n.Fragment,{children:/*#__PURE__*/e(\"p\",{children:\"In this current review, research spanning the last decade (such as transcriptomic studies, phenotypic observations, and confirmed comorbidities) has been synthesized into an updated etiology of hair loss and applied to the new cosmeceutical paradigm of hair rejuvenation. The major etiological components in scalps with hair loss are denoted as the \u2018big eight strikes\u2019, which include the following: androgens, prostaglandins, overactive aerobic metabolism of glucose, bacterial or fungal over-colonization, inflammation, fibrosis, metabolism or circulation problems, and malnutrition. The relevance of the \u2018big eight\u2019 to nine categories of hair loss is explained. In cases of androgenetic alopecia or female pattern hair loss, both elevated DHT and increased frequency of androgen receptors lead to problems with the metabolism of glucose (sugar), redox imbalance, disruption to the electron transport chain, and PPAR-\u03B3 overactivity (the latter is unique to androgenetic alopecia, where the reverse occurs in other types of hair loss). These etiological factors and others from \u2018the big eight\u2019 are the focal point of our hypothetical narrative of the attenuative mechanisms of commercial cosmeceutical hair serums. We conclude that cosmeceuticals with the potential to improve all eight strikes (according to published in vitro or clinical data) utilize bioactive peptides and plant compounds that are either flavonoids (isoflavones, procyanidins, flavanols, and flavonols) or sterols/triterpenes. It is noteworthy that many therapeutic interventions are generic to the multiple types of hair loss. Lastly, suggestions are made on how scalp and hair health can be improved by following the cosmeceutical approach.\"})})},{id:\"DpuJgbAhB\",[c]:\"The \u2018bald\u2019 phenotype (androgenetic alopecia) is caused by the high glycaemic, high cholesterol and low mineral \u2018western diet\u2019.\",[r]:\"Nicholas Sadgrove\",[i]:\"Trends in Food Science and Technology\",[l]:\"15.3\",[m]:\"2021\",[h]:\"https://www.sciencedirect.com/science/article/abs/pii/S0924224421004362\",[p]:\"the-bald-phenotype\",[d]:y({src:\"https://framerusercontent.com/images/u8hNRaoW3ukjxv3Nw8nJlbwU1oM.png\",srcSet:\"https://framerusercontent.com/images/u8hNRaoW3ukjxv3Nw8nJlbwU1oM.png?scale-down-to=512 512w, https://framerusercontent.com/images/u8hNRaoW3ukjxv3Nw8nJlbwU1oM.png?scale-down-to=1024 1024w, https://framerusercontent.com/images/u8hNRaoW3ukjxv3Nw8nJlbwU1oM.png 1678w\"},\"\"),[g]:y({src:\"https://framerusercontent.com/images/61X2E6PT0QsUA36v3qmaeKqSBzE.jpg?scale-down-to=4096\",srcSet:\"https://framerusercontent.com/images/61X2E6PT0QsUA36v3qmaeKqSBzE.jpg?scale-down-to=512 512w, https://framerusercontent.com/images/61X2E6PT0QsUA36v3qmaeKqSBzE.jpg?scale-down-to=1024 1024w, https://framerusercontent.com/images/61X2E6PT0QsUA36v3qmaeKqSBzE.jpg?scale-down-to=2048 2048w, https://framerusercontent.com/images/61X2E6PT0QsUA36v3qmaeKqSBzE.jpg?scale-down-to=4096 4096w, https://framerusercontent.com/images/61X2E6PT0QsUA36v3qmaeKqSBzE.jpg 6720w\"},\"\"),[w]:y({src:\"https://framerusercontent.com/images/89W8QsZzyuyZq66Hs2Aq3T7qlg.jpg?scale-down-to=4096\",srcSet:\"https://framerusercontent.com/images/89W8QsZzyuyZq66Hs2Aq3T7qlg.jpg?scale-down-to=512 512w, https://framerusercontent.com/images/89W8QsZzyuyZq66Hs2Aq3T7qlg.jpg?scale-down-to=1024 1024w, https://framerusercontent.com/images/89W8QsZzyuyZq66Hs2Aq3T7qlg.jpg?scale-down-to=2048 2048w, https://framerusercontent.com/images/89W8QsZzyuyZq66Hs2Aq3T7qlg.jpg?scale-down-to=4096 4096w, https://framerusercontent.com/images/89W8QsZzyuyZq66Hs2Aq3T7qlg.jpg 6709w\"},\"\"),[u]:y({src:\"https://framerusercontent.com/images/2wwenwevkUFPW9ZGLpfJATtcdM.jpg?scale-down-to=4096\",srcSet:\"https://framerusercontent.com/images/2wwenwevkUFPW9ZGLpfJATtcdM.jpg?scale-down-to=512 341w, https://framerusercontent.com/images/2wwenwevkUFPW9ZGLpfJATtcdM.jpg?scale-down-to=1024 682w, https://framerusercontent.com/images/2wwenwevkUFPW9ZGLpfJATtcdM.jpg?scale-down-to=2048 1365w, https://framerusercontent.com/images/2wwenwevkUFPW9ZGLpfJATtcdM.jpg?scale-down-to=4096 2730w, https://framerusercontent.com/images/2wwenwevkUFPW9ZGLpfJATtcdM.jpg 4480w\"},\"\"),[f]:/*#__PURE__*/t(n.Fragment,{children:[/*#__PURE__*/e(\"h3\",{children:\"Background\"}),/*#__PURE__*/e(\"p\",{children:\"The success of 5\u03B1-reductase inhibitors in the 1990s vindicated the role of androgens and cast doubt on the role of diet in androgenetic alopecia (AGA). However, poor glucose control and high cholesterol are now recognised as comorbidities, which are salient characters of the \u2018western diet\u2019.\"}),/*#__PURE__*/e(\"h3\",{children:\"Scope and approach\"}),/*#__PURE__*/t(\"p\",{children:[\"In glucose potentiated hair loss, continuous\\xa0\",/*#__PURE__*/e(s,{href:\"https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/monosaccharide\",openInNewTab:!1,smoothScroll:!1,children:/*#__PURE__*/e(\"a\",{children:\"monosaccharide\"})}),\"\\xa0flux to the liver promotes the\\xa0\",/*#__PURE__*/e(s,{href:\"https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/polyol-pathway\",openInNewTab:!1,smoothScroll:!1,children:/*#__PURE__*/e(\"a\",{children:\"polyol pathway\"})}),\", causing fatty liver and attenuating synthesis of\\xa0\",/*#__PURE__*/e(s,{href:\"https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/sex-hormone-binding-globulin\",openInNewTab:!1,smoothScroll:!1,children:/*#__PURE__*/e(\"a\",{children:\"sex hormone binding globulin\"})}),\", accommodating the increased ratio of dihydrotestosterone (DHT) to testosterone. The scalp of the balding phenotype is characterised by overactive PPAR-\u03B3 receptors, increased\\xa0\",/*#__PURE__*/e(s,{href:\"https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/fatty-acid-synthesis\",openInNewTab:!1,smoothScroll:!1,children:/*#__PURE__*/e(\"a\",{children:\"fatty acid synthesis\"})}),\", enlarged\\xa0\",/*#__PURE__*/e(s,{href:\"https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/sebaceous-gland\",openInNewTab:!1,smoothScroll:!1,children:/*#__PURE__*/e(\"a\",{children:\"sebaceous glands\"})}),\"\\xa0and\\xa0\",/*#__PURE__*/e(s,{href:\"https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/sebum-secretion\",openInNewTab:!1,smoothScroll:!1,children:/*#__PURE__*/e(\"a\",{children:\"sebum secretions\"})}),\". Sebum feeds lipophilic bacteria, such as\\xa0\",/*#__PURE__*/e(s,{href:\"https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/propionibacterium-acnes\",openInNewTab:!1,smoothScroll:!1,children:/*#__PURE__*/e(\"a\",{children:\"Propionibacterium acnes\"})}),\", which augment the expression of prostaglandin-type (PGD2\\xa0& 15d-PGJ2) ligands of PPAR-\u03B3 and increase local\\xa0\",/*#__PURE__*/e(s,{href:\"https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/insulin-sensitivity\",openInNewTab:!1,smoothScroll:!1,children:/*#__PURE__*/e(\"a\",{children:\"insulin sensitivity\"})}),\"\\xa0via Akt/mTOR pathways. In hyperglycaemic events the androgen dependent\\xa0\",/*#__PURE__*/e(s,{href:\"https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/polyol-pathway\",openInNewTab:!1,smoothScroll:!1,children:/*#__PURE__*/e(\"a\",{children:\"polyol pathway\"})}),\"\\xa0depletes glucose and generates\\xa0\",/*#__PURE__*/e(s,{href:\"https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/purine\",openInNewTab:!1,smoothScroll:!1,children:/*#__PURE__*/e(\"a\",{children:\"purine\"})}),\"\\xa0by-products that antagonise\\xa0\",/*#__PURE__*/e(s,{href:\"https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/adenosine-receptor\",openInNewTab:!1,smoothScroll:!1,children:/*#__PURE__*/e(\"a\",{children:\"adenosine receptors\"})}),\". Mitochondrial reactive oxygen species accumulate, and ATP levels reduce, slowing\\xa0\",/*#__PURE__*/e(s,{href:\"https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/gluconeogenesis\",openInNewTab:!1,smoothScroll:!1,children:/*#__PURE__*/e(\"a\",{children:\"gluconeogenesis\"})}),\"\\xa0in the outer root sheath\\xa0\",/*#__PURE__*/e(s,{href:\"https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/keratinocyte\",openInNewTab:!1,smoothScroll:!1,children:/*#__PURE__*/e(\"a\",{children:\"keratinocytes\"})}),\"\\xa0of the hair follicle. Furthermore, the current commentary suggests that an important mineral in hair health is magnesium, which is relevant to both glucose and cholesterol potentiated hair loss. Magnesium deficiency not only reinforces insulin resistance, but in cholesterol potentiated hair loss, local magnesium dependent\\xa0\",/*#__PURE__*/e(s,{href:\"https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/monooxygenase\",openInNewTab:!1,smoothScroll:!1,children:/*#__PURE__*/e(\"a\",{children:\"monooxygenase\"})}),\"\\xa0\",/*#__PURE__*/e(s,{href:\"https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/lysozyme\",openInNewTab:!1,smoothScroll:!1,children:/*#__PURE__*/e(\"a\",{children:\"enzymes\"})}),\"that metabolise cholesterol and\\xa0\",/*#__PURE__*/e(s,{href:\"https://www.sciencedirect.com/topics/food-science/vitamin-d\",openInNewTab:!1,smoothScroll:!1,children:/*#__PURE__*/e(\"a\",{children:\"vitamin D\"})}),\"\\xa0are impaired. Furthermore, magnesium deficient muscles at the occipital and temporal region of the skull create mechanical strain against the galea aponeurotica.\"]}),/*#__PURE__*/e(\"h3\",{children:\"Key findings and conclusions\"}),/*#__PURE__*/t(\"p\",{children:[\"Taking all of this into consideration, treatment options for androgenetic alopecia should include a low cholesterol and low\\xa0\",/*#__PURE__*/e(s,{href:\"https://www.sciencedirect.com/topics/food-science/glycemic-index\",openInNewTab:!1,smoothScroll:!1,children:/*#__PURE__*/e(\"a\",{children:\"glycaemic index\"})}),\"\\xa0diet, improved glucose control, and fortification with magnesium. Furthermore, the current narrative does not endorse severe caloric restriction for obvious health reasons.\"]})]})},{id:\"L8RzSQu18\",[c]:\"The new paradigm for androgenetic alopecia and plant-based folk remedies: 5\u03B1-reductase inhibition, reversal of secondary microinflammation and improving insulin resistance.\",[r]:\"Nicholas Sadgrove\",[i]:\"Journal of Ethnopharmacology\",[l]:\"5.4\",[m]:\"2018\",[h]:\"https://www.sciencedirect.com/science/article/abs/pii/S0378874118303325\",[p]:\"the-new-paradigm\",[d]:y({src:\"https://framerusercontent.com/images/4FBIG0F8r8bNqbYw7vYKmcnX3Y.png\",srcSet:\"https://framerusercontent.com/images/4FBIG0F8r8bNqbYw7vYKmcnX3Y.png?scale-down-to=512 512w, https://framerusercontent.com/images/4FBIG0F8r8bNqbYw7vYKmcnX3Y.png?scale-down-to=1024 1024w, https://framerusercontent.com/images/4FBIG0F8r8bNqbYw7vYKmcnX3Y.png 1716w\"},\"\"),[g]:y({src:\"https://framerusercontent.com/images/7fR23eBWE3nm50aoACk5FYHzyM8.jpg?scale-down-to=4096\",srcSet:\"https://framerusercontent.com/images/7fR23eBWE3nm50aoACk5FYHzyM8.jpg?scale-down-to=512 512w, https://framerusercontent.com/images/7fR23eBWE3nm50aoACk5FYHzyM8.jpg?scale-down-to=1024 1024w, https://framerusercontent.com/images/7fR23eBWE3nm50aoACk5FYHzyM8.jpg?scale-down-to=2048 2048w, https://framerusercontent.com/images/7fR23eBWE3nm50aoACk5FYHzyM8.jpg?scale-down-to=4096 4096w, https://framerusercontent.com/images/7fR23eBWE3nm50aoACk5FYHzyM8.jpg 8000w\"},\"\"),[w]:y({src:\"https://framerusercontent.com/images/rCtas19ITuxBGZgpH4EtPXjblc.jpg?scale-down-to=4096\",srcSet:\"https://framerusercontent.com/images/rCtas19ITuxBGZgpH4EtPXjblc.jpg?scale-down-to=512 512w, https://framerusercontent.com/images/rCtas19ITuxBGZgpH4EtPXjblc.jpg?scale-down-to=1024 1024w, https://framerusercontent.com/images/rCtas19ITuxBGZgpH4EtPXjblc.jpg?scale-down-to=2048 2048w, https://framerusercontent.com/images/rCtas19ITuxBGZgpH4EtPXjblc.jpg?scale-down-to=4096 4096w, https://framerusercontent.com/images/rCtas19ITuxBGZgpH4EtPXjblc.jpg 8000w\"},\"\"),[u]:y({src:\"https://framerusercontent.com/images/twOQIfpoZY5ogvK4RVyl0rUs7YY.jpg?scale-down-to=4096\",srcSet:\"https://framerusercontent.com/images/twOQIfpoZY5ogvK4RVyl0rUs7YY.jpg?scale-down-to=512 512w, https://framerusercontent.com/images/twOQIfpoZY5ogvK4RVyl0rUs7YY.jpg?scale-down-to=1024 1024w, https://framerusercontent.com/images/twOQIfpoZY5ogvK4RVyl0rUs7YY.jpg?scale-down-to=2048 2048w, https://framerusercontent.com/images/twOQIfpoZY5ogvK4RVyl0rUs7YY.jpg?scale-down-to=4096 4096w, https://framerusercontent.com/images/twOQIfpoZY5ogvK4RVyl0rUs7YY.jpg 8000w\"},\"\"),[f]:/*#__PURE__*/t(n.Fragment,{children:[/*#__PURE__*/e(\"h3\",{children:/*#__PURE__*/e(\"strong\",{children:\"Ethnopharmacological relevance\"})}),/*#__PURE__*/t(\"p\",{children:[\"Research in the past half a century has gradually sketched the biological mechanism leading to\\xa0\",/*#__PURE__*/e(s,{href:\"https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/male-type-alopecia\",openInNewTab:!1,smoothScroll:!1,children:/*#__PURE__*/e(\"a\",{children:\"androgenetic alopecia\"})}),\"\\xa0(AGA). Until recently the aetiological paradigm has been too limited to enable intelligent commentary on the use of folk remedies to treat or reduce the expression of this condition. However, our understanding is now at a point where we can describe how some folk remedies work, predict how effective they will be or why they fail.\"]}),/*#__PURE__*/e(\"h3\",{children:/*#__PURE__*/e(\"strong\",{children:\"Results\"})}),/*#__PURE__*/t(\"p\",{children:[\"The new paradigm of AGA is that inheritance and androgens (dihydrotestosterone) are the primary contributors and a secondary pathology, micro-inflammation, reinforces the process at more advanced stages of follicular miniaturisation. The main protagonist to microinflammation is believed to be microbial or\\xa0\",/*#__PURE__*/e(s,{href:\"https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/demodex\",openInNewTab:!1,smoothScroll:!1,children:/*#__PURE__*/e(\"a\",{children:\"Demodex\"})}),\"\\xa0over-colonisation of the infundibulum of the pilosebaceous unit, which can be ameliorated by antimicrobial/acaricidal or anti-inflammatory therapies that are used as adjuvants to androgen dependent treatments (either synthetic or natural). Furthermore, studies reveal that suboptimal androgen metabolism occurs in both AGA and insulin resistance (low\\xa0\",/*#__PURE__*/e(s,{href:\"https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/sex-hormone-binding-globulin\",openInNewTab:!1,smoothScroll:!1,children:/*#__PURE__*/e(\"a\",{children:\"SHBG\"})}),\"\\xa0or high DHT), suggesting comorbidity. Both can be ameliorated by dietary\\xa0\",/*#__PURE__*/e(s,{href:\"https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/phytochemical\",openInNewTab:!1,smoothScroll:!1,children:/*#__PURE__*/e(\"a\",{children:\"phytochemicals\"})}),\", such as specific classes of phenols (isoflavones, phenolic methoxy abietanes, hydroxylated anthraquinones) or polycyclic\\xa0\",/*#__PURE__*/e(s,{href:\"https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/triterpene\",openInNewTab:!1,smoothScroll:!1,children:/*#__PURE__*/e(\"a\",{children:\"triterpenes\"})}),\"\\xa0(sterols, lupanes), by dual inhibition of key enzymes in AGA (5\u03B1-reductase) and insulin resistance (ie., DPP-4 or PTP1B) or agonism of\\xa0\",/*#__PURE__*/e(s,{href:\"https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/cell-nucleus-receptor\",openInNewTab:!1,smoothScroll:!1,children:/*#__PURE__*/e(\"a\",{children:\"nuclear receptors\"})}),\"\\xa0(PPAR\u03B3). Evidence strongly indicates that some plant-based folk remedies can ameliorate both primary and secondary aetiological factors in AGA and improve insulin resistance, or act merely as successful adjuvants to mainstream androgen dependent therapies.\"]}),/*#__PURE__*/e(\"h3\",{children:/*#__PURE__*/e(\"strong\",{children:\"Conclusion\"})}),/*#__PURE__*/t(\"p\",{children:[\"Thus, if AGA is viewed as an outcome of primary and secondary factors, then it is better that a \u2018multimodal\u2019 or \u2018umbrella\u2019 approach, to achieve cessation and/or reversal, is put into practice, using complementation of chemical species (isoflavones,\\xa0\",/*#__PURE__*/e(s,{href:\"https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/anthraquinone\",openInNewTab:!1,smoothScroll:!1,children:/*#__PURE__*/e(\"a\",{children:\"anthraquinones\"})}),\",\\xa0\",/*#__PURE__*/e(s,{href:\"https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/procyanidin\",openInNewTab:!1,smoothScroll:!1,children:/*#__PURE__*/e(\"a\",{children:\"procyanidins\"})}),\",\\xa0\",/*#__PURE__*/e(s,{href:\"https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/triterpene\",openInNewTab:!1,smoothScroll:!1,children:/*#__PURE__*/e(\"a\",{children:\"triterpenes\"})}),\",\\xa0\",/*#__PURE__*/e(s,{href:\"https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/saponin\",openInNewTab:!1,smoothScroll:!1,children:/*#__PURE__*/e(\"a\",{children:\"saponins\"})}),\"\\xa0and\\xa0\",/*#__PURE__*/e(s,{href:\"https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/hydrogen-sulfide\",openInNewTab:!1,smoothScroll:!1,children:/*#__PURE__*/e(\"a\",{children:\"hydrogen sulphide\"})}),\"\\xa0prodrugs), thereby targeting multiple \u2018factors\u2019.\"]})]})},{id:\"YUPPLJ81Y\",[c]:\"Honest nutraceuticals, cosmetics, therapies, and foods (NCTFs): Standardization and safety of natural products.\",[r]:\"Nicholas Sadgrove\",[i]:\"Critical Reviews in Food Science and Nutrition\",[l]:\"10.2\",[m]:\"2022\",[h]:\"https://www.tandfonline.com/doi/full/10.1080/10408398.2021.1874286\",[p]:\"honest-nutraceuticals\",[d]:y({src:\"https://framerusercontent.com/images/J8bgbsmLMYmfmG7wBJGdZWiqtY4.png\",srcSet:\"https://framerusercontent.com/images/J8bgbsmLMYmfmG7wBJGdZWiqtY4.png?scale-down-to=512 512w, https://framerusercontent.com/images/J8bgbsmLMYmfmG7wBJGdZWiqtY4.png?scale-down-to=1024 1024w, https://framerusercontent.com/images/J8bgbsmLMYmfmG7wBJGdZWiqtY4.png 1716w\"},\"\"),[g]:y({src:\"https://framerusercontent.com/images/DuEocxHPhkJ4HRPVxKJMzDCgu8.jpg?scale-down-to=4096\",srcSet:\"https://framerusercontent.com/images/DuEocxHPhkJ4HRPVxKJMzDCgu8.jpg?scale-down-to=512 512w, https://framerusercontent.com/images/DuEocxHPhkJ4HRPVxKJMzDCgu8.jpg?scale-down-to=1024 1024w, https://framerusercontent.com/images/DuEocxHPhkJ4HRPVxKJMzDCgu8.jpg?scale-down-to=2048 2048w, https://framerusercontent.com/images/DuEocxHPhkJ4HRPVxKJMzDCgu8.jpg?scale-down-to=4096 4096w, https://framerusercontent.com/images/DuEocxHPhkJ4HRPVxKJMzDCgu8.jpg 4500w\"},\"\"),[w]:y({src:\"https://framerusercontent.com/images/oW82CPOLHbz2WA45isrvB5lEYHs.jpg?scale-down-to=4096\",srcSet:\"https://framerusercontent.com/images/oW82CPOLHbz2WA45isrvB5lEYHs.jpg?scale-down-to=512 341w, https://framerusercontent.com/images/oW82CPOLHbz2WA45isrvB5lEYHs.jpg?scale-down-to=1024 682w, https://framerusercontent.com/images/oW82CPOLHbz2WA45isrvB5lEYHs.jpg?scale-down-to=2048 1365w, https://framerusercontent.com/images/oW82CPOLHbz2WA45isrvB5lEYHs.jpg?scale-down-to=4096 2730w, https://framerusercontent.com/images/oW82CPOLHbz2WA45isrvB5lEYHs.jpg 3000w\"},\"\"),[u]:y({src:\"https://framerusercontent.com/images/UQCLXLcNbCOjgnra6oMTXKQuCI.jpg?scale-down-to=4096\",srcSet:\"https://framerusercontent.com/images/UQCLXLcNbCOjgnra6oMTXKQuCI.jpg?scale-down-to=512 341w, https://framerusercontent.com/images/UQCLXLcNbCOjgnra6oMTXKQuCI.jpg?scale-down-to=1024 682w, https://framerusercontent.com/images/UQCLXLcNbCOjgnra6oMTXKQuCI.jpg?scale-down-to=2048 1365w, https://framerusercontent.com/images/UQCLXLcNbCOjgnra6oMTXKQuCI.jpg?scale-down-to=4096 2730w, https://framerusercontent.com/images/UQCLXLcNbCOjgnra6oMTXKQuCI.jpg 3000w\"},\"\"),[f]:/*#__PURE__*/e(n.Fragment,{children:/*#__PURE__*/e(\"p\",{children:\"With the increasing demand for natural products by the consumer in the marketplace it is necessary to see a proportional increase in behind-the-scenes science to ensure that the ideology of safety and honesty, that is justifiably expected by the wider public, is adequately satisfied. It is of essence to have a fair yet firm governance of nutraceuticals, cosmetics, therapies, and foods. However, with increasing sophistications in adulteration and \u201Cclaim\u201D loopholes that make it easier for adulterated or counterfeited natural products to be \u201Cfudged\u201D to meet the pharmacopeia standards, governance protocols must utilize an \u201Cidentification and authentication\u201D approach that goes beyond the Pharmacopeia standards to help regulate and transparently communicate natural products in the commercial context. While it is becoming a rat race in keeping commercial natural products honest, modern technology can support authenticators and adequately defeat these challenges.\"})})}];for(let e of b)Object.freeze(e);o(b,{uWllLCBtA:{defaultValue:\"\",title:\"Title\",type:a.String},RcqFeuKTS:{defaultValue:\"\",placeholder:\"\",title:\"Authors\",type:a.String},KFfcvAWx6:{defaultValue:\"\",title:\"Journal\",type:a.String},EdMDQpCW9:{defaultValue:\"\",placeholder:\"\",title:\"Impact Factor\",type:a.String},niCUG1HBm:{defaultValue:\"\",title:\"Year\",type:a.String},ULkYzozq6:{title:\"Link\",type:a.Link},WpCdrTjq8:{title:\"Slug\",type:a.String},R1uixPKw2:{title:\"Thumbnail\",type:a.ResponsiveImage},KEW0qayWg:{title:\"Image 2\",type:a.ResponsiveImage},M5uSyNKWZ:{title:\"Image 3\",type:a.ResponsiveImage},s6iPLbBrP:{title:\"Image 4\",type:a.ResponsiveImage},hY3kD0cwp:{defaultValue:\"\",title:\"Abstract\",type:a.RichText}}),b.displayName=\"Portfolio\";export default b;export const enumToDisplayNameFunctions={};\nexport const __FramerMetadata__ = {\"exports\":{\"default\":{\"type\":\"data\",\"name\":\"data\",\"annotations\":{\"framerSlug\":\"WpCdrTjq8\",\"framerData\":\"\",\"framerRecordIdKey\":\"id\",\"framerContractVersion\":\"1\",\"framerEnumToDisplayNameUtils\":\"2\"}},\"enumToDisplayNameFunctions\":{\"type\":\"variable\",\"annotations\":{\"framerContractVersion\":\"1\"}},\"__FramerMetadata__\":{\"type\":\"variable\"}}}"],
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