{
  "version": 3,
  "sources": ["ssg:https://framerusercontent.com/modules/lgNoRVSbgz0pUmMUu0pP/JDtftqI7p7vRJi2lqZet/JmhujK3L9-3.js"],
  "sourcesContent": ["import{jsx as e,jsxs as t}from\"react/jsx-runtime\";import{Link as i}from\"framer\";import*as a from\"react\";export const richText=/*#__PURE__*/t(a.Fragment,{children:[/*#__PURE__*/e(\"p\",{children:/*#__PURE__*/e(\"em\",{children:/*#__PURE__*/e(\"strong\",{children:\"Advantages of Accelerated Aging\"})})}),/*#__PURE__*/t(\"ol\",{children:[/*#__PURE__*/e(\"li\",{\"data-preset-tag\":\"p\",children:/*#__PURE__*/t(\"p\",{children:[/*#__PURE__*/e(\"strong\",{children:\"Time Efficiency: \"}),\"Accelerated aging provides quick results, allowing manufacturers to make timely product formulations and packaging decisions.\"]})}),/*#__PURE__*/e(\"li\",{\"data-preset-tag\":\"p\",children:/*#__PURE__*/t(\"p\",{children:[/*#__PURE__*/e(\"strong\",{children:\"Cost-Effective:\"}),\" Reducing the duration of aging studies can lower costs associated with long-term storage and testing.\"]})}),/*#__PURE__*/e(\"li\",{\"data-preset-tag\":\"p\",children:/*#__PURE__*/t(\"p\",{children:[/*#__PURE__*/e(\"strong\",{children:\"Early Detection of Issues:\"}),\" Potential stability problems can be identified early, preventing costly recalls and ensuring consumer safety.\"]})}),/*#__PURE__*/e(\"li\",{\"data-preset-tag\":\"p\",children:/*#__PURE__*/t(\"p\",{children:[/*#__PURE__*/e(\"strong\",{children:\"Diagnosis of Known Problem:\"}),\" Finding the failing component that is limiting the product shelf life and changing the component to extend product usable shelf-life and increasing customer satisfaction\"]})})]}),/*#__PURE__*/e(\"p\",{children:/*#__PURE__*/e(\"em\",{children:/*#__PURE__*/e(\"strong\",{children:\"\\xa0\"})})}),/*#__PURE__*/e(\"p\",{children:/*#__PURE__*/e(\"em\",{children:/*#__PURE__*/e(\"strong\",{children:\"\\xa0Real-Time, Room Temperature Aging\"})})}),/*#__PURE__*/e(\"p\",{children:\"Real-time aging, as the name suggests, involves storing aerosol products at room temperature and observing their performance over an extended period. This method provides a more accurate representation of a product's behavior under normal storage conditions.\"}),/*#__PURE__*/e(\"p\",{children:/*#__PURE__*/e(\"em\",{children:/*#__PURE__*/e(\"strong\",{children:\"How Real-Time Aging is Conducted\"})})}),/*#__PURE__*/e(\"p\",{children:\"In real-time aging studies, products are kept in environments that mimic typical consumer storage conditions. These studies can span months or even years, depending on the product's expected shelf life. Researchers periodically test the products for changes in their physical, chemical, and performance characteristics.\"}),/*#__PURE__*/e(\"p\",{children:/*#__PURE__*/e(\"em\",{children:/*#__PURE__*/e(\"strong\",{children:\"Advantages of Real-Time Aging\"})})}),/*#__PURE__*/t(\"ol\",{children:[/*#__PURE__*/e(\"li\",{\"data-preset-tag\":\"p\",children:/*#__PURE__*/t(\"p\",{children:[/*#__PURE__*/e(\"strong\",{children:\"Accuracy: \"}),\"Real-time aging truly reflects how a product will age under normal conditions, offering the most reliable data.\"]})}),/*#__PURE__*/e(\"li\",{\"data-preset-tag\":\"p\",children:/*#__PURE__*/t(\"p\",{children:[/*#__PURE__*/e(\"strong\",{children:\"Comprehensive Data: \"}),\"This method captures all possible interactions and reactions over time, providing a complete picture of product stability.\"]})}),/*#__PURE__*/e(\"li\",{\"data-preset-tag\":\"p\",children:/*#__PURE__*/t(\"p\",{children:[/*#__PURE__*/e(\"strong\",{children:\"Regulatory Compliance:\"}),\" Some regulatory bodies require real-time aging data for product approval, making this method essential for market entry.\"]})})]}),/*#__PURE__*/e(\"p\",{children:/*#__PURE__*/e(\"em\",{children:/*#__PURE__*/e(\"strong\",{children:\"Comparing Accelerated and Real-Time Aging\"})})}),/*#__PURE__*/e(\"p\",{children:\"Both accelerated and real-time aging studies have their advantages and are often used in tandem to provide a comprehensive understanding of product stability. Accelerated aging is invaluable for rapid assessment and early detection of potential issues, while real-time aging offers the most accurate and reliable data for long-term stability.\"})]});export const richText1=/*#__PURE__*/e(a.Fragment,{children:/*#__PURE__*/e(\"p\",{children:/*#__PURE__*/e(\"em\",{children:\"Graph showing Example data for particle size vs. time for a consumer aerosol can.\"})})});export const richText2=/*#__PURE__*/t(a.Fragment,{children:[/*#__PURE__*/e(\"p\",{children:/*#__PURE__*/e(\"em\",{children:/*#__PURE__*/e(\"strong\",{children:\"ARE Labs' Capabilities in Aging Studies\"})})}),/*#__PURE__*/e(\"p\",{children:\"At ARE Labs, we specialize in conducting both accelerated and real-time aging studies for a wide range of consumer aerosol products. Our state-of-the-art facilities in Kansas are equipped with advanced temperature and humidity control systems, allowing us to create precise conditions for accelerated aging. Our real-time aging chambers also mimic typical consumer environments to provide the most accurate stability data.\"}),/*#__PURE__*/e(\"p\",{children:\"Our team of experts uses sophisticated analytical techniques to monitor changes in product properties over time, ensuring that your products meet the highest quality and safety standards. Whether you need quick insights through accelerated aging or comprehensive data through real-time studies, ARE Labs has the expertise and technology to support your product development and regulatory compliance needs.\"}),/*#__PURE__*/e(\"p\",{children:/*#__PURE__*/e(\"em\",{children:/*#__PURE__*/e(\"strong\",{children:\"Conclusion\"})})}),/*#__PURE__*/e(\"p\",{children:\"Aging studies are essential for ensuring the longevity and stability of consumer aerosol products. While accelerated aging offers quick and cost-effective insights, real-time aging provides the most accurate and reliable data. At ARE Labs, we are committed to providing comprehensive aging studies that help you bring safe and effective products to market. Contact us today to learn more about our capabilities and how we can assist with your aging study needs. \"})]});export const richText3=/*#__PURE__*/t(a.Fragment,{children:[/*#__PURE__*/e(\"p\",{children:\"Author: Saurabh Pathak, Ph.D.\"}),/*#__PURE__*/t(\"p\",{children:[\"A\",/*#__PURE__*/e(\"em\",{children:\"erosol Research and Engineering Labs Inc., Overland Park, Kansas 66213.\"})]}),/*#__PURE__*/e(\"p\",{children:/*#__PURE__*/e(\"strong\",{children:\"\\xa0\"})}),/*#__PURE__*/e(\"h5\",{children:/*#__PURE__*/e(\"strong\",{children:\"Introduction to Pulmonary Drug Delivery Studies\"})}),/*#__PURE__*/e(\"p\",{children:\"Pulmonary drug delivery is a method of administering medication directly into the lungs through inhalation. This route of delivery is particularly effective for treating respiratory conditions such as asthma, chronic obstructive pulmonary disease (COPD), and cystic fibrosis. It can also be used for systemic drug delivery, allowing medications to quickly enter the bloodstream. This article provides an overview of pulmonary drug delivery, its importance, the regulations governing its testing, and the types of tests involved.\"}),/*#__PURE__*/e(\"h5\",{children:/*#__PURE__*/e(\"strong\",{children:\"Why Pulmonary Drug Delivery Studies is Important\"})}),/*#__PURE__*/e(\"p\",{children:\"Pulmonary drug delivery offers several advantages over traditional drug delivery methods:\"}),/*#__PURE__*/t(\"ol\",{children:[/*#__PURE__*/e(\"li\",{\"data-preset-tag\":\"p\",children:/*#__PURE__*/t(\"p\",{children:[/*#__PURE__*/e(\"strong\",{children:\"Direct Delivery\"}),\": Medications are delivered directly to the site of action, increasing their effectiveness, and reducing systemic side effects.\"]})}),/*#__PURE__*/e(\"li\",{\"data-preset-tag\":\"p\",children:/*#__PURE__*/t(\"p\",{children:[/*#__PURE__*/e(\"strong\",{children:\"Rapid Onset\"}),\": Drugs administered via the lungs can quickly enter the bloodstream, providing rapid relief from symptoms.\"]})}),/*#__PURE__*/e(\"li\",{\"data-preset-tag\":\"p\",children:/*#__PURE__*/t(\"p\",{children:[/*#__PURE__*/e(\"strong\",{children:\"Non-Invasive\"}),\": This method is non-invasive, making it more comfortable for patients compared to injections.\"]})}),/*#__PURE__*/e(\"li\",{\"data-preset-tag\":\"p\",children:/*#__PURE__*/t(\"p\",{children:[/*#__PURE__*/e(\"strong\",{children:\"Lower Doses Required\"}),\": Because the medication is delivered directly to the lungs, lower doses are often needed, reducing the risk of side effects.\"]})})]}),/*#__PURE__*/e(\"h5\",{children:/*#__PURE__*/e(\"strong\",{children:\"Governmental Regulations for Pulmonary Drug Delivery Testing\"})}),/*#__PURE__*/e(\"p\",{children:\"Several governmental regulations and guidelines dictate the testing and approval of pulmonary drug delivery systems. These regulations ensure the safety, efficacy, and quality of the drug products:\"}),/*#__PURE__*/t(\"ol\",{children:[/*#__PURE__*/t(\"li\",{\"data-preset-tag\":\"p\",children:[/*#__PURE__*/t(\"p\",{children:[/*#__PURE__*/e(\"strong\",{children:\"U.S. Food and Drug Administration (FDA)\"}),\":\"]}),/*#__PURE__*/t(\"ul\",{children:[/*#__PURE__*/e(\"li\",{\"data-preset-tag\":\"p\",children:/*#__PURE__*/e(\"p\",{children:/*#__PURE__*/e(i,{href:\"https://www.ecfr.gov/current/title-21/chapter-I/subchapter-D/part-320\",nodeId:\"JmhujK3L9\",openInNewTab:!1,smoothScroll:!1,children:/*#__PURE__*/e(\"a\",{children:/*#__PURE__*/e(\"strong\",{children:\"21 CFR Part 320: Bioavailability and Bioequivalence Requirements\"})})})})}),/*#__PURE__*/e(\"li\",{\"data-preset-tag\":\"p\",children:/*#__PURE__*/e(\"p\",{children:/*#__PURE__*/e(i,{href:\"https://www.ecfr.gov/current/title-21/chapter-I/subchapter-D/part-314?toc=1\",nodeId:\"JmhujK3L9\",openInNewTab:!1,smoothScroll:!1,children:/*#__PURE__*/e(\"a\",{children:/*#__PURE__*/e(\"strong\",{children:\"21 CFR Part 314: Applications for FDA Approval to Market a New Drug\"})})})})}),/*#__PURE__*/e(\"li\",{\"data-preset-tag\":\"p\",children:/*#__PURE__*/e(\"p\",{children:/*#__PURE__*/e(i,{href:\"https://www.fda.gov/regulatory-information/search-fda-guidance-documents/metered-dose-inhaler-mdi-and-dry-powder-inhaler-dpi-drug-products-quality-considerations\",nodeId:\"JmhujK3L9\",openInNewTab:!1,smoothScroll:!1,children:/*#__PURE__*/e(\"a\",{children:/*#__PURE__*/e(\"strong\",{children:\"FDA Guidance for Industry: Metered Dose Inhaler (MDI) and Dry Powder Inhaler (DPI) Drug Products\"})})})})})]})]}),/*#__PURE__*/t(\"li\",{\"data-preset-tag\":\"p\",children:[/*#__PURE__*/t(\"p\",{children:[/*#__PURE__*/e(\"strong\",{children:\"European Medicines Agency (EMA)\"}),\":\"]}),/*#__PURE__*/t(\"ul\",{children:[/*#__PURE__*/e(\"li\",{\"data-preset-tag\":\"p\",children:/*#__PURE__*/e(\"p\",{children:/*#__PURE__*/e(i,{href:\"https://www.ema.europa.eu/en/pharmaceutical-quality-inhalation-nasal-products-scientific-guideline\",nodeId:\"JmhujK3L9\",openInNewTab:!1,smoothScroll:!1,children:/*#__PURE__*/e(\"a\",{children:/*#__PURE__*/e(\"strong\",{children:\"Guideline on the Pharmaceutical Quality of Inhalation and Nasal Products\"})})})})}),/*#__PURE__*/e(\"li\",{\"data-preset-tag\":\"p\",children:/*#__PURE__*/e(\"p\",{children:/*#__PURE__*/e(i,{href:\"https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX%3A02001L0083-20121116\",nodeId:\"JmhujK3L9\",openInNewTab:!1,smoothScroll:!1,children:/*#__PURE__*/e(\"a\",{children:/*#__PURE__*/e(\"strong\",{children:\"Directive 2001/83/EC: Community Code Relating to Medicinal Products for Human Use\"})})})})})]})]}),/*#__PURE__*/t(\"li\",{\"data-preset-tag\":\"p\",children:[/*#__PURE__*/t(\"p\",{children:[/*#__PURE__*/e(\"strong\",{children:\"International Council for Harmonization (ICH)\"}),\":\"]}),/*#__PURE__*/e(\"ul\",{children:/*#__PURE__*/e(\"li\",{\"data-preset-tag\":\"p\",children:/*#__PURE__*/e(\"p\",{children:/*#__PURE__*/e(i,{href:\"https://www.ema.europa.eu/en/ich-q6a-specifications-test-procedures-acceptance-criteria-new-drug-substances-new-drug-products-chemical-substances-scientific-guideline\",nodeId:\"JmhujK3L9\",openInNewTab:!1,smoothScroll:!1,children:/*#__PURE__*/e(\"a\",{children:/*#__PURE__*/e(\"strong\",{children:\"ICH Q6A: Specifications: Test Procedures and Acceptance Criteria for New Drug Substances and New Drug Products\"})})})})})})]})]})]});export const richText4=/*#__PURE__*/t(a.Fragment,{children:[/*#__PURE__*/e(\"h5\",{children:/*#__PURE__*/e(\"strong\",{children:\"Types of Tests for Pulmonary Drug Delivery\"})}),/*#__PURE__*/e(\"p\",{children:\"Pulmonary drug delivery studies involve various tests to ensure that the drug product meets all necessary standards for safety, efficacy, and quality. Some of the key tests include:\"}),/*#__PURE__*/t(\"ol\",{children:[/*#__PURE__*/t(\"li\",{\"data-preset-tag\":\"p\",children:[/*#__PURE__*/t(\"p\",{children:[/*#__PURE__*/e(\"strong\",{children:\"Aerodynamic Particle Size Distribution (APSD)\"}),\":\"]}),/*#__PURE__*/t(\"ul\",{children:[/*#__PURE__*/e(\"li\",{\"data-preset-tag\":\"p\",children:/*#__PURE__*/e(\"p\",{children:\"Determines the size of particles delivered by inhalation devices, which impacts the deposition of the drug in the lungs.\"})}),/*#__PURE__*/e(\"li\",{\"data-preset-tag\":\"p\",children:/*#__PURE__*/t(\"p\",{children:[/*#__PURE__*/e(\"strong\",{children:\"Cascade Impaction\"}),\": This technique uses a series of impaction stages to separate particles based on their aerodynamic diameter.\"]})}),/*#__PURE__*/e(\"li\",{\"data-preset-tag\":\"p\",children:/*#__PURE__*/t(\"p\",{children:[\" \",/*#__PURE__*/e(\"strong\",{children:\"Laser Diffraction\"}),\": This method measures the scattering pattern of a laser beam passed through an aerosol sample to determine particle size distribution.\"]})})]})]}),/*#__PURE__*/t(\"li\",{\"data-preset-tag\":\"p\",children:[/*#__PURE__*/t(\"p\",{children:[/*#__PURE__*/e(\"strong\",{children:\"Delivered Dose Uniformity (DDU)\"}),\":\"]}),/*#__PURE__*/t(\"ul\",{children:[/*#__PURE__*/e(\"li\",{\"data-preset-tag\":\"p\",children:/*#__PURE__*/e(\"p\",{children:\"Ensures that each dose delivered by the inhalation device is consistent in terms of the amount of drug.\"})}),/*#__PURE__*/e(\"li\",{\"data-preset-tag\":\"p\",children:/*#__PURE__*/t(\"p\",{children:[/*#__PURE__*/e(\"strong\",{children:\"Uniformity Testing\"}),\": This involves testing multiple doses from the same device to check for consistency.\"]})})]})]}),/*#__PURE__*/t(\"li\",{\"data-preset-tag\":\"p\",children:[/*#__PURE__*/t(\"p\",{children:[/*#__PURE__*/e(\"strong\",{children:\"Emitted Dose\"}),\":\"]}),/*#__PURE__*/t(\"ul\",{children:[/*#__PURE__*/e(\"li\",{\"data-preset-tag\":\"p\",children:/*#__PURE__*/e(\"p\",{children:\"Measures the amount of drug released from the inhalation device with each actuation.\"})}),/*#__PURE__*/e(\"li\",{\"data-preset-tag\":\"p\",children:/*#__PURE__*/t(\"p\",{children:[/*#__PURE__*/e(\"strong\",{children:\"Actuation Testing\"}),\": Devices are actuated under controlled conditions, and the emitted dose is collected and quantified.\"]})})]})]}),/*#__PURE__*/t(\"li\",{\"data-preset-tag\":\"p\",children:[/*#__PURE__*/t(\"p\",{children:[/*#__PURE__*/e(\"strong\",{children:\"In Vitro Dissolution Testing\"}),\":\"]}),/*#__PURE__*/t(\"ul\",{children:[/*#__PURE__*/e(\"li\",{\"data-preset-tag\":\"p\",children:/*#__PURE__*/e(\"p\",{children:\"Assesses the rate at which the drug dissolves in simulated lung fluid, which can predict in vivo performance.\"})}),/*#__PURE__*/e(\"li\",{\"data-preset-tag\":\"p\",children:/*#__PURE__*/t(\"p\",{children:[/*#__PURE__*/e(\"strong\",{children:\"Simulated Lung Fluid\"}),\": This involves using a medium that mimics the environment in the lungs to test how quickly the drug dissolves.\"]})})]})]}),/*#__PURE__*/t(\"li\",{\"data-preset-tag\":\"p\",children:[/*#__PURE__*/t(\"p\",{children:[/*#__PURE__*/e(\"strong\",{children:\"Stability Testing\"}),\":\"]}),/*#__PURE__*/t(\"ul\",{children:[/*#__PURE__*/e(\"li\",{\"data-preset-tag\":\"p\",children:/*#__PURE__*/e(\"p\",{children:\"Evaluates the stability of the drug product under various environmental conditions to ensure it maintains its efficacy over time.\"})}),/*#__PURE__*/e(\"li\",{\"data-preset-tag\":\"p\",children:/*#__PURE__*/t(\"p\",{children:[/*#__PURE__*/e(\"strong\",{children:\"Environmental Chamber Testing\"}),\": Samples are stored under different temperature and humidity conditions, and their stability is monitored over time.\"]})})]})]}),/*#__PURE__*/t(\"li\",{\"data-preset-tag\":\"p\",children:[/*#__PURE__*/t(\"p\",{children:[/*#__PURE__*/e(\"strong\",{children:\"Bioequivalence Studies\"}),\":\"]}),/*#__PURE__*/t(\"ul\",{children:[/*#__PURE__*/e(\"li\",{\"data-preset-tag\":\"p\",children:/*#__PURE__*/e(\"p\",{children:\"Compares the inhaled drug to an existing approved product to ensure it has the same therapeutic effect.\"})}),/*#__PURE__*/e(\"li\",{\"data-preset-tag\":\"p\",children:/*#__PURE__*/t(\"p\",{children:[/*#__PURE__*/e(\"strong\",{children:\"Comparative Testing\"}),\": Involves direct comparison of pharmacokinetic parameters between the test product and the reference product.\"]})})]})]})]})]});export const richText5=/*#__PURE__*/t(a.Fragment,{children:[/*#__PURE__*/e(\"h5\",{children:/*#__PURE__*/e(\"strong\",{children:\"Why Choose ARE Labs for Pulmonary Drug Delivery Testing?\"})}),/*#__PURE__*/e(\"p\",{children:\"At ARE Labs, we offer comprehensive testing services for pulmonary drug delivery systems. Here\u2019s why we should be your go-to partner:\"}),/*#__PURE__*/t(\"ul\",{children:[/*#__PURE__*/e(\"li\",{\"data-preset-tag\":\"p\",children:/*#__PURE__*/t(\"p\",{children:[/*#__PURE__*/e(\"strong\",{children:\"State-of-the-Art Facilities\"}),\": Our lab is equipped with cutting-edge technology and instruments to conduct a wide range of pulmonary drug delivery tests.\"]})}),/*#__PURE__*/e(\"li\",{\"data-preset-tag\":\"p\",children:/*#__PURE__*/t(\"p\",{children:[/*#__PURE__*/e(\"strong\",{children:\"Expert Team\"}),\": Our team of scientists and technicians have extensive experience and expertise in pulmonary drug delivery testing and regulatory requirements.\"]})}),/*#__PURE__*/e(\"li\",{\"data-preset-tag\":\"p\",children:/*#__PURE__*/t(\"p\",{children:[/*#__PURE__*/e(\"strong\",{children:\"Regulatory Compliance\"}),\": We adhere to all relevant regulatory guidelines and standards, ensuring that your products meet the highest quality and safety standards.\"]})}),/*#__PURE__*/e(\"li\",{\"data-preset-tag\":\"p\",children:/*#__PURE__*/t(\"p\",{children:[/*#__PURE__*/e(\"strong\",{children:\"Customized Solutions\"}),\": We provide tailored testing solutions to meet the specific needs of your drug product and development stage.\"]})}),/*#__PURE__*/e(\"li\",{\"data-preset-tag\":\"p\",children:/*#__PURE__*/t(\"p\",{children:[/*#__PURE__*/e(\"strong\",{children:\"Comprehensive Services\"}),\": From initial testing to regulatory submission support, we offer a full suite of services to help you bring your product to market efficiently and effectively.\"]})})]}),/*#__PURE__*/e(\"p\",{children:/*#__PURE__*/e(\"br\",{className:\"trailing-break\"})})]});export const richText6=/*#__PURE__*/t(a.Fragment,{children:[/*#__PURE__*/e(\"h5\",{children:/*#__PURE__*/e(\"strong\",{children:\"Conclusion\"})}),/*#__PURE__*/e(\"p\",{children:\"Pulmonary drug delivery studies are essential for ensuring that inhalation products are safe, effective, and of high quality. By adhering to stringent regulatory guidelines and employing comprehensive testing methods, manufacturers can guarantee the success of their drug products. ARE Labs is dedicated to providing top-notch pulmonary drug delivery testing services, helping you achieve your goals with precision and reliability. Contact us today to learn more about our services and how we can support your pulmonary drug delivery research and development needs.\"}),/*#__PURE__*/e(\"p\",{children:\"For more information about our services and how we can assist with your testing needs, please contact us today.\"})]});export const richText7=/*#__PURE__*/t(a.Fragment,{children:[/*#__PURE__*/e(\"p\",{children:/*#__PURE__*/e(\"em\",{children:/*#__PURE__*/e(\"strong\",{children:\"Introduction\"})})}),/*#__PURE__*/e(\"p\",{children:\"Ultraviolet (UV) technology has long been recognized for its effectiveness in microbial decontamination. Recently, Far UV has emerged as a promising alternative, offering unique advantages. This blog explores the differences between UV and Far UV for microbial decontamination, focusing on their effectiveness in air and surface disinfection.\"})]});export const richText8=/*#__PURE__*/e(a.Fragment,{children:/*#__PURE__*/e(\"p\",{children:/*#__PURE__*/t(\"em\",{children:[/*#__PURE__*/e(\"strong\",{children:\"Figure 1:\"}),\"\\xa0 UV Spectrum and Wavelength.\"]})})});export const richText9=/*#__PURE__*/t(a.Fragment,{children:[/*#__PURE__*/e(\"p\",{children:/*#__PURE__*/e(\"em\",{children:/*#__PURE__*/e(\"strong\",{children:\"Understanding UV and Far UV\"})})}),/*#__PURE__*/e(\"p\",{children:\"UV radiation spans a spectrum of wavelengths, typically divided into three categories: UV-A, UV-B, and UV-C. Each has unique properties:\"}),/*#__PURE__*/t(\"p\",{children:[/*#__PURE__*/e(\"br\",{}),/*#__PURE__*/e(\"strong\",{children:\"UV-A:\"}),\" The longest wavelength ranges from 320 to 400 nanometers (nm). It is least effective at killing microbes but is widely present in sunlight and used in tanning beds.\",/*#__PURE__*/e(\"br\",{}),/*#__PURE__*/e(\"strong\",{children:\"UV-B\"}),\": Ranging from 280 to 320 nm, UV-B is more energetic and can cause skin burns. It's also useful for vitamin D synthesis in humans.\",/*#__PURE__*/e(\"br\",{}),/*#__PURE__*/e(\"strong\",{children:\"UV-C:\"}),\" The most germicidal of the UV wavelengths, UV-C ranges from 100 to 280 nm. It's commonly used in sterilization due to its effectiveness in inactivating pathogens. Most UV-C devices fall within the 260-280nm range.\"]}),/*#__PURE__*/e(\"p\",{children:\"Far UV, typically at a wavelength around 222 nm, falls within the UV-C range but has distinct characteristics. Unlike conventional UV-C radiation, which can cause skin and eye irritation, Far UV is safer for human exposure due to its shallow penetration. This makes it suitable for continuous use in occupied spaces.\"}),/*#__PURE__*/e(\"p\",{children:/*#__PURE__*/e(\"em\",{children:/*#__PURE__*/e(\"strong\",{children:\"Microbial Decontamination in Air\"})})}),/*#__PURE__*/e(\"p\",{children:\"Airborne pathogens pose significant health risks, particularly in shared spaces. UV and Far UV are both effective in air disinfection. UV systems use lamps or LEDs to irradiate the air passing through a ventilation system or within a room. These systems are effective but pose risks to human health if misused. Far UV, on the other hand, offers continuous irradiation without risking human exposure. Studies show that Far UV is effective against many airborne microbes, including viruses and bacteria, making it a promising solution for air decontamination.\"})]});export const richText10=/*#__PURE__*/e(a.Fragment,{children:/*#__PURE__*/t(\"p\",{children:[/*#__PURE__*/e(\"strong\",{children:\"Figure 2:\"}),\"\\xa0 \",/*#__PURE__*/e(\"em\",{children:\"UVC Relative Dosing Requirements for deactivation of microbes (260 nm).\"})]})});export const richText11=/*#__PURE__*/t(a.Fragment,{children:[/*#__PURE__*/e(\"p\",{children:/*#__PURE__*/e(\"em\",{children:/*#__PURE__*/e(\"strong\",{children:\"Microbial Decontamination on Surfaces\"})})}),/*#__PURE__*/e(\"p\",{children:\"Surfaces can harbor pathogens, contributing to the spread of infections. UV light has been widely used for surface disinfection, particularly in healthcare settings. It's effective but can be harmful if misused. Far UV offers similar efficacy but with improved safety, making it suitable for continuous use in high-touch areas like desks, door handles, and medical equipment. Both methods are effective for surface disinfection, but Far UV allows for safer, on-demand disinfection in occupied spaces.\"})]});export const richText12=/*#__PURE__*/e(a.Fragment,{children:/*#__PURE__*/t(\"p\",{children:[/*#__PURE__*/e(\"strong\",{children:\"Figure 3:\"}),\"\\xa0 \",/*#__PURE__*/e(\"em\",{children:\"Far UV Relative absorbance for various pathogens showing that 222nm has a higher absorbance that that of 260nm.\"})]})});export const richText13=/*#__PURE__*/t(a.Fragment,{children:[/*#__PURE__*/e(\"p\",{children:/*#__PURE__*/e(\"em\",{children:/*#__PURE__*/e(\"strong\",{children:\"Applications and Industry Use\"})})}),/*#__PURE__*/e(\"p\",{children:\"UV and Far UV technologies have diverse applications across the healthcare, hospitality, and transportation industries. UV is used for terminal cleaning in healthcare, while Far UV can disinfect high-touch areas during regular operations. In hospitality, UV is used for room cleaning, while Far UV can maintain cleanliness in common areas. The transportation industry also benefits from these technologies, as they can disinfect cabins, waiting areas, and equipment. Both technologies offer unique advantages, and their use depends on the specific needs of each industry.\"}),/*#__PURE__*/e(\"p\",{children:/*#__PURE__*/e(\"em\",{children:/*#__PURE__*/e(\"strong\",{children:\"\\xa0ARE Labs' Role in Decontamination Testing\"})})}),/*#__PURE__*/e(\"p\",{children:\"ARE Labs provides comprehensive testing services to ensure the effectiveness of UV and Far UV technologies. Our lab specializes in aerosol and surface testing, offering advanced analyses like HPLC. We help clients validate their decontamination strategies, providing data-driven insights for effective disinfection. Businesses can leverage our expertise to ensure their decontamination solutions meet industry standards.\"}),/*#__PURE__*/e(\"p\",{children:/*#__PURE__*/e(\"em\",{children:/*#__PURE__*/e(\"strong\",{children:\"Conclusion\"})})}),/*#__PURE__*/e(\"p\",{children:\"UV and Far UV technologies play crucial roles in microbial decontamination. While UV has a proven track record, Far UV offers enhanced safety for continuous use. Both methods are effective for air and surface disinfection, with applications across various industries. ARE Labs can assist businesses in validating their decontamination solutions, ensuring effective and safe microbial control.\"})]});export const richText14=/*#__PURE__*/t(a.Fragment,{children:[/*#__PURE__*/e(\"p\",{children:/*#__PURE__*/e(\"strong\",{children:\"Introduction\"})}),/*#__PURE__*/e(\"p\",{children:\"The ongoing global concern over airborne diseases has highlighted the critical need for effective air quality management in public and private spaces. Infectious aerosols are a primary vector for the transmission of respiratory diseases. The COVID-19 pandemic and yearly flu outbreaks underscore the importance of managing these aerosols in indoor environments to prevent widespread health crises.\"}),/*#__PURE__*/e(\"p\",{children:'In response to this need, the American Society of Heating, Refrigerating, and Air-Conditioning Engineers (ASHRAE) has developed Standard 241, \"Control of Infectious Aerosols.\" This standard is essential for architects, HVAC engineers, and public health officials aiming to enhance indoor air quality and reduce disease transmission. Many labs cannot perform the biological or chemical aspects of this standard. At ARE Labs, we provide all the testing for ASHRAE Standard 241 under one roof.'}),/*#__PURE__*/e(\"p\",{children:/*#__PURE__*/e(\"strong\",{children:\"Overview of ASHRAE 241\"})}),/*#__PURE__*/e(\"p\",{children:\"ASHRAE Standard 241 provides guidelines and strategies for mitigating the risk of infectious aerosol transmission in buildings. The standard covers various aspects of building design, operation, and maintenance that contribute to indoor air quality and health safety.\"}),/*#__PURE__*/e(\"p\",{children:/*#__PURE__*/e(\"strong\",{children:\"Critical Components of the Testing\"})}),/*#__PURE__*/e(\"p\",{children:\"Testing Environment: All ASHRAE 241 testing takes place in a state-of-the-art 30m3 sealed testing chamber under strict environmental conditions outlined in the standard.\"}),/*#__PURE__*/e(\"p\",{children:\"Testing Species: All ASHRAE 241 biological testing is done with the unenveloped positive sense single-stranded RNA virus MS2 bacteriophage. Formaldehyde, ozone, and particulates are monitored for the safety portion of the standard.\"}),/*#__PURE__*/e(\"p\",{children:/*#__PURE__*/e(\"strong\",{children:\"Testing Method Overview\"})}),/*#__PURE__*/e(\"p\",{children:\"ASHRAE Standard 241 required testing:\"}),/*#__PURE__*/t(\"ul\",{children:[/*#__PURE__*/e(\"li\",{\"data-preset-tag\":\"p\",children:/*#__PURE__*/e(\"p\",{children:\"MS2 bacteriophage bioaerosol reduction testing\"})}),/*#__PURE__*/e(\"li\",{\"data-preset-tag\":\"p\",children:/*#__PURE__*/e(\"p\",{children:\"Formaldehyde byproduct formation testing\"})}),/*#__PURE__*/e(\"li\",{\"data-preset-tag\":\"p\",children:/*#__PURE__*/e(\"p\",{children:\"Ozone byproduct testing according to UL867 guidelines\"})}),/*#__PURE__*/e(\"li\",{\"data-preset-tag\":\"p\",children:/*#__PURE__*/e(\"p\",{children:\"Particulate testing according to ISO18644-14\"})}),/*#__PURE__*/e(\"li\",{\"data-preset-tag\":\"p\",children:/*#__PURE__*/e(\"p\",{children:\"Noise production testing\"})})]})]});export const richText15=/*#__PURE__*/e(a.Fragment,{children:/*#__PURE__*/e(\"p\",{children:/*#__PURE__*/t(\"em\",{children:[/*#__PURE__*/e(\"strong\",{children:\"Figure 1\"}),\": Example plot ASHRAE Standard 241 log-reduction results using for RNA Virus MS2.\\xa0 Triplicate controls and triplicate trials tested in a 30m3 Bioaerosol Chamber.\"]})})});export const richText16=/*#__PURE__*/t(a.Fragment,{children:[/*#__PURE__*/e(\"p\",{children:/*#__PURE__*/e(\"strong\",{children:\"Calculation of Clean Air Delivery Rate\"})}),/*#__PURE__*/e(\"p\",{children:\"The Clean Air Delivery Rate (CADR) is a crucial metric in the assessment of air purifiers, particularly in the context of ASHRAE 241 bioaerosol testing. CADR quantifies the volume of filtered air delivered by an air purifier, measured in cubic feet per minute (CFM). This metric reflects the efficiency and effectiveness of an air purifier in removing specific pollutants, including bioaerosols, from indoor air.\"})]});export const richText17=/*#__PURE__*/e(a.Fragment,{children:/*#__PURE__*/e(\"p\",{children:/*#__PURE__*/t(\"em\",{children:[/*#__PURE__*/e(\"strong\",{children:\"Figure 2\"}),\": Method for Calculating the Clean Air Delivery Rate using Viral concentrations (pfu/Liter air) obtained during sampling per ASHRAE Standard 241 standard.\\xa0 The difference in the slope for the control (natural decay) and the device trial is used to calculate the devices effectiveness (CADR).\"]})})});export const richText18=/*#__PURE__*/e(a.Fragment,{children:/*#__PURE__*/e(\"p\",{children:\"The base calculation of CADR involves measuring the airflow rate and the percentage of particles removed from the air. Essentially, a higher CADR indicates a more effective air purifier. Consumers can use CADR to compare different models by looking at the ratings for various pollutants, allowing for informed decisions based on the purifier's ability to handle the specific contaminants present in their environment. By standardizing these comparisons, CADR helps ensure that air purifiers meet specific performance benchmarks, enhancing indoor air quality.\"})});export const richText19=/*#__PURE__*/e(a.Fragment,{children:/*#__PURE__*/e(\"p\",{children:/*#__PURE__*/t(\"em\",{children:[/*#__PURE__*/e(\"strong\",{children:\"Figure 3\"}),\": Table Showing the Clean Air Delivery Rate for this particular device tested in accordance with ASHRAE 241 standard.\"]})})});export const richText20=/*#__PURE__*/t(a.Fragment,{children:[/*#__PURE__*/e(\"p\",{children:/*#__PURE__*/e(\"strong\",{children:\"Implications for Public Health and Building Design\"})}),/*#__PURE__*/e(\"p\",{children:\"Implementing ASHRAE 241 can positively impact public health by reducing the incidence of airborne diseases. For architects and builders, this standard provides a framework for designing healthier buildings better equipped to control the spread of infections.\"}),/*#__PURE__*/e(\"p\",{children:/*#__PURE__*/e(\"strong\",{children:\"Future Directions\"})}),/*#__PURE__*/e(\"p\",{children:\"As research on infectious aerosols continues, ASHRAE Standard 241 will likely undergo updates and refinements. Future revisions may incorporate emerging technologies and new scientific insights, further enhancing our ability to manage airborne pathogens. ARE Labs is prepared to adapt to any changes to the standard that may occur later.\"}),/*#__PURE__*/e(\"p\",{children:/*#__PURE__*/e(\"strong\",{children:\"References and Further Reading\"})}),/*#__PURE__*/e(\"p\",{children:\"If you are interested in ASHRAE 241 testing or need more detailed information regarding the testing standard, contact ARE Labs today.\"})]});export const richText21=/*#__PURE__*/e(a.Fragment,{children:/*#__PURE__*/e(\"p\",{children:\"Welcome to Aerosol Research and Engineering Laboratories, where innovation meets precision in the world of aerosol science. With over 15 years of dedicated experience in bioaerosol efficacy testing, we are excited to announce the expansion of our services with the addition of a state-of-the-art test chamber, fully compliant with ASHRAE Standard 241. This new chamber represents a significant leap forward in our ability to conduct comprehensive and reliable aerosol testing, further enhancing our already diverse bioaerosol testing offerings. At our laboratory, commitment to excellence is more than just a promise\u2014it's a practice. Discover how our ASHRAE 241 compliant test chamber can elevate your aerosol testing to new heights.\"})});export const richText22=/*#__PURE__*/t(a.Fragment,{children:[/*#__PURE__*/e(\"p\",{children:\"Elevate your aerosol testing with our ASHRAE 241 compliant chamber at Aerosol Research and Engineering Laboratories. Benefit from unparalleled precision in bioaerosol studies. Trust in our expertise for advanced, reliable testing solutions. Contact us to enhance your projects today.\"}),/*#__PURE__*/e(\"h2\",{children:\"ARE Labs\u2019s ASHRAE 241 Testing\"}),/*#__PURE__*/e(\"p\",{children:\"At ARE Labs, we offer a comprehensive one-stop solution for all ASHRAE 241 compliance needs, eliminating the coordination with multiple labs. This approach saves time and simplifies your compliance process, allowing you to focus on your business.\"}),/*#__PURE__*/e(\"p\",{children:'Our testing protocol fully meets ASHRAE 241 standards, including Bioaerosol, Ozone, Formaldehyde, Particulate, and Sound Testing. We cover all essential health and safety requirements, ensuring your facility is fully compliant and operational.\"'})]});export const richText23=/*#__PURE__*/t(a.Fragment,{children:[/*#__PURE__*/e(\"p\",{children:\"Partner with ARE Labs for seamless, comprehensive compliance solutions\u2014where your safety and satisfaction are our highest priority.\"}),/*#__PURE__*/e(\"p\",{children:/*#__PURE__*/e(\"br\",{className:\"trailing-break\"})}),/*#__PURE__*/e(\"h5\",{children:\"Jamie Balarashti  \"}),/*#__PURE__*/e(\"h5\",{children:\"President and Founder\"})]});export const richText24=/*#__PURE__*/t(a.Fragment,{children:[/*#__PURE__*/e(\"h2\",{children:\"Overview\"}),/*#__PURE__*/e(\"p\",{children:\"This study evaluated the effectiveness of surgical, N95, and N100 respirators in filtering airborne viral particles using a highly controlled experimental setup. We employed a 1,000-liter Lexan chamber specifically designed for bioaerosol experiments, fitted with multiple sampling ports to measure airborne particulates. To generate a viral aerosol, we used a six-jet Collison nebulizer dispersing MS2 bacteriophage particles into the chamber.\"}),/*#__PURE__*/e(\"p\",{children:\"Inside this chamber, a manikin connected to a respiratory simulation system was positioned. This system comprised a polyvinyl chloride (PVC) throat with a midget impinger\u2014an air sampling device\u2014to collect the inhaled particulates. The system also included a filter along the inspiratory flow path to prevent bioaerosol entry, and a Lifecare\\xae PLV-100 mechanical piston ventilator simulated the breathing patterns of an adult at rest. The ventilator was calibrated to a tidal volume of 0.70 liters and a breathing rate of 16 breaths per minute, with an inspiration-to-expiration (I:E) ratio of 1:2.5, achieving a peak inspiratory flow rate of 60 liters/minute.\"}),/*#__PURE__*/e(\"p\",{children:\"In this study, we used Schlieren imaging to visualize airflow patterns and identify leaks in the fit of surgical masks. Schlieren imaging, a method that exploits variations in air density to visualize flow patterns and turbulence, clearly illustrated the general inadequacies in the fit of surgical masks. Despite being designed to filter out particles, these masks often had visible leaks, particularly under the chin and around the nose, as well as at several other points along the mask's perimeter. These gaps allowed air to escape without filtration, reducing the overall effectiveness of the masks. However, the imaging also confirmed that a significant portion of breath was indeed passing through the mask material, indicating some level of filtration was occurring. This demonstrates that while surgical masks do not seal perfectly, they are capable of providing partial protection by filtering out airborne particles as air passes through their fabric.\"}),/*#__PURE__*/e(\"img\",{alt:\"Schlieren Imaging Mask - ARE Labs\",className:\"framer-image\",\"data-framer-asset\":\"data:framer/asset-reference,3qHByQFRW1eVMnxTtP5VMAwGBfA.gif?preferredSize=lossless\",\"data-framer-height\":\"561\",\"data-framer-width\":\"600\",height:\"280\",src:\"https://framerusercontent.com/images/3qHByQFRW1eVMnxTtP5VMAwGBfA.gif?lossless=1\",srcSet:\"https://framerusercontent.com/images/3qHByQFRW1eVMnxTtP5VMAwGBfA.gif?scale-down-to=512&lossless=1 512w,https://framerusercontent.com/images/3qHByQFRW1eVMnxTtP5VMAwGBfA.gif?lossless=1 600w\",style:{aspectRatio:\"600 / 561\"},width:\"300\"}),/*#__PURE__*/e(\"h6\",{children:\"Figure 1: Schlieren imaging of surgical mask on manikin.  Image shows air currents during exhalation.\"}),/*#__PURE__*/e(\"h2\",{children:\"Viral Protection Results\"}),/*#__PURE__*/e(\"p\",{children:\"Our findings indicate that none of the masks provided complete protection against inhalation of infectious aerosols. Surgical masks were particularly ineffective, blocking only about 11.9% \\xb1 10.2% of viral particles and predominantly allowing air (and potential viral particles) to escape laterally, rather than through the mask material itself. The Food and Drug Administration (FDA) has already indicated that surgical masks do not offer adequate filtration of bioaerosols and are designed to be loose-fitting.\"}),/*#__PURE__*/e(\"p\",{children:\"The N95 respirators showed a somewhat better performance, with a 39.2% \\xb1 19.5% reduction in particle inhalation. They primarily directed exhaled air through the mask material, although some gaps near the nostrils were noted. However, even this level of protection is below the FDA\u2019s recommended 4-log (99.99%) reduction for air purifying devices.\"}),/*#__PURE__*/e(\"p\",{children:\"N100 masks demonstrated the highest filtration efficacy among the tested masks, with an 82% \\xb1 30.5% reduction, equivalent to a 0.74 \\xb1 0.16 log reduction in inhaled bioaerosols. Despite this, the performance still falls short of the FDA\u2019s standards.\"}),/*#__PURE__*/e(\"img\",{alt:\"Covid Mask Testing Data\",className:\"framer-image\",\"data-framer-asset\":\"data:framer/asset-reference,71fhVeLvwZ2jKOQw4EqHGb4Zl94.png?preferredSize=auto\",\"data-framer-height\":\"654\",\"data-framer-width\":\"902\",height:\"327\",src:\"https://framerusercontent.com/images/71fhVeLvwZ2jKOQw4EqHGb4Zl94.png\",srcSet:\"https://framerusercontent.com/images/71fhVeLvwZ2jKOQw4EqHGb4Zl94.png?scale-down-to=512 512w,https://framerusercontent.com/images/71fhVeLvwZ2jKOQw4EqHGb4Zl94.png 902w\",style:{aspectRatio:\"902 / 654\"},width:\"451\"}),/*#__PURE__*/e(\"h6\",{children:\"Figure 2: Reduction of inhaled virus by mask type compared to controls (no mask).\"}),/*#__PURE__*/e(\"h2\",{children:\"Summary\"}),/*#__PURE__*/e(\"p\",{children:\"In conclusion, while the material of N95 and N100 masks can theoretically filter out most viral particles, real-world factors such as fit and wearer movement significantly reduce their effectiveness. This study underscores the need for better-fitting respiratory protection, particularly in medical and public health settings, to prevent the inhalation of infectious aerosols. The results and graphical data on the net reduction of inhaled viral load for each mask type clearly illustrate the varying levels of protection offered by these respirators.\"}),/*#__PURE__*/e(\"p\",{children:\"The full paper and a one-page summary can be downloaded and viewed below:\"}),/*#__PURE__*/e(\"p\",{children:/*#__PURE__*/e(i,{href:\"https://arelabs.com/wp-content/uploads/2020/09/ARE-Labs-Facemasks-and-Respirators-as-a-Non-Pharmaceutical-Protective-Measure-in-Preventing-Viral-Infection-2020-2.pdf\",nodeId:\"JmhujK3L9\",openInNewTab:!0,smoothScroll:!1,children:/*#__PURE__*/e(\"a\",{children:\"Full Report \u2013 Web Version\"})})}),/*#__PURE__*/e(\"p\",{children:/*#__PURE__*/e(i,{href:\"https://arelabs.com/wp-content/uploads/2020/09/ARE-Labs-Facemasks-and-Respirators-as-a-Non-Pharmaceutical-Protective-Measure-in-Preventing-Viral-Infection-2020-2.gif\",nodeId:\"JmhujK3L9\",openInNewTab:!0,smoothScroll:!1,children:/*#__PURE__*/e(\"a\",{children:\"Mask Study \u2013 One Page\"})})})]});export const richText25=/*#__PURE__*/t(a.Fragment,{children:[/*#__PURE__*/t(\"p\",{children:[\"It was the 2009 \u201CFamily Smoking Prevention and Tobacco Control Act, that gave the Food and Drug Administration (\u201CFDA\u201D) more control over the \",/*#__PURE__*/e(i,{href:\"http://www.fda.gov/TobaccoProducts/Labeling/ucm388395.htm\",nodeId:\"JmhujK3L9\",openInNewTab:!0,smoothScroll:!1,children:/*#__PURE__*/e(\"a\",{children:\"U.S. tobacco products\"})}),\" and the ability to regulate and require e-cigarette testing.\\xa0 As a result, the FDA had introduced regulations deeming e-cigarettes a tobacco product. The major e-cigarette issue is centered around a \u201Cgrandfather\u201D date that will determine which products can remain on the market and which products will be strictly enforced with stringent regulatory barriers. In April 2014, upcoming \",/*#__PURE__*/e(i,{href:\"http://www.fda.gov/NewsEvents/PublicHealthFocus/ucm172906.htm\",nodeId:\"JmhujK3L9\",openInNewTab:!0,smoothScroll:!1,children:/*#__PURE__*/e(\"a\",{children:\"FDA regulations for Electronic Nicotine Delivery Systems Systems (ENDS) Testing \"})}),\"were released that will change the e-cigarette industry and impact it negatively. The FDA is requiring e-cig manufacturers to introduce the following:\"]}),/*#__PURE__*/t(\"ul\",{style:{\"--framer-font-size\":\"14px\",\"--framer-text-alignment\":\"start\",\"--framer-text-color\":\"rgb(53, 53, 53)\",\"--framer-text-transform\":\"none\"},children:[/*#__PURE__*/e(\"li\",{\"data-preset-tag\":\"p\",children:/*#__PURE__*/e(\"p\",{children:\"Warning labels on vaping devices which can include about 4 warnings\"})}),/*#__PURE__*/e(\"li\",{\"data-preset-tag\":\"p\",children:/*#__PURE__*/e(\"p\",{children:\"Prohibit sales to minors\"})}),/*#__PURE__*/e(\"li\",{\"data-preset-tag\":\"p\",children:/*#__PURE__*/e(\"p\",{children:\"Ban free samples and ban advertising unless approved by the FDA\"})}),/*#__PURE__*/e(\"li\",{\"data-preset-tag\":\"p\",children:/*#__PURE__*/e(\"p\",{children:\"Taxing e-cigarettes and vaper devices\"})}),/*#__PURE__*/e(\"li\",{\"data-preset-tag\":\"p\",children:/*#__PURE__*/e(\"p\",{children:\"Prohibit vaping even in banned traditional cigarette locations\"})}),/*#__PURE__*/e(\"li\",{\"data-preset-tag\":\"p\",children:/*#__PURE__*/e(\"p\",{children:\"Prohibit the flavoring of e-cigs\"})}),/*#__PURE__*/e(\"li\",{\"data-preset-tag\":\"p\",children:/*#__PURE__*/e(\"p\",{children:\"Require testing on flavorings & key Ingredients\"})}),/*#__PURE__*/e(\"li\",{\"data-preset-tag\":\"p\",children:/*#__PURE__*/e(\"p\",{children:\"General E-cigarette testing for product safety\"})})]}),/*#__PURE__*/t(\"p\",{children:[\"There isn\u2019t a fixed date when the FDA rules will be enforced. The FDA has given e-cigarette manufacturers two years, which brings us to 2016, to submit their applications, enabling them to sell their products under a review status. Right now, e-cigarette makers are trying hard to convince the FDA differently. \",/*#__PURE__*/e(i,{href:\"http://www.forbes.com/sites/jacobsullum/2014/05/01/will-fda-regulation-preserve-or-destroy-the-e-cigarette-industry/#c8f058d56193\",nodeId:\"JmhujK3L9\",openInNewTab:!0,smoothScroll:!1,children:/*#__PURE__*/e(\"a\",{children:\"The upcoming FDA regulations\"})}),\" would affect an estimated 18,000 to 12,000 vaping stores in the U.S. as well as over 1,000 manufacturers and vaping wholesalers.\"]}),/*#__PURE__*/e(\"p\",{children:\"Despite the statistics stating that many people have given up real tobacco cigarettes for e-cigs and that they are safer than nicotine laden, regular cigarettes, the FDA is bent on restricting vaping and e-cigarette sales. The basis for the FDA enforced regulations is that researchers are still unsure how safe e-cigarette vaping is on the human body. Because vaping is a relatively new industry, the long-term effects are unknown and it is considered that the chemicals used in flavoring e-cigs could \u2013 sometime in the future \u2013 have dangerous side effects.\"}),/*#__PURE__*/e(\"img\",{alt:\"\",className:\"framer-image\",\"data-framer-asset\":\"data:framer/asset-reference,nsXdXSoEVevnm1x17uhjmyius.png\",\"data-framer-height\":\"180\",\"data-framer-width\":\"440\",height:\"90\",src:\"https://framerusercontent.com/images/nsXdXSoEVevnm1x17uhjmyius.png\",style:{aspectRatio:\"440 / 180\"},width:\"220\"}),/*#__PURE__*/e(\"p\",{children:\"Aerosol Research and Engineering Laboratories Inc. (\u201CARE Labs\u201D) has been working on developing practical solutions for a wide range of aerosol products, like e-cigarettes. ARE Labs and their expert staff, are exceptionally experienced in the fields of aerosol science, aerosol fluid dynamics, and aerobiology overall. To assist in the argument of keeping e-cigarettes and their devices on store shelves, ARE Labs can offer their expert testing and customized studies in developing and testing all e-cigarette and aerosol related products.\"}),/*#__PURE__*/e(\"p\",{children:\"ARE Labs can help with specific tests to meet the new pending FDA guidelines for e-cigarette testing:\"}),/*#__PURE__*/e(\"h2\",{children:\"E-cigarette Testing:\"}),/*#__PURE__*/t(\"ul\",{style:{\"--framer-font-size\":\"14px\",\"--framer-text-alignment\":\"start\",\"--framer-text-color\":\"rgb(53, 53, 53)\",\"--framer-text-transform\":\"none\"},children:[/*#__PURE__*/e(\"li\",{\"data-preset-tag\":\"p\",children:/*#__PURE__*/e(\"p\",{children:\"Respirable Dose Delivery of Nicotine\"})}),/*#__PURE__*/e(\"li\",{\"data-preset-tag\":\"p\",children:/*#__PURE__*/e(\"p\",{children:\"Aerosol Particle Size of other flavoring components\"})}),/*#__PURE__*/e(\"li\",{\"data-preset-tag\":\"p\",children:/*#__PURE__*/e(\"p\",{children:\"In-vitro methods to determine bioavailability of delivered nicotine\"})}),/*#__PURE__*/t(\"li\",{\"data-preset-tag\":\"p\",children:[/*#__PURE__*/e(\"p\",{children:\"Inhalation Toxicity Studies on new Flavorings & Ingredients\"}),/*#__PURE__*/t(\"ul\",{children:[/*#__PURE__*/e(\"li\",{\"data-preset-tag\":\"p\",children:/*#__PURE__*/e(\"p\",{children:\"28-Day subacute Inhalation Toxicity Studies (OECD 412)\"})}),/*#__PURE__*/e(\"li\",{\"data-preset-tag\":\"p\",children:/*#__PURE__*/e(\"p\",{children:\"90-Day subchronic Inhalation Toxicity Studies (OECD 413, 40 CFR 799.9346)\"})})]})]})]}),/*#__PURE__*/e(\"img\",{alt:\"\",className:\"framer-image\",\"data-framer-asset\":\"data:framer/asset-reference,ir1qZiqhiVayhUTgfFqDQ3YyeT4.jpg\",\"data-framer-height\":\"250\",\"data-framer-width\":\"250\",height:\"125\",src:\"https://framerusercontent.com/images/ir1qZiqhiVayhUTgfFqDQ3YyeT4.jpg\",style:{aspectRatio:\"250 / 250\"},width:\"125\"}),/*#__PURE__*/t(\"p\",{children:[\"The FDA\u2019s \u201Cdeeming\u201D rules could be implemented sometime in 2016, requiring \",/*#__PURE__*/e(i,{href:\"http://www.marketwatch.com/story/the-fda-may-soon-be-able-to-vaporize-e-cigarette-products-2015-11-13\",nodeId:\"JmhujK3L9\",openInNewTab:!0,smoothScroll:!1,children:/*#__PURE__*/e(\"a\",{children:\"e-cigarette manufacturers\"})}),\" to submit to a very expensive Pre-Market Tobacco Application process, which could cost each manufacturer between $2-10 million. With these regulatory rules, 99% of the e-cigarette market could face near decimation and have to close down. However, House Bill 2058 amends the FDA\u2019s authority over different tobacco products, which includes e-cigs.\"]}),/*#__PURE__*/e(\"p\",{children:\"The FDA Deeming Authority Clarification Act of 2015 (\u201CHR 2058\u201D), was created by Representative Tom Cole of Oklahoma. HR 2058 would help the U.S. vapor industry from being destroyed because it would amend the FDA\u2019s grandfathering date and allow most vapor products currently on the market to remain on the market without being subject to a pre-market FDA approval application process.\"}),/*#__PURE__*/e(\"p\",{children:\"ARE Labs is not a stranger to the FDA and the EPA. We are a key provider for inhalation toxicology studies for pharmaceutical, biotechnology, chemical and consumer clients. ARE Labs would be glad to help our clients meet the new and demanding requirements for e-cigarette testing by manufactures.\"})]});export const richText26=/*#__PURE__*/t(a.Fragment,{children:[/*#__PURE__*/e(\"p\",{children:\"Aerosols are found everywhere. Contrary to popular belief, they are not just in your hairspray bottles, or your liquid containers. In fact, science defines an aerosol as a cluster of liquid atoms or solid particles that are suspended in the air. Aerosols are either synthetically made, or naturally found in our environment. When these particles are found in our environment, they are presented in the form of steam and fog. When these are produced synthetically, \\xa0aerosol particles or clusters present as dust, particulate air pollutants, and smoke. The size of aerosols are significant because of their implications on human, plant, and animal health. It can also be significant for other environmental concerns. Diseases can be spread by aerosol droplets suspended in the air like the flu. Also, very large particles cannot be cleared by our respiratory system, and thus can lead to asthma and other respiratory illnesses. Aerosols can be found in spray cans, in pesticides, in medical treatments, combustion technology, factories, and in many other areas of our life.\"}),/*#__PURE__*/e(\"p\",{children:\"The purpose of \\xa0aerosol particle size testing is an important issue for scientific testing because this is an issue that reaches to aspects of canned aerosol sprays and how they affect human consumption, technological uses of aerosols in industries, the effects of particle sizes on human respiration and other aspects of the environment, and in understanding the chemical stability of particles of various types of aerosols for safety precautions.\"}),/*#__PURE__*/e(\"p\",{children:\"In other science laboratories, it is important to understand the size of the particles because very tiny nano sized particles have been known to be able to penetrate the air blood barriers of the lungs. This means that nano particles of various chemical compounds can also reach the brain, heart, bladder, kidneys, and liver via respiration. This has some very significant consequences when working with aerosol technologies. This also makes it even more important to ensure that aerosol particle size testing is done. Aerosol particle testing can help scientists to understand what size of particle human beings can take in without needing respiratory safety gear, or when it is absolutely imperative to have it.\"}),/*#__PURE__*/e(\"img\",{alt:\"\",className:\"framer-image\",\"data-framer-asset\":\"data:framer/asset-reference,ic4Pqa0oKwjmv2Vm3PVsO45as.jpg\",\"data-framer-height\":\"280\",\"data-framer-width\":\"199\",height:\"140\",src:\"https://framerusercontent.com/images/ic4Pqa0oKwjmv2Vm3PVsO45as.jpg\",style:{aspectRatio:\"199 / 280\"},width:\"99\"}),/*#__PURE__*/e(\"p\",{children:\"Currently scientific experiments are testing the stability of the particles, in what circumstances they become smaller and smaller, and under what conditions. If occupational settings are settings where there is aerosol instability, leading to deagglomeration of particles, then there are likely to be certain occupational hazards.\"}),/*#__PURE__*/e(\"p\",{children:\"In terms of innovation of industries, aerosol particle size measurement can help to progress industries such as the food industry, warehousing, forestry, mining, agriculture, pharmaceutical, nutrition, solar and other energies, automobile industries, and other material processing industries.\"}),/*#__PURE__*/e(\"p\",{children:\"In nano particle labs, for instance, scientists work with very small aerosol particles to help innovate and develop biomedical equipment and techniques, electronics, optic electrics, different types of ceramics, paints, sealants, and pharmaceutical applications. End users of these products also benefit from particle size measurement because the end products will likely have varied properties such as glossy surfaces, larger surface areas, and different packaging densities, based on the particle size measurement and production in innovation laboratories.\"}),/*#__PURE__*/e(\"p\",{children:\"If aerosol particle size data is insufficient, unmeasured, poorly measured or inaccurate, the end properties of mixtures, chemical combinations, and end products will exhibit very different properties, hence affecting the final product and the suppliers/consumers that the product is being made for. In addition to the above mentioned factors, differences can also be seen in the rheology, polishing capability, film gloss, and surface area of the final end product. Without proper aerosol particle measurement, these factors cannot be controlled for or predicted, in order to make a carefully designed and targeted end product.\"}),/*#__PURE__*/e(\"p\",{children:\"In order to produce the best results, aerosol particle size testing and measurement are recommended. There are many different ways and many different machines that can help with this process. Sample handling precautions and rules need to be strict in order to produce the best measurements. Reliable and consistent results of these analyses are critical to achieve stable compounds and a high quality end product. Most innovators and scientists recognize this need and fortunately rapid to use, modern and technological processes are now coming into place to meet these specific needs. This allows for aerosol particle sizing and characterization to be measured at faster speeds and with more accuracy.\"}),/*#__PURE__*/e(\"p\",{children:/*#__PURE__*/e(\"br\",{className:\"trailing-break\"})}),/*#__PURE__*/e(\"h2\",{children:\"Need to Know More on the Purpose of Aerosol Particle Testing?, ARE Labs has the answers. Give us a call Today!!!\"}),/*#__PURE__*/e(\"h2\",{children:\"913-850-6630\"})]});export const richText27=/*#__PURE__*/t(a.Fragment,{children:[/*#__PURE__*/e(\"p\",{children:\"Researchers avail many documents that link particle size with drug performance in terms of the rates of absorption, dissolution, and content uniformity. One of the benefits of pharmaceutical particle size testing is to help pharmaceutical companies in their effort to manufacture and formulate many of their dosage forms appropriately. There are various approaches and technique such as Laser Diffraction Measurement available to perform the testing depending on the product formulation. An intensive study of the particle size, from drug development stage to manufacturing, can enable them to develop safe, efficient and stable products. This is because they can control contaminating particles \\xa0and improve drug performance as discussed below.\"}),/*#__PURE__*/e(\"p\",{children:/*#__PURE__*/e(\"strong\",{children:\"Reducing contamination\"})}),/*#__PURE__*/e(\"p\",{children:\"Testing the size of drug particles will serve as an indicator of contamination. Following this, a company can install measures to control the limits of the contaminating particles, which is critical especially for parenteral or injectable solutions. Here are some of the potential results of excessive contamination in drug solutions.\"}),/*#__PURE__*/t(\"ul\",{style:{\"--framer-font-size\":\"14px\",\"--framer-text-alignment\":\"start\",\"--framer-text-color\":\"rgb(53, 53, 53)\",\"--framer-text-transform\":\"none\"},children:[/*#__PURE__*/e(\"li\",{\"data-preset-tag\":\"p\",children:/*#__PURE__*/e(\"p\",{children:\"Drugs with particle contamination can have a direct adverse reaction in a user\u2019s body. For instance, particles of a certain size can physically block blood flow such as in the lungs, or the particle may be distributed in the body via the blood and can lead to toxicity to certain organs or tissues.\"})}),/*#__PURE__*/e(\"li\",{\"data-preset-tag\":\"p\",children:/*#__PURE__*/e(\"p\",{children:\"Particle contamination can also contribute to adverse reaction indirectly. A drug user\u2019s immune system can identify certain particles as foreign material, making it impose secondary effects.\"})})]}),/*#__PURE__*/e(\"p\",{children:\"Therefore, it is vital for pharmaceutical companies to use various techniques available for characterization of limits in order to guarantee high-quality product and to protect their patients.\"}),/*#__PURE__*/e(\"img\",{alt:\"\",className:\"framer-image\",\"data-framer-asset\":\"data:framer/asset-reference,CYbmF5jsdjlSdTCNDr8sDrRGlE.jpg\",\"data-framer-height\":\"300\",\"data-framer-width\":\"400\",height:\"150\",src:\"https://framerusercontent.com/images/CYbmF5jsdjlSdTCNDr8sDrRGlE.jpg\",style:{aspectRatio:\"400 / 300\"},width:\"200\"}),/*#__PURE__*/e(\"p\",{children:/*#__PURE__*/e(\"strong\",{children:\"Improving drug performance\"})}),/*#__PURE__*/e(\"p\",{children:\"The particle size of the material a company uses to make its pharmaceutical excipients and drug substances have an impact on both the physical and chemical behavior of the final product. As a result, the size is significant for the behavior of granulates, emulsions, powders, creams, and liquids, among others concerning:\"}),/*#__PURE__*/t(\"ul\",{style:{\"--framer-font-size\":\"14px\",\"--framer-text-alignment\":\"start\",\"--framer-text-color\":\"rgb(53, 53, 53)\",\"--framer-text-transform\":\"none\"},children:[/*#__PURE__*/e(\"li\",{\"data-preset-tag\":\"p\",children:/*#__PURE__*/e(\"p\",{children:\"Solubility\"})}),/*#__PURE__*/e(\"li\",{\"data-preset-tag\":\"p\",children:/*#__PURE__*/e(\"p\",{children:\"Bioavailability\"})}),/*#__PURE__*/e(\"li\",{\"data-preset-tag\":\"p\",children:/*#__PURE__*/e(\"p\",{children:\"Filterability\"})}),/*#__PURE__*/e(\"li\",{\"data-preset-tag\":\"p\",children:/*#__PURE__*/e(\"p\",{children:\"Flowability\"})}),/*#__PURE__*/e(\"li\",{\"data-preset-tag\":\"p\",children:/*#__PURE__*/e(\"p\",{children:\"Adhesive strength\"})}),/*#__PURE__*/e(\"li\",{\"data-preset-tag\":\"p\",children:/*#__PURE__*/e(\"p\",{children:\"Thermal conductivity\"})}),/*#__PURE__*/e(\"li\",{\"data-preset-tag\":\"p\",children:/*#__PURE__*/e(\"p\",{children:\"Drying properties\"})})]}),/*#__PURE__*/e(\"p\",{children:\"Particle size testing is particularly essential when a company is using new drug delivery formats such as nanoparticles and liposomes. It is particularly a requirement during stability testing before a company releases the \\xa0drug to the market. This particle testing is an important activity for every pharmaceutical company to consider in achieving a consistent product.\"}),/*#__PURE__*/e(\"img\",{alt:\"\",className:\"framer-image\",\"data-framer-asset\":\"data:framer/asset-reference,agvMRK1kgojhWTrnuY0iH4do4I.jpg\",\"data-framer-height\":\"126\",\"data-framer-width\":\"150\",height:\"63\",src:\"https://framerusercontent.com/images/agvMRK1kgojhWTrnuY0iH4do4I.jpg\",style:{aspectRatio:\"150 / 126\"},width:\"75\"}),/*#__PURE__*/e(\"p\",{children:\"Bioavailability of suspension or solid delivery systems is related to particle size in that the particle size controls the solubility or dissolution characteristics. Drug dissolution is faster for finer particle size and vice versa. The distribution of this particle size is also a significant factor as a narrow distribution result to more uniform dissolution. It may take some time for formulations with a relatively large particle to dissolve completely.\"}),/*#__PURE__*/e(\"p\",{children:\"Stability is a critical issue when it comes to suspensions since there is a greater likelihood of non-uniform delivery if the active ingredients settle. Studies have strongly related the settling velocity of these particles in suspension to the size of the particle as well as the physical characteristic of the fluid. Thus, particle size testing can help a company to achieve an appropriate settling velocity, which it can easily attain with finer particles.\"}),/*#__PURE__*/e(\"img\",{alt:\"\",className:\"framer-image\",\"data-framer-asset\":\"data:framer/asset-reference,6X9ccVQoK8qsYETRCUotCXKg.jpg\",\"data-framer-height\":\"203\",\"data-framer-width\":\"153\",height:\"101\",src:\"https://framerusercontent.com/images/6X9ccVQoK8qsYETRCUotCXKg.jpg\",style:{aspectRatio:\"153 / 203\"},width:\"76\"}),/*#__PURE__*/e(\"p\",{children:\"Furthermore, particle size may influence the behavior of a formulation during processing, which will ultimately affect its content uniformity. For instance, during the direct compression tableting process, the size of the particle can influence the rate at which powder flows via the press, compressibility and the segregation behavior of the formulation. Intensive Study of particle size can thus help a company to improve the consistency of its tablet\u2019s composition and weight, and the mechanical properties of the final product. It can also improve how the press works.\"}),/*#__PURE__*/e(\"p\",{children:\"In conclusion, researchers are using sophisticated analytical techniques to show that particle size, as well as shape, can be influential. Since health policies regarding safety assessment of drugs require all information about potential contaminants of infusions and injections, pharmaceutical companies need to conduct particle size testing. Many companies within the industry of dry powder inhalers, tablets, creams and suspensions are recently assigning particle size specifications for their pharmaceutical products.\"}),/*#__PURE__*/e(\"p\",{children:\"\\xa0\"}),/*#__PURE__*/e(\"h2\",{children:\"Need More Information on The Benefits of Pharmaceutical Particle Size Testing? ARE Labs can help, give us a call!\"}),/*#__PURE__*/e(\"h2\",{children:\"913-850-6630\"})]});export const richText28=/*#__PURE__*/t(a.Fragment,{children:[/*#__PURE__*/e(\"p\",{children:\"Antimicrobial Testing Laboratory is a microbiology laboratory and it offers a wide range of testing capabilities, which are performed by experienced and specialized microbiologists. This laboratory performs various product efficacy tests to support companies, which make antimicrobial products. Clients gets much needed support from this laboratory, which include designing simple proof-of-concept screening tests to conducting complex, large scale GLP- compliant studies for FDA and EPA.\"}),/*#__PURE__*/e(\"p\",{children:\"Many methods can be used for testing antimicrobial objects, textiles and surfaces. These methods differ in terms of compatibility with the level of standardization, sensitivity to antimicrobial activity and test material. In order to get the accurate result, you must use the best test method. Services offered by an antimicrobial testing laboratory include:\"}),/*#__PURE__*/t(\"ul\",{children:[/*#__PURE__*/e(\"li\",{\"data-preset-tag\":\"p\",children:/*#__PURE__*/e(\"p\",{children:\"Disinfectants/sanitizers\"})}),/*#__PURE__*/e(\"li\",{\"data-preset-tag\":\"p\",children:/*#__PURE__*/e(\"p\",{children:\"Medical devices\"})}),/*#__PURE__*/e(\"li\",{\"data-preset-tag\":\"p\",children:/*#__PURE__*/e(\"p\",{children:\"Antimicrobial surfaces\"})}),/*#__PURE__*/e(\"li\",{\"data-preset-tag\":\"p\",children:/*#__PURE__*/e(\"p\",{children:\"Virucidal disinfectants\"})}),/*#__PURE__*/e(\"li\",{\"data-preset-tag\":\"p\",children:/*#__PURE__*/e(\"p\",{children:\"Preservatives\"})}),/*#__PURE__*/e(\"li\",{\"data-preset-tag\":\"p\",children:/*#__PURE__*/e(\"p\",{children:\"Antimicrobial devices\"})})]}),/*#__PURE__*/e(\"p\",{children:/*#__PURE__*/e(\"strong\",{children:\"Disinfectants/Sanitizers\"})}),/*#__PURE__*/e(\"p\",{children:\"The testing laboratory can provide a complete EPA, ASTM, AOAC and other test methods to support companies, which manufacture germicidal chemicals. The lab is GLP compliant and EPA inspected.\"}),/*#__PURE__*/e(\"p\",{children:/*#__PURE__*/e(\"strong\",{children:\"Medical Devices\"})}),/*#__PURE__*/e(\"p\",{children:\"Proper antimicrobial testing is essential for preventing infections. Medical devices can be used antimicrobial agents, so the testing laboratory can perform GLP antimicrobial efficacy studies for supporting companies.\"}),/*#__PURE__*/e(\"p\",{children:/*#__PURE__*/e(\"strong\",{children:\"Virucidal Disinfectants\"})}),/*#__PURE__*/e(\"p\",{children:\"The number of laboratories that test products against viruses is very minimal in the US. However, antimicrobial testing laboratories can maintain a large collection of pathogenic viruses for efficacy testing.\"}),/*#__PURE__*/e(\"p\",{children:/*#__PURE__*/e(\"strong\",{children:\"Preservatives\"})}),/*#__PURE__*/e(\"p\",{children:\"Preservatives can also be tested in this testing laboratory. Generally, preservatives ensure the microbiological stability of cosmetics, cleaners and reagents. Testing labs can also undertake various preservative test methods.\"}),/*#__PURE__*/e(\"p\",{children:/*#__PURE__*/e(\"strong\",{children:\"Antimicrobial Devices\"})}),/*#__PURE__*/e(\"p\",{children:\"The testing lab can also perform antimicrobial device testing, which range from room UV disinfection devices to foggers.\"}),/*#__PURE__*/e(\"p\",{children:/*#__PURE__*/e(\"strong\",{children:\"Disinfectants\"})}),/*#__PURE__*/e(\"p\",{children:\"Sanitizers and disinfectants are chemicals, which are used for inactivating microorganisms on inanimate surfaces. Disinfectants and antibiotics are different though both of them are used for killing germs. Both of them are also considered as antimicrobial. Disinfectants can destroy many components of microorganisms, but they are not safe to inject or ingest. On the other hand, antibiotics disrupt one or more parts of microorganisms and they are relatively minimal toxicity to body.\"}),/*#__PURE__*/e(\"p\",{children:\"Most disinfectants contain different ingredients, which include detergents, fragrances and water. These shelf-stable, complete solutions are called formulations. Most disinfectants are excellent cleaners as well. The active ingredient is the chemical that kills microorganisms. These disinfectants are used for killing microorganisms in your body. In such case, these are called antiseptics. Active ingredients, that are used on hands, are called hand sanitizers. Some potent active ingredients are used in high concentration to sterilize medical equipment like surgical endoscopes, without heat. The formulation, which sterilizes medical equipment is known as cold sterilants.\"}),/*#__PURE__*/e(\"p\",{children:\"Inanimate surface sanitizers and disinfectants are regulated by the US Environmental Protection Agency (EPA) as pesticides. EPA considers fungi, parasites, viruses and bacteria as pests. The finished products must be tested for antimicrobial efficacy to determine how and where the product is intended to be used. Shelf-life, durability and preservation challenges are some considerations while selecting an antimicrobial testing laboratory for a specific industry or product. Therefore, you must be very careful while selecting a laboratory for antimicrobial testing.\"}),/*#__PURE__*/e(\"h2\",{children:\"ARE LABS INC. is your solution when searching for a local\\xa0Antimicrobial Testing Laboratory. \\xa0\"}),/*#__PURE__*/e(\"h2\",{children:\"Call Us: 913-850-6630\"})]});export const richText29=/*#__PURE__*/t(a.Fragment,{children:[/*#__PURE__*/e(\"p\",{children:\"Biological aerosol is a suspension of airborne particles that have living organisms or were produced from live organisms. The movement of biological aerosols is impacted mainly by air density and air current. Certain atmospheric conditions favor the replication of the biological aerosols, for instance when there is a high humidity level, the rate of the spores and yeast does increase. The biological aerosols can be collected in a number of ways such as:\"}),/*#__PURE__*/t(\"ul\",{children:[/*#__PURE__*/e(\"li\",{\"data-preset-tag\":\"p\",children:/*#__PURE__*/e(\"p\",{children:\"Collection plates\"})}),/*#__PURE__*/e(\"li\",{\"data-preset-tag\":\"p\",children:/*#__PURE__*/e(\"p\",{children:\"Electrostatic collectors\"})}),/*#__PURE__*/e(\"li\",{\"data-preset-tag\":\"p\",children:/*#__PURE__*/e(\"p\",{children:\"Filter Sampling\"})}),/*#__PURE__*/e(\"li\",{\"data-preset-tag\":\"p\",children:/*#__PURE__*/e(\"p\",{children:\"Viable Cascade impactors\"})}),/*#__PURE__*/e(\"li\",{\"data-preset-tag\":\"p\",children:/*#__PURE__*/e(\"p\",{children:\"Impingers\\xa0\"})})]}),/*#__PURE__*/e(\"p\",{children:/*#__PURE__*/e(\"strong\",{children:\"Disinfectant testing\"})}),/*#__PURE__*/e(\"p\",{children:\"If a person wants to register a disinfectant product, it must be taken to a biological aerosol laboratory for testing. The disinfectant will be taken through some screening which is cost effective and it involves:\"}),/*#__PURE__*/t(\"ul\",{children:[/*#__PURE__*/e(\"li\",{\"data-preset-tag\":\"p\",children:/*#__PURE__*/e(\"p\",{children:\"Quantitative time-kill test on a liquid film\"})}),/*#__PURE__*/e(\"li\",{\"data-preset-tag\":\"p\",children:/*#__PURE__*/e(\"p\",{children:\"Quantitative time kill test on a film of bacteria\"})}),/*#__PURE__*/e(\"li\",{\"data-preset-tag\":\"p\",children:/*#__PURE__*/e(\"p\",{children:\"Minimum inhibitory concentration test\"})}),/*#__PURE__*/e(\"li\",{\"data-preset-tag\":\"p\",children:/*#__PURE__*/e(\"p\",{children:\"Minimum bactericidal concentration\"})}),/*#__PURE__*/e(\"li\",{\"data-preset-tag\":\"p\",children:/*#__PURE__*/e(\"p\",{children:\"Disinfectant neutralization testing\"})}),/*#__PURE__*/e(\"li\",{\"data-preset-tag\":\"p\",children:/*#__PURE__*/e(\"p\",{children:\"\u201CReal Life\u201D disinfectant efficiency test\"})})]})]});export const richText30=/*#__PURE__*/t(a.Fragment,{children:[/*#__PURE__*/e(\"p\",{children:/*#__PURE__*/e(\"strong\",{children:\"Virus testing\"})}),/*#__PURE__*/e(\"p\",{children:\"A number of viruses are tested in the laboratories. Virus testing is quite unique from other test methods because there should be presence of viruses before and after the product has been treated and is signaled to the scientist by infection and damage of the host cells, rather than the growth of the virus. A microscope is the one that is used to look for count zones where the host cells have been damaged. Time is actually required to give the cells to grow.\"}),/*#__PURE__*/e(\"p\",{children:/*#__PURE__*/e(\"br\",{className:\"trailing-break\"})}),/*#__PURE__*/e(\"p\",{children:/*#__PURE__*/e(\"strong\",{children:\"Preservative testing\"})}),/*#__PURE__*/e(\"p\",{children:\"Preservatives should be antimicrobial, hence they fall in line of the biological aerosol testing. Problematic biological aerosols are used such as pseudomonas aeruginosa. The following tests are used in the preservative testing:\"}),/*#__PURE__*/t(\"ul\",{children:[/*#__PURE__*/e(\"li\",{\"data-preset-tag\":\"p\",children:/*#__PURE__*/e(\"p\",{children:\"USP 51\"})}),/*#__PURE__*/e(\"li\",{\"data-preset-tag\":\"p\",children:/*#__PURE__*/e(\"p\",{children:\"Custom preservative efficiency test for towelettes\"})}),/*#__PURE__*/e(\"li\",{\"data-preset-tag\":\"p\",children:/*#__PURE__*/e(\"p\",{children:\"Preservative efficiency screens\"})}),/*#__PURE__*/e(\"li\",{\"data-preset-tag\":\"p\",children:/*#__PURE__*/e(\"p\",{children:\"Hand sanitizer testing\"})})]}),/*#__PURE__*/e(\"p\",{children:\"Antimicrobial laboratory tests are regularly done on hand sanitizers. The testing of hand sanitizer is quite complicated. The hand sanitizer testing methods are two: ASTM E2315 and the minimum inhibitory concentration test. When testing the hand sanitizer, 23 species of bacteria and one species of fungus are used.\"})]});export const richText31=/*#__PURE__*/t(a.Fragment,{children:[/*#__PURE__*/e(\"p\",{children:/*#__PURE__*/e(\"strong\",{children:\"Disinfection validation\"})}),/*#__PURE__*/e(\"p\",{children:\"Drug manufacturers are supposed to validate their disinfection procedures. The biological aerosol testing service is to validate the disinfectant by ensuring the disinfectant has the basic requirements of a good disinfectant. The tests carried out to validate the disinfectant should be done in triplicate. Disinfectant validation can also be customized to ensure that their test protocoll adequately mimic their customer\u2019s surface type that needs to be disinfected.\"})]});export const richText32=/*#__PURE__*/t(a.Fragment,{children:[/*#__PURE__*/e(\"p\",{children:/*#__PURE__*/e(\"strong\",{children:\"Fungal resistance testing\"})}),/*#__PURE__*/e(\"p\",{children:\"The fungal resistant test is done on different surfaces from drywall paint to sealant. This service is quite important to the building and construction companies. In the laboratories there are chambers that are incubators for more than 40 fungi species. The following steps should be taken to ensure that the fungi resistant tests are efficient and accurate:\"}),/*#__PURE__*/t(\"ul\",{children:[/*#__PURE__*/e(\"li\",{\"data-preset-tag\":\"p\",children:/*#__PURE__*/e(\"p\",{children:\"Fast turnaround fungal resistant tests do take 28 days, hence laboratories ensure that they do not delay during set up or reporting.\"})}),/*#__PURE__*/e(\"li\",{\"data-preset-tag\":\"p\",children:/*#__PURE__*/e(\"p\",{children:\"Reliable control performance helps to know the ability of the surface to resist the fungi.\"})}),/*#__PURE__*/e(\"li\",{\"data-preset-tag\":\"p\",children:/*#__PURE__*/e(\"p\",{children:\"Imaging: fungal resistance tests rely mainly on visual rating systems to determine the performance.\"})})]})]});export const richText33=/*#__PURE__*/t(a.Fragment,{children:[/*#__PURE__*/t(\"p\",{children:[\"ARE Labs is proud to support \",/*#__PURE__*/e(i,{href:\"http://www.mriglobal.org/\",nodeId:\"JmhujK3L9\",openInNewTab:!1,smoothScroll:!1,children:/*#__PURE__*/e(\"a\",{children:\"MRI Global\"})}),\" in the Design, Development, Characterization and Execution of Bioaerosol a Vaccine Efficacy Study for \",/*#__PURE__*/e(\"em\",{children:\"Burkholderia mallei (glanders)\"}),\".\\xa0 The program was funded by \",/*#__PURE__*/e(i,{href:\"http://www.phe.gov/about/BARDA/Pages/default.aspx\",nodeId:\"JmhujK3L9\",openInNewTab:!1,smoothScroll:!1,children:/*#__PURE__*/e(\"a\",{children:\"Biomedical Advanced Research and Development Authority (BARDA)\"})}),\".\\xa0 ARE Labs provided critical study support which included the design and construction of a 12 port nose-only exposure system (murine animal model), validation and characterization of the exposure system with \",/*#__PURE__*/e(\"em\",{children:\"B. mallei, \"}),\"conduct of the\\xa0 exposures, and data analysis and reporting.\"]}),/*#__PURE__*/e(\"img\",{alt:\"\",className:\"framer-image\",\"data-framer-asset\":\"data:framer/asset-reference,fY3TlJELgCpyj3BSqusgq1Dqic.jpg\",\"data-framer-height\":\"182\",\"data-framer-width\":\"276\",height:\"91\",src:\"https://framerusercontent.com/images/fY3TlJELgCpyj3BSqusgq1Dqic.jpg\",style:{aspectRatio:\"276 / 182\"},width:\"138\"}),/*#__PURE__*/e(\"p\",{children:\"The system was constructed in MRI Global\u2019s BL3 safety Laboratory in a biological safety cabinet glove box.\\xa0 Flow monitoring and control systems were implemented for ease of adjustment, monitoring, and recording of system operation parameters.\\xa0 Following construction, the primary containment system and the aerosol challenge system were leak tested at positive pressure conditions with cabinet and system seals and penetrations monitored for leaks with smoke and liquid leak detectors. The aerosol generation, sampling system, flow controllers, and monitors were characterized and calibrated with a certified NIST traceable flow standard and results graphed for documentation.\\xa0 The system was characterized for aerosol generation, delivery, and exposure concentration homogeneity using NIST traceable polystyrene latex microsphere (PSL) standards of 1.0, 2.0, and 3.0 \u03BCm in diameter with each standard prepared individually in molecular grade water.\\xa0\\xa0 The PSL standards were aerosolized in independent tests using a Collison nebulizer with the system operating in a dynamic flow through mode at flow and pressures defined to conduct the exposure study.\"}),/*#__PURE__*/e(\"img\",{alt:\"\",className:\"framer-image\",\"data-framer-asset\":\"data:framer/asset-reference,ztRu468i8q65buJ5jDioHgGWC7s.jpg\",\"data-framer-height\":\"277\",\"data-framer-width\":\"182\",height:\"138\",src:\"https://framerusercontent.com/images/ztRu468i8q65buJ5jDioHgGWC7s.jpg\",style:{aspectRatio:\"182 / 277\"},width:\"91\"}),/*#__PURE__*/t(\"p\",{children:[\"The exposure system was operated in a dynamic push/pull flow mode at slight negative pressure.\\xa0 A TSI Aerodynamic Particle Sizer (APS) was used to measure the particle size distribution and count concentration homogeneity of at each of the twelve exposure locations of the nose only exposure system.\\xa0\\xa0 The APS data was regressed and concentrations and particle size for each of the PSL standards were verified to be within \\xb1 2% of the median concentration for aerosol delivery at each exposure location.\\xa0 Following the system characterization, we performed a pilot study to measure the viable aerosol system delivery and collection concentrations of \",/*#__PURE__*/e(\"em\",{children:\"B. mallei\"}),\" standards prepared at concentrations of 1 x 104, 1 x 106, and 1 x 108 colony forming units per mL (cfu/mL).\\xa0 Aerosol characterization trials for each of the three \",/*#__PURE__*/e(\"em\",{children:\"B. mallei\"}),\" standards were conducted in triplicate.\\xa0 Impinger samples were taken at a nose only aerosol delivery location of the system during each trial, and collected samples were serial diluted on agar plates, incubated for 48 to 72 hours, and enumerated for viable cfu collection to define the presented dose and exposure parameters for the study.\"]})]});export const richText34=/*#__PURE__*/t(a.Fragment,{children:[/*#__PURE__*/e(\"img\",{alt:\"\",className:\"framer-image\",\"data-framer-asset\":\"data:framer/asset-reference,ChPx7KFqRqx0ei5SegjfE8sLfVQ.jpg\",\"data-framer-height\":\"150\",\"data-framer-width\":\"150\",height:\"75\",src:\"https://framerusercontent.com/images/ChPx7KFqRqx0ei5SegjfE8sLfVQ.jpg\",style:{aspectRatio:\"150 / 150\"},width:\"75\"}),/*#__PURE__*/e(\"p\",{children:\"ARE Labs can provide a variety of custom test setup to perform bioaerosol decontamination efficacy testing.\\xa0 Whether testing your system in a room environment under recirculatory condition or determination of single pass decontamination efficacy against a variety of vegetative bacteria, viruses, bacteria and mold spores, or common allergens (pollen, dander, fibers, etc.).\"}),/*#__PURE__*/e(\"p\",{children:\"We can construct any aerosol challenge system required for your device to provide true real-world decontamination efficacy data under a wide variety of operating conditions and with a multitude of biological organisms including BSL3 surrogates.\"}),/*#__PURE__*/e(\"img\",{alt:\"\",className:\"framer-image\",\"data-framer-asset\":\"data:framer/asset-reference,DjyX2HqfTOg2fTdB3atQCPhWP4w.png\",\"data-framer-height\":\"38\",\"data-framer-width\":\"420\",height:\"19\",src:\"https://framerusercontent.com/images/DjyX2HqfTOg2fTdB3atQCPhWP4w.png\",style:{aspectRatio:\"420 / 38\"},width:\"210\"}),/*#__PURE__*/t(\"p\",{children:[/*#__PURE__*/e(i,{href:\"http://www.transformair.net/\",nodeId:\"JmhujK3L9\",openInNewTab:!0,smoothScroll:!1,children:/*#__PURE__*/e(\"a\",{children:\"TransformAir\\xa0\"})}),\" asked ARE Labs to provide testing and engineering support for their novel decontamination system and for efficacy testing in support for FDA 510(k) testing requirements.\\xa0 The TransformAir Unit is designed for purifying HVAC air of airborne contaminates including potentially infectious bioaerosols.\\xa0 The unit are designed for single pass air flow purification and have built in unidirectional air blowers for air flow control, and a proprietary catalytic coated filters and UV light sources for the capture and destruction of bio-aerosols using hydroxyl radicals.\\xa0 B\",/*#__PURE__*/e(\"em\",{children:\"iological aerosol decontamination testing \"}),\"was conducted in our Aerosol Testing Chamber (ATC).\\xa0 The ATC is designed for evaluating biological and chemical generation, sampling, detection and decontamination systems in a large scale environment.\\xa0 The test setup for this system is unique in the fact that the ATC serves as the secondary aerosol containment system for the primary challenge system.\\xa0 The challenge system is kept at a slightly negative pressure relative to the ATC.\\xa0 The primary challenge system is a push-pull design with multiple sampling ports upstream and downstream, sampling ports for real-time particle concentration and monitoring via a TSI Aerodynamic Particle Sizer (APS).\"]}),/*#__PURE__*/e(\"h4\",{children:/*#__PURE__*/e(\"em\",{children:/*#__PURE__*/e(\"strong\",{children:\"\u201CAerosol Science is our Specialty\u201D\"})})}),/*#__PURE__*/e(\"h2\",{children:\"Biological Aerosol Decontamination Testing\"}),/*#__PURE__*/e(\"img\",{alt:\"\",className:\"framer-image\",\"data-framer-asset\":\"data:framer/asset-reference,BOCx7N0vBP2vcxZcnygyQVcI.jpg\",\"data-framer-height\":\"839\",\"data-framer-width\":\"1190\",height:\"419\",src:\"https://framerusercontent.com/images/BOCx7N0vBP2vcxZcnygyQVcI.jpg\",srcSet:\"https://framerusercontent.com/images/BOCx7N0vBP2vcxZcnygyQVcI.jpg?scale-down-to=512 512w,https://framerusercontent.com/images/BOCx7N0vBP2vcxZcnygyQVcI.jpg?scale-down-to=1024 1024w,https://framerusercontent.com/images/BOCx7N0vBP2vcxZcnygyQVcI.jpg 1190w\",style:{aspectRatio:\"1190 / 839\"},width:\"595\"}),/*#__PURE__*/e(\"p\",{children:\"Testing is being conducted against a range of vegetative bacteria, viruses and spore forming organisms in support for FDA 510(k) requirements.\\xa0 ARE Labs designed and constructed a bioaerosol generation, delivery, and sampling system to accurately evaluate the efficacy of the TransformAir\u2019s ability to reducing viable bioaerosol contaminants in an HVAC environment.\\xa0 Bioaerosols were generated using jet nebulizers, custom dry aerosol generators.\\xa0 Aerosol samplers were collected simultaneously upstream and downstream of the test unit for viable aerosol challenge concentration and viable bioaerosol filter penetration measurements.\\xa0\\xa0 Samples were serial diluted and plated for viable cfu collection and test unit efficiency calculations in the reduction of viable bioaerosols. Aerosol particle size distribution measurements were taken at upstream and downstream locations of the test units in real time during testing for concentration and particle size comparison using an aerodynamic particle sizer (APS).\"}),/*#__PURE__*/e(\"p\",{children:/*#__PURE__*/e(\"em\",{children:\"ARE Labs specializes in custom engineering and testing projects.\\xa0 We would be honored to help you achieve your specific engineering and biological aerosol decontamination testing goals for Testing.\"})})]});export const richText35=/*#__PURE__*/t(a.Fragment,{children:[/*#__PURE__*/e(\"img\",{alt:\"\",className:\"framer-image\",\"data-framer-asset\":\"data:framer/asset-reference,yKtS24LMlKudfU95QMeRkV6S4hg.png\",\"data-framer-height\":\"150\",\"data-framer-width\":\"150\",height:\"75\",src:\"https://framerusercontent.com/images/yKtS24LMlKudfU95QMeRkV6S4hg.png\",style:{aspectRatio:\"150 / 150\"},width:\"75\"}),/*#__PURE__*/t(\"p\",{children:[\"ARE Labs was contracted by \",/*#__PURE__*/e(i,{href:\"http://www.hgiind.com/\",nodeId:\"JmhujK3L9\",openInNewTab:!0,smoothScroll:!1,children:/*#__PURE__*/e(\"a\",{children:\"HGI industries Inc.\"})}),\" for characterization and decontamination testing of a novel biological decontamination system the ODOROX\\xae (MDU) for cGLP \",/*#__PURE__*/e(i,{href:\"http://www.fda.gov/MedicalDevices/DeviceRegulationandGuidance/HowtoMarketYourDevice/PremarketSubmissions/PremarketNotification510k/ucm142651.htm\",nodeId:\"JmhujK3L9\",openInNewTab:!0,smoothScroll:!1,children:/*#__PURE__*/e(\"a\",{children:\"FDA 510(k) Application Requirement\"})}),\".\\xa0 Based on the testing results \",/*#__PURE__*/e(i,{href:\"http://www.accessdata.fda.gov/cdrh_docs/pdf13/k133800.pdf\",nodeId:\"JmhujK3L9\",openInNewTab:!0,smoothScroll:!1,children:/*#__PURE__*/e(\"a\",{children:\"FDA granted HGI industries\u2019 claims\"})}),\" for 4-log reduction of viable aerosolized: Bacteria (gram negative and positive), Viruses (DNA and RNA), spores (Bacillus globigi, surrogate for\\xa0 Bacillus Anthrisis; Anthrax) and mold spores.\\xa0\"]}),/*#__PURE__*/e(\"img\",{alt:\"\",className:\"framer-image\",\"data-framer-asset\":\"data:framer/asset-reference,oIMBjQtbQaP9ctotlJIdPomtO8.png\",\"data-framer-height\":\"120\",\"data-framer-width\":\"834\",height:\"60\",src:\"https://framerusercontent.com/images/oIMBjQtbQaP9ctotlJIdPomtO8.png\",srcSet:\"https://framerusercontent.com/images/oIMBjQtbQaP9ctotlJIdPomtO8.png?scale-down-to=512 512w,https://framerusercontent.com/images/oIMBjQtbQaP9ctotlJIdPomtO8.png 834w\",style:{aspectRatio:\"834 / 120\"},width:\"417\"}),/*#__PURE__*/e(\"img\",{alt:\"\",className:\"framer-image\",\"data-framer-asset\":\"data:framer/asset-reference,E0K1D8CzlsIjVmoRQU1moL7RIi4.jpg\",\"data-framer-height\":\"463\",\"data-framer-width\":\"621\",height:\"231\",src:\"https://framerusercontent.com/images/E0K1D8CzlsIjVmoRQU1moL7RIi4.jpg\",srcSet:\"https://framerusercontent.com/images/E0K1D8CzlsIjVmoRQU1moL7RIi4.jpg?scale-down-to=512 512w,https://framerusercontent.com/images/E0K1D8CzlsIjVmoRQU1moL7RIi4.jpg 621w\",style:{aspectRatio:\"621 / 463\"},width:\"310\"}),/*#__PURE__*/t(\"p\",{children:[/*#__PURE__*/e(i,{href:\"http://www.hgiind.com/products/mdu/\",nodeId:\"JmhujK3L9\",openInNewTab:!0,smoothScroll:!1,children:/*#__PURE__*/e(\"a\",{children:\"ODOROX\\xae\"})}),\" \\xa0\u2018s decontamination technology is based on hydroxyl radical generation via UV radiation.\\xa0 The System is design for use in patient recovery rooms for the destruction of airborne biological pathogens.\\xa0 This is very much an important area of development for recovery and continued well being of hospital patients and those with compromised immune systems.\\xa0 With the continued emergence of biological pathogens that have therapeutic and antibiotic resistance, this technology could have broad applications for reducing or eliminating the potential transmission of infectious disease from patient to patient and to hospital staff.\\xa0 The threat of aerosol transmission is of great concern due to the increased risk of infectivity via the inhalation route in relation to other transmission routes.\"]}),/*#__PURE__*/e(\"p\",{children:\"The testing was performed here at ARE Labs in our stainless steel biological/chemical aerosol and vapor containment chamber.\\xa0 Our Aerosol Test Chamber (ATC) is designed for evaluating biological and chemical generation, sampling, detection and decontamination systems in a large scale room-like environment.\\xa0 THE ATC is outfitted with multiple aerosol generators, sampling ports, mixing fans, and vaporous & aerosol hydrogen peroxide decontamination generator for testing biological and chemical decontamination efficacy.\\xa0 In addition, everyday objects found a hospital or residential can also be placed in the chamber with controlled leak rates to simulate a true real-world\\xa0 situations.\\xa0 Surface swatches and swabs can be performed to gather surface decontamination efficacy data is so desired.\"}),/*#__PURE__*/e(\"img\",{alt:\"\",className:\"framer-image\",\"data-framer-asset\":\"data:framer/asset-reference,dggnSqogSgTHaCMmeo8aghuzqug.jpg\",\"data-framer-height\":\"547\",\"data-framer-width\":\"1024\",height:\"273\",src:\"https://framerusercontent.com/images/dggnSqogSgTHaCMmeo8aghuzqug.jpg\",srcSet:\"https://framerusercontent.com/images/dggnSqogSgTHaCMmeo8aghuzqug.jpg?scale-down-to=512 512w,https://framerusercontent.com/images/dggnSqogSgTHaCMmeo8aghuzqug.jpg 1024w\",style:{aspectRatio:\"1024 / 547\"},width:\"512\"}),/*#__PURE__*/e(\"p\",{children:\"For this study we characterized the efficacy of HGI\u2019s MDU technology against six biological pathogen surrogate aerosols that included two vegetative bacteria (Gram pos & neg), two viral (RNA & DNA) and two spore forming organism (bacteria and mold).\\xa0\\xa0 The system was tested in a multi-pass recirculation mode for efficacy of reducing bioaerosols in a room environment by a magnitude of 4 logs against the 6 biological aerosols in individual test trials.\\xa0 Testing included baseline control test trials and three replicate MDU\u2122 test trials for each of the biologicals.\\xa0 The objective was to characterize the unit to determine capability to achieve a 4-log reduction in viable bioaerosols within 6 hour test period.\"}),/*#__PURE__*/e(\"img\",{alt:\"\",className:\"framer-image\",\"data-framer-asset\":\"data:framer/asset-reference,ZbST5wzJPXumHQJ1LMDcusHmTc.jpg\",\"data-framer-height\":\"768\",\"data-framer-width\":\"1024\",height:\"384\",src:\"https://framerusercontent.com/images/ZbST5wzJPXumHQJ1LMDcusHmTc.jpg\",srcSet:\"https://framerusercontent.com/images/ZbST5wzJPXumHQJ1LMDcusHmTc.jpg?scale-down-to=512 512w,https://framerusercontent.com/images/ZbST5wzJPXumHQJ1LMDcusHmTc.jpg 1024w\",style:{aspectRatio:\"1024 / 768\"},width:\"512\"}),/*#__PURE__*/e(\"p\",{children:\"We prepared working stock cultures of the biological test organisms and generated the aerosols in the respirable mass size range with appropriate aerosol sampling and real-time particle size monitoring of the Aerosol Test Chamber.\\xa0 Particle size distributions of each bioaerosol were measured throughout the duration of each trial using a TSI Aerodynamic Particle sizer.\\xa0\\xa0 Resultant aerosols for each biological showed \u2265 1\\xd7105 cfu or pfu/Lair viable airborne concentrations for each organism throughout the 6 hour time in conducted pilot control testing.\\xa0\\xa0 Concentrations were verified via impinger, filter or impactor sampling during the total trial period with triplicate plating and viable concentration emeration of the test samples.\"}),/*#__PURE__*/e(\"p\",{children:\"Characterization testing showed outstanding results with a total reduction of bioaerosol viability\\xa0 of 3.8-5 log (organism dependent) within a 2 hour period.\\xa0\\xa0 HGI was gracious in letting us post some of the results from testing their ODOROX\\xae MDU disinfection unit.\"}),/*#__PURE__*/e(\"p\",{children:\"ARE Lab\u2019s provides the highest quality standards in the testing and development of our clients products.\\xa0 From decades of experience in performing biological, chemical and environmental aerosol studies, we know the importance of designing systems, and study test plans and procedures that are customized specifically for the application of testing and evaluating our client\u2019s products.\"}),/*#__PURE__*/e(\"p\",{children:\"If you have any questions or would like to inquire on how we may support your products testing or development, please feel free to give us a call.\\xa0 We look forward to talking with you.\"})]});export const richText36=/*#__PURE__*/t(a.Fragment,{children:[/*#__PURE__*/e(\"img\",{alt:\"\",className:\"framer-image\",\"data-framer-asset\":\"data:framer/asset-reference,TTTKr74fGsXVgU9d6T0KEkCO4as.png\",\"data-framer-height\":\"816\",\"data-framer-width\":\"1024\",height:\"408\",src:\"https://framerusercontent.com/images/TTTKr74fGsXVgU9d6T0KEkCO4as.png\",srcSet:\"https://framerusercontent.com/images/TTTKr74fGsXVgU9d6T0KEkCO4as.png?scale-down-to=512 512w,https://framerusercontent.com/images/TTTKr74fGsXVgU9d6T0KEkCO4as.png 1024w\",style:{aspectRatio:\"1024 / 816\"},width:\"512\"}),/*#__PURE__*/e(\"p\",{children:\"ARE Labs constructed and performed computational fluid dynamics modeling for the Rollins7 Aerosol Adult Oxygen Mask System.\\xa0 The modeling was compared to test data and part of a FDA 510(k) submission package.\\xa0\\xa0 The 3D computation fluid dynamic model (CFD) incorporated custom code to allow the full 3D model to breath.\\xa0 Individual tidal volume, frequency and I:E ratios are able to be set to explore the effects they have on total drug delivery, oxygen delivery and carbon dioxide re-breathing to a patient.\\xa0 The model was confirmed via laboratory aerosol testing on a ventilated mannequin connected to a ventilator.\\xa0 Both resting male and female respiratory patterns were investigated for the CFD model and the aerosol testing.\\xa0 Testing confirmed the CFD computed aerosol drug delivery within 10% of modeling values.\"}),/*#__PURE__*/e(\"img\",{alt:\"\",className:\"framer-image\",\"data-framer-asset\":\"data:framer/asset-reference,R7Md2EaJQF2DdDuqVfb3AH8tkE.jpg\",\"data-framer-height\":\"117\",\"data-framer-width\":\"333\",height:\"58\",src:\"https://framerusercontent.com/images/R7Md2EaJQF2DdDuqVfb3AH8tkE.jpg\",style:{aspectRatio:\"333 / 117\"},width:\"166\"}),/*#__PURE__*/e(\"p\",{children:\"Rollins Medical receives approval letter from FDA regarding the 510(k) application for the Rollins7 Adult Oxygen Mask.\\xa0 ARE Labs was proud to provide FDA 510(k) testing and Computation Fluid Dynamics (CFD) Modeling support for Rollins Medical Solutions.\\xa0 The Rollins7 Adult Oxygen mask is a combination device which allows oxygen therapy and delivery of aerosolized drug via either a nebulizer or MDI simultaneously.\\xa0 The new innovative mask offers high delivery of aerosol medication while also allowing patient to imbibe drink and food through the open mouth port in the mask.\\xa0 The open port mask design also greatly enhances removal of carbon dioxide thus reducing CO2 re-breathing compared to other masks on the market.\"}),/*#__PURE__*/e(\"img\",{alt:\"\",className:\"framer-image\",\"data-framer-asset\":\"data:framer/asset-reference,8xJg8a5T3ssnhWYeBSYZmNWmAqA.jpg\",\"data-framer-height\":\"936\",\"data-framer-width\":\"936\",height:\"468\",src:\"https://framerusercontent.com/images/8xJg8a5T3ssnhWYeBSYZmNWmAqA.jpg\",srcSet:\"https://framerusercontent.com/images/8xJg8a5T3ssnhWYeBSYZmNWmAqA.jpg?scale-down-to=512 512w,https://framerusercontent.com/images/8xJg8a5T3ssnhWYeBSYZmNWmAqA.jpg 936w\",style:{aspectRatio:\"936 / 936\"},width:\"468\"}),/*#__PURE__*/e(\"p\",{children:\"ARE labs was contracted with Rollins Medical Solutions to provide FDA 510(k) testing support for their new Rollins7 Adult Oxygen Mask.\\xa0 The testing included cascade impactor studies to measure the total patient repairable dose received during a typical treatment time.\\xa0 Particle size analysis, MMAD and GSD of the aerosols was measured for multiple respiratory drugs using a cascade impactor.\\xa0\\xa0 The mask was also evaluated under a variety of respiratory conditions using a piston type ventilator and a human model to accurately measure the total dosage received to a typical patient.\\xa0\\xa0 All drug analysis was performed using an HPLC system with UV detection.\"}),/*#__PURE__*/e(\"p\",{children:\"ARE Labs provided computational fluid dynamics modeling (CFD) support for the Rollins7 Adult oxygen mask.\\xa0 The model was constructed using a 3D human model (breathing parameters were custumizable in the model to control tidal volume, frequency and I:E ratios of the human model).\\xa0 Aerosol and oxygen flows were controllable and set in the boundary condition of the model.\\xa0 The CFD model provided key insights to the function of the mask.\\xa0\\xa0 The CFD model confirmed testing results for aerosol drug delivery and provide additional data which is not easily obtained through traditional test methods.\\xa0 Primarily the model provided assessments of\\xa0 patient oxygen enrichment, carbon dioxide elimination and temperature gradients of the mask under a variety of oxygen flows, aerosol mass rates and patient breathing conditions. \\xa0\\xa0\\xa0 Several pictures and an animation of the CFD model are shown.\"}),/*#__PURE__*/e(\"p\",{children:\"ARE Labs combines design, formulation, testing, rapid prototyping\\xa0 and computation fluid dynamics modeling under one roof for our clients.\\xa0 This set of in-house abilities allows ARE Labs to bring a complete respiratory drug delivery package to our clients with exceptional cost saving and speed to market.\"}),/*#__PURE__*/t(\"p\",{children:[\"The Rollins7 Oxygen Mask is a next-generation mask to deliver aerosolized medication via nebulizer and metered dose inhalers while providing oxygen therapy.\\xa0 The mask provides very high oxygen delivery and carbon dioxide removal through it innovative open port design, which other oxygen masks lack.\\xa0 The multi-function design and delivery performance is what makes the Rollins7 Oxygen mask a next-generation respiratory therapy device.\\xa0 Please visit the \",/*#__PURE__*/e(i,{href:\"http://www.r7mask.com/\",nodeId:\"JmhujK3L9\",openInNewTab:!0,smoothScroll:!1,children:/*#__PURE__*/e(\"a\",{children:\"Rollins Medical Solutions\"})}),\" to learn more about their innovative solutions for the 21st century.\"]})]});export const richText37=/*#__PURE__*/t(a.Fragment,{children:[/*#__PURE__*/e(\"h3\",{children:\"ARE Labs has been recently granted a Schedule 1 Research Drug License approved by DEA, NIH/NIDA & FDA for research into the feasibility of delivery of THC and THC-CBD via dry powder for Marinol\\xae and Medical Marijuana.\\xa0\"}),/*#__PURE__*/e(\"img\",{alt:\"\",className:\"framer-image\",\"data-framer-asset\":\"data:framer/asset-reference,5VSdKr5YE09G93LVXpSgN2cGQ.jpg\",\"data-framer-height\":\"438\",\"data-framer-width\":\"700\",height:\"219\",src:\"https://framerusercontent.com/images/5VSdKr5YE09G93LVXpSgN2cGQ.jpg\",srcSet:\"https://framerusercontent.com/images/5VSdKr5YE09G93LVXpSgN2cGQ.jpg?scale-down-to=512 512w,https://framerusercontent.com/images/5VSdKr5YE09G93LVXpSgN2cGQ.jpg 700w\",style:{aspectRatio:\"700 / 438\"},width:\"350\"}),/*#__PURE__*/t(\"p\",{children:[\"The approved research study entitled Research into the Feasibility for Development of a Therapeutic Respiratory Delivery of THC and a THC-CBD Combination Drug via Dry Powder Inhaler will commence in Q4 of 2015.\\xa0 The study will be conducted at ARE Labs to test the feasibility using a THC dry powder inhaler delivery method for THC and a dual THC-CBD drug combination to the alveolar regions of the lungs.\\xa0 Partial funding for the project will be provided by \",/*#__PURE__*/e(i,{href:\"http://www.serologix.com/\",nodeId:\"JmhujK3L9\",openInNewTab:!0,smoothScroll:!1,children:/*#__PURE__*/e(\"a\",{children:\"Serologix, LLC\"})}),\" (San Diego, CA).\\xa0 Dry powder aerosol drug development is one of ARE Labs specialties and hopes to mitigate the problems associated with orally delivered THC products.\\xa0 The study will use \",/*#__PURE__*/e(i,{href:\"http://www.marinol.com/\",nodeId:\"JmhujK3L9\",openInNewTab:!0,smoothScroll:!1,children:/*#__PURE__*/e(\"a\",{children:\"Marinol\"})}),\" developed by \",/*#__PURE__*/e(i,{href:\"http://www.abbvie.com/products/home.html\",nodeId:\"JmhujK3L9\",openInNewTab:!0,smoothScroll:!1,children:/*#__PURE__*/e(\"a\",{children:\"AbbVie Pharmaceutical\"})}),\" (Chicago, IL) and THC-CBD dual combination drug formulation from whole plant extract.\\xa0\"]}),/*#__PURE__*/e(\"img\",{alt:\"\",className:\"framer-image\",\"data-framer-asset\":\"data:framer/asset-reference,9zV2X748aBH9Pq87LGYc4m7Vb4c.jpg\",\"data-framer-height\":\"321\",\"data-framer-width\":\"920\",height:\"160\",src:\"https://framerusercontent.com/images/9zV2X748aBH9Pq87LGYc4m7Vb4c.jpg\",srcSet:\"https://framerusercontent.com/images/9zV2X748aBH9Pq87LGYc4m7Vb4c.jpg?scale-down-to=512 512w,https://framerusercontent.com/images/9zV2X748aBH9Pq87LGYc4m7Vb4c.jpg 920w\",style:{aspectRatio:\"920 / 321\"},width:\"460\"}),/*#__PURE__*/t(\"p\",{children:[\"It has been noted in multiple research articles that THC and cannabinoid extracts from Marijuana have therapeutic benefits for MS patients, chronic pain sufferers, cancer, and AIDS patients.\\xa0 One key objective is to investigate a combination THC\u2013CBD drug that can be delivered in a respirable form to patients that will be more effective, have better dose control, and have enhanced efficiency in delivery and therapeutic effect than current methods. The clinical significance of this development could lead to controlled and reproducible dose delivery and a more effective method for patients that are provided medical marijuana or \",/*#__PURE__*/e(i,{href:\"http://jat.oxfordjournals.org/content/23/3/222.short\",nodeId:\"JmhujK3L9\",openInNewTab:!1,smoothScroll:!1,children:/*#__PURE__*/e(\"a\",{children:\"Marinol\\xae\"})}),\" (synthetic THC) which are currently available by prescription.\"]}),/*#__PURE__*/e(\"img\",{alt:\"\",className:\"framer-image\",\"data-framer-asset\":\"data:framer/asset-reference,aAOlyJE9NiMmrnzhNeYpDvicrl8.jpg\",\"data-framer-height\":\"200\",\"data-framer-width\":\"338\",height:\"100\",src:\"https://framerusercontent.com/images/aAOlyJE9NiMmrnzhNeYpDvicrl8.jpg\",style:{aspectRatio:\"338 / 200\"},width:\"169\"}),/*#__PURE__*/e(\"p\",{children:\"The proposed dry powder delivery platform would provide direct delivery of drug to the alveolar region of the lungs for direct absorption into the systemic circulation system providing much greater bio-availability than an oral dose, and provide the same therapeutic effect at lower concentrations of delivered drug.\\xa0 The methods to generate the THC dry powder inhaler particles will involve mufti-tiered approach consisting of:\\xa0 Loading and Encapsulation onto to FDA approved excipients, Spray Drying, Jet Milling, Cyclone Elutriation , Charge Masking and Surfactant Coatings.\\xa0 The studies initial phases will investigate loading ratios, particle size, stability and delivery of drug to a human model (ventilated mannequin with controllable tidal volume, I:E ratios and breathing rates).\"}),/*#__PURE__*/e(\"img\",{alt:\"\",className:\"framer-image\",\"data-framer-asset\":\"data:framer/asset-reference,AW4Pm75tUeGI3Pzg0XxsiQirXk.jpg\",\"data-framer-height\":\"223\",\"data-framer-width\":\"300\",height:\"111\",src:\"https://framerusercontent.com/images/AW4Pm75tUeGI3Pzg0XxsiQirXk.jpg\",style:{aspectRatio:\"300 / 223\"},width:\"150\"}),/*#__PURE__*/t(\"p\",{children:[\"THC dry powder inhaler feasibility study will be conducted in a two Phase process (Phase 1A & 1B).\\xa0 Phase 1A will be to examine the feasibility of developing a dry powder inhalation formulation using \",/*#__PURE__*/e(i,{href:\"http://jat.oxfordjournals.org/content/23/3/222.short\",nodeId:\"JmhujK3L9\",openInNewTab:!1,smoothScroll:!1,children:/*#__PURE__*/e(\"a\",{children:\"Marinol\\xae\"})}),\" (synthetic THC) which is currently available by prescription. Marinol\\xae is currently an orally administered synthetically derived \u03949-THC prescription.\\xa0 Phase 1B will examine the feasibility of developing a dry powder formulation using whole plant extract, as a surrogate, for THC-CBD combination drug dry powder.\"]}),/*#__PURE__*/e(\"p\",{children:\"Aerosol Research and Engineering is excited to be involved with investigating a new dry powder delivery method for THC and THC-CBD combination drug which will give a wide variety of patients options for managing and treating their ailments with reduced side-effects and lower overall systematic doses compared with currently orally available medications.\"})]});\nexport const __FramerMetadata__ = {\"exports\":{\"richText1\":{\"type\":\"variable\",\"annotations\":{\"framerContractVersion\":\"1\"}},\"richText6\":{\"type\":\"variable\",\"annotations\":{\"framerContractVersion\":\"1\"}},\"richText12\":{\"type\":\"variable\",\"annotations\":{\"framerContractVersion\":\"1\"}},\"richText17\":{\"type\":\"variable\",\"annotations\":{\"framerContractVersion\":\"1\"}},\"richText11\":{\"type\":\"variable\",\"annotations\":{\"framerContractVersion\":\"1\"}},\"richText\":{\"type\":\"variable\",\"annotations\":{\"framerContractVersion\":\"1\"}},\"richText24\":{\"type\":\"variable\",\"annotations\":{\"framerContractVersion\":\"1\"}},\"richText34\":{\"type\":\"variable\",\"annotations\":{\"framerContractVersion\":\"1\"}},\"richText18\":{\"type\":\"variable\",\"annotations\":{\"framerContractVersion\":\"1\"}},\"richText2\":{\"type\":\"variable\",\"annotations\":{\"framerContractVersion\":\"1\"}},\"richText28\":{\"type\":\"variable\",\"annotations\":{\"framerContractVersion\":\"1\"}},\"richText30\":{\"type\":\"variable\",\"annotations\":{\"framerContractVersion\":\"1\"}},\"richText10\":{\"type\":\"variable\",\"annotations\":{\"framerContractVersion\":\"1\"}},\"richText8\":{\"type\":\"variable\",\"annotations\":{\"framerContractVersion\":\"1\"}},\"richText35\":{\"type\":\"variable\",\"annotations\":{\"framerContractVersion\":\"1\"}},\"richText25\":{\"type\":\"variable\",\"annotations\":{\"framerContractVersion\":\"1\"}},\"richText4\":{\"type\":\"variable\",\"annotations\":{\"framerContractVersion\":\"1\"}},\"richText33\":{\"type\":\"variable\",\"annotations\":{\"framerContractVersion\":\"1\"}},\"richText32\":{\"type\":\"variable\",\"annotations\":{\"framerContractVersion\":\"1\"}},\"richText23\":{\"type\":\"variable\",\"annotations\":{\"framerContractVersion\":\"1\"}},\"richText9\":{\"type\":\"variable\",\"annotations\":{\"framerContractVersion\":\"1\"}},\"richText29\":{\"type\":\"variable\",\"annotations\":{\"framerContractVersion\":\"1\"}},\"richText31\":{\"type\":\"variable\",\"annotations\":{\"framerContractVersion\":\"1\"}},\"richText22\":{\"type\":\"variable\",\"annotations\":{\"framerContractVersion\":\"1\"}},\"richText13\":{\"type\":\"variable\",\"annotations\":{\"framerContractVersion\":\"1\"}},\"richText37\":{\"type\":\"variable\",\"annotations\":{\"framerContractVersion\":\"1\"}},\"richText5\":{\"type\":\"variable\",\"annotations\":{\"framerContractVersion\":\"1\"}},\"richText27\":{\"type\":\"variable\",\"annotations\":{\"framerContractVersion\":\"1\"}},\"richText3\":{\"type\":\"variable\",\"annotations\":{\"framerContractVersion\":\"1\"}},\"richText26\":{\"type\":\"variable\",\"annotations\":{\"framerContractVersion\":\"1\"}},\"richText14\":{\"type\":\"variable\",\"annotations\":{\"framerContractVersion\":\"1\"}},\"richText36\":{\"type\":\"variable\",\"annotations\":{\"framerContractVersion\":\"1\"}},\"richText16\":{\"type\":\"variable\",\"annotations\":{\"framerContractVersion\":\"1\"}},\"richText15\":{\"type\":\"variable\",\"annotations\":{\"framerContractVersion\":\"1\"}},\"richText7\":{\"type\":\"variable\",\"annotations\":{\"framerContractVersion\":\"1\"}},\"richText21\":{\"type\":\"variable\",\"annotations\":{\"framerContractVersion\":\"1\"}},\"richText19\":{\"type\":\"variable\",\"annotations\":{\"framerContractVersion\":\"1\"}},\"richText20\":{\"type\":\"variable\",\"annotations\":{\"framerContractVersion\":\"1\"}},\"__FramerMetadata__\":{\"type\":\"variable\"}}}"],
  "mappings": "yHAA+G,IAAMA,EAAsBC,EAAIC,EAAS,CAAC,SAAS,CAAcC,EAAE,IAAI,CAAC,SAAsBA,EAAE,KAAK,CAAC,SAAsBA,EAAE,SAAS,CAAC,SAAS,iCAAiC,CAAC,CAAC,CAAC,CAAC,CAAC,EAAeF,EAAE,KAAK,CAAC,SAAS,CAAcE,EAAE,KAAK,CAAC,kBAAkB,IAAI,SAAsBF,EAAE,IAAI,CAAC,SAAS,CAAcE,EAAE,SAAS,CAAC,SAAS,mBAAmB,CAAC,EAAE,+HAA+H,CAAC,CAAC,CAAC,CAAC,EAAeA,EAAE,KAAK,CAAC,kBAAkB,IAAI,SAAsBF,EAAE,IAAI,CAAC,SAAS,CAAcE,EAAE,SAAS,CAAC,SAAS,iBAAiB,CAAC,EAAE,wGAAwG,CAAC,CAAC,CAAC,CAAC,EAAeA,EAAE,KAAK,CAAC,kBAAkB,IAAI,SAAsBF,EAAE,IAAI,CAAC,SAAS,CAAcE,EAAE,SAAS,CAAC,SAAS,4BAA4B,CAAC,EAAE,gHAAgH,CAAC,CAAC,CAAC,CAAC,EAAeA,EAAE,KAAK,CAAC,kBAAkB,IAAI,SAAsBF,EAAE,IAAI,CAAC,SAAS,CAAcE,EAAE,SAAS,CAAC,SAAS,6BAA6B,CAAC,EAAE,4KAA4K,CAAC,CAAC,CAAC,CAAC,CAAC,CAAC,CAAC,EAAeA,EAAE,IAAI,CAAC,SAAsBA,EAAE,KAAK,CAAC,SAAsBA,EAAE,SAAS,CAAC,SAAS,MAAM,CAAC,CAAC,CAAC,CAAC,CAAC,EAAeA,EAAE,IAAI,CAAC,SAAsBA,EAAE,KAAK,CAAC,SAAsBA,EAAE,SAAS,CAAC,SAAS,uCAAuC,CAAC,CAAC,CAAC,CAAC,CAAC,EAAeA,EAAE,IAAI,CAAC,SAAS,oQAAoQ,CAAC,EAAeA,EAAE,IAAI,CAAC,SAAsBA,EAAE,KAAK,CAAC,SAAsBA,EAAE,SAAS,CAAC,SAAS,kCAAkC,CAAC,CAAC,CAAC,CAAC,CAAC,EAAeA,EAAE,IAAI,CAAC,SAAS,iUAAiU,CAAC,EAAeA,EAAE,IAAI,CAAC,SAAsBA,EAAE,KAAK,CAAC,SAAsBA,EAAE,SAAS,CAAC,SAAS,+BAA+B,CAAC,CAAC,CAAC,CAAC,CAAC,EAAeF,EAAE,KAAK,CAAC,SAAS,CAAcE,EAAE,KAAK,CAAC,kBAAkB,IAAI,SAAsBF,EAAE,IAAI,CAAC,SAAS,CAAcE,EAAE,SAAS,CAAC,SAAS,YAAY,CAAC,EAAE,iHAAiH,CAAC,CAAC,CAAC,CAAC,EAAeA,EAAE,KAAK,CAAC,kBAAkB,IAAI,SAAsBF,EAAE,IAAI,CAAC,SAAS,CAAcE,EAAE,SAAS,CAAC,SAAS,sBAAsB,CAAC,EAAE,4HAA4H,CAAC,CAAC,CAAC,CAAC,EAAeA,EAAE,KAAK,CAAC,kBAAkB,IAAI,SAAsBF,EAAE,IAAI,CAAC,SAAS,CAAcE,EAAE,SAAS,CAAC,SAAS,wBAAwB,CAAC,EAAE,2HAA2H,CAAC,CAAC,CAAC,CAAC,CAAC,CAAC,CAAC,EAAeA,EAAE,IAAI,CAAC,SAAsBA,EAAE,KAAK,CAAC,SAAsBA,EAAE,SAAS,CAAC,SAAS,2CAA2C,CAAC,CAAC,CAAC,CAAC,CAAC,EAAeA,EAAE,IAAI,CAAC,SAAS,wVAAwV,CAAC,CAAC,CAAC,CAAC,EAAeC,EAAuBD,EAAID,EAAS,CAAC,SAAsBC,EAAE,IAAI,CAAC,SAAsBA,EAAE,KAAK,CAAC,SAAS,mFAAmF,CAAC,CAAC,CAAC,CAAC,CAAC,EAAeE,EAAuBJ,EAAIC,EAAS,CAAC,SAAS,CAAcC,EAAE,IAAI,CAAC,SAAsBA,EAAE,KAAK,CAAC,SAAsBA,EAAE,SAAS,CAAC,SAAS,yCAAyC,CAAC,CAAC,CAAC,CAAC,CAAC,EAAeA,EAAE,IAAI,CAAC,SAAS,waAAwa,CAAC,EAAeA,EAAE,IAAI,CAAC,SAAS,uZAAuZ,CAAC,EAAeA,EAAE,IAAI,CAAC,SAAsBA,EAAE,KAAK,CAAC,SAAsBA,EAAE,SAAS,CAAC,SAAS,YAAY,CAAC,CAAC,CAAC,CAAC,CAAC,EAAeA,EAAE,IAAI,CAAC,SAAS,gdAAgd,CAAC,CAAC,CAAC,CAAC,EAAeG,EAAuBL,EAAIC,EAAS,CAAC,SAAS,CAAcC,EAAE,IAAI,CAAC,SAAS,+BAA+B,CAAC,EAAeF,EAAE,IAAI,CAAC,SAAS,CAAC,IAAiBE,EAAE,KAAK,CAAC,SAAS,yEAAyE,CAAC,CAAC,CAAC,CAAC,EAAeA,EAAE,IAAI,CAAC,SAAsBA,EAAE,SAAS,CAAC,SAAS,MAAM,CAAC,CAAC,CAAC,EAAeA,EAAE,KAAK,CAAC,SAAsBA,EAAE,SAAS,CAAC,SAAS,iDAAiD,CAAC,CAAC,CAAC,EAAeA,EAAE,IAAI,CAAC,SAAS,khBAAkhB,CAAC,EAAeA,EAAE,KAAK,CAAC,SAAsBA,EAAE,SAAS,CAAC,SAAS,kDAAkD,CAAC,CAAC,CAAC,EAAeA,EAAE,IAAI,CAAC,SAAS,2FAA2F,CAAC,EAAeF,EAAE,KAAK,CAAC,SAAS,CAAcE,EAAE,KAAK,CAAC,kBAAkB,IAAI,SAAsBF,EAAE,IAAI,CAAC,SAAS,CAAcE,EAAE,SAAS,CAAC,SAAS,iBAAiB,CAAC,EAAE,iIAAiI,CAAC,CAAC,CAAC,CAAC,EAAeA,EAAE,KAAK,CAAC,kBAAkB,IAAI,SAAsBF,EAAE,IAAI,CAAC,SAAS,CAAcE,EAAE,SAAS,CAAC,SAAS,aAAa,CAAC,EAAE,6GAA6G,CAAC,CAAC,CAAC,CAAC,EAAeA,EAAE,KAAK,CAAC,kBAAkB,IAAI,SAAsBF,EAAE,IAAI,CAAC,SAAS,CAAcE,EAAE,SAAS,CAAC,SAAS,cAAc,CAAC,EAAE,gGAAgG,CAAC,CAAC,CAAC,CAAC,EAAeA,EAAE,KAAK,CAAC,kBAAkB,IAAI,SAAsBF,EAAE,IAAI,CAAC,SAAS,CAAcE,EAAE,SAAS,CAAC,SAAS,sBAAsB,CAAC,EAAE,+HAA+H,CAAC,CAAC,CAAC,CAAC,CAAC,CAAC,CAAC,EAAeA,EAAE,KAAK,CAAC,SAAsBA,EAAE,SAAS,CAAC,SAAS,8DAA8D,CAAC,CAAC,CAAC,EAAeA,EAAE,IAAI,CAAC,SAAS,uMAAuM,CAAC,EAAeF,EAAE,KAAK,CAAC,SAAS,CAAcA,EAAE,KAAK,CAAC,kBAAkB,IAAI,SAAS,CAAcA,EAAE,IAAI,CAAC,SAAS,CAAcE,EAAE,SAAS,CAAC,SAAS,yCAAyC,CAAC,EAAE,GAAG,CAAC,CAAC,EAAeF,EAAE,KAAK,CAAC,SAAS,CAAcE,EAAE,KAAK,CAAC,kBAAkB,IAAI,SAAsBA,EAAE,IAAI,CAAC,SAAsBA,EAAEI,EAAE,CAAC,KAAK,wEAAwE,OAAO,YAAY,aAAa,GAAG,aAAa,GAAG,SAAsBJ,EAAE,IAAI,CAAC,SAAsBA,EAAE,SAAS,CAAC,SAAS,kEAAkE,CAAC,CAAC,CAAC,CAAC,CAAC,CAAC,CAAC,CAAC,CAAC,EAAeA,EAAE,KAAK,CAAC,kBAAkB,IAAI,SAAsBA,EAAE,IAAI,CAAC,SAAsBA,EAAEI,EAAE,CAAC,KAAK,8EAA8E,OAAO,YAAY,aAAa,GAAG,aAAa,GAAG,SAAsBJ,EAAE,IAAI,CAAC,SAAsBA,EAAE,SAAS,CAAC,SAAS,qEAAqE,CAAC,CAAC,CAAC,CAAC,CAAC,CAAC,CAAC,CAAC,CAAC,EAAeA,EAAE,KAAK,CAAC,kBAAkB,IAAI,SAAsBA,EAAE,IAAI,CAAC,SAAsBA,EAAEI,EAAE,CAAC,KAAK,oKAAoK,OAAO,YAAY,aAAa,GAAG,aAAa,GAAG,SAAsBJ,EAAE,IAAI,CAAC,SAAsBA,EAAE,SAAS,CAAC,SAAS,kGAAkG,CAAC,CAAC,CAAC,CAAC,CAAC,CAAC,CAAC,CAAC,CAAC,CAAC,CAAC,CAAC,CAAC,CAAC,CAAC,EAAeF,EAAE,KAAK,CAAC,kBAAkB,IAAI,SAAS,CAAcA,EAAE,IAAI,CAAC,SAAS,CAAcE,EAAE,SAAS,CAAC,SAAS,iCAAiC,CAAC,EAAE,GAAG,CAAC,CAAC,EAAeF,EAAE,KAAK,CAAC,SAAS,CAAcE,EAAE,KAAK,CAAC,kBAAkB,IAAI,SAAsBA,EAAE,IAAI,CAAC,SAAsBA,EAAEI,EAAE,CAAC,KAAK,qGAAqG,OAAO,YAAY,aAAa,GAAG,aAAa,GAAG,SAAsBJ,EAAE,IAAI,CAAC,SAAsBA,EAAE,SAAS,CAAC,SAAS,0EAA0E,CAAC,CAAC,CAAC,CAAC,CAAC,CAAC,CAAC,CAAC,CAAC,EAAeA,EAAE,KAAK,CAAC,kBAAkB,IAAI,SAAsBA,EAAE,IAAI,CAAC,SAAsBA,EAAEI,EAAE,CAAC,KAAK,kFAAkF,OAAO,YAAY,aAAa,GAAG,aAAa,GAAG,SAAsBJ,EAAE,IAAI,CAAC,SAAsBA,EAAE,SAAS,CAAC,SAAS,mFAAmF,CAAC,CAAC,CAAC,CAAC,CAAC,CAAC,CAAC,CAAC,CAAC,CAAC,CAAC,CAAC,CAAC,CAAC,CAAC,EAAeF,EAAE,KAAK,CAAC,kBAAkB,IAAI,SAAS,CAAcA,EAAE,IAAI,CAAC,SAAS,CAAcE,EAAE,SAAS,CAAC,SAAS,+CAA+C,CAAC,EAAE,GAAG,CAAC,CAAC,EAAeA,EAAE,KAAK,CAAC,SAAsBA,EAAE,KAAK,CAAC,kBAAkB,IAAI,SAAsBA,EAAE,IAAI,CAAC,SAAsBA,EAAEI,EAAE,CAAC,KAAK,yKAAyK,OAAO,YAAY,aAAa,GAAG,aAAa,GAAG,SAAsBJ,EAAE,IAAI,CAAC,SAAsBA,EAAE,SAAS,CAAC,SAAS,gHAAgH,CAAC,CAAC,CAAC,CAAC,CAAC,CAAC,CAAC,CAAC,CAAC,CAAC,CAAC,CAAC,CAAC,CAAC,CAAC,CAAC,CAAC,CAAC,CAAC,CAAC,EAAeK,EAAuBP,EAAIC,EAAS,CAAC,SAAS,CAAcC,EAAE,KAAK,CAAC,SAAsBA,EAAE,SAAS,CAAC,SAAS,4CAA4C,CAAC,CAAC,CAAC,EAAeA,EAAE,IAAI,CAAC,SAAS,uLAAuL,CAAC,EAAeF,EAAE,KAAK,CAAC,SAAS,CAAcA,EAAE,KAAK,CAAC,kBAAkB,IAAI,SAAS,CAAcA,EAAE,IAAI,CAAC,SAAS,CAAcE,EAAE,SAAS,CAAC,SAAS,+CAA+C,CAAC,EAAE,GAAG,CAAC,CAAC,EAAeF,EAAE,KAAK,CAAC,SAAS,CAAcE,EAAE,KAAK,CAAC,kBAAkB,IAAI,SAAsBA,EAAE,IAAI,CAAC,SAAS,0HAA0H,CAAC,CAAC,CAAC,EAAeA,EAAE,KAAK,CAAC,kBAAkB,IAAI,SAAsBF,EAAE,IAAI,CAAC,SAAS,CAAcE,EAAE,SAAS,CAAC,SAAS,mBAAmB,CAAC,EAAE,+GAA+G,CAAC,CAAC,CAAC,CAAC,EAAeA,EAAE,KAAK,CAAC,kBAAkB,IAAI,SAAsBF,EAAE,IAAI,CAAC,SAAS,CAAC,IAAiBE,EAAE,SAAS,CAAC,SAAS,mBAAmB,CAAC,EAAE,yIAAyI,CAAC,CAAC,CAAC,CAAC,CAAC,CAAC,CAAC,CAAC,CAAC,CAAC,EAAeF,EAAE,KAAK,CAAC,kBAAkB,IAAI,SAAS,CAAcA,EAAE,IAAI,CAAC,SAAS,CAAcE,EAAE,SAAS,CAAC,SAAS,iCAAiC,CAAC,EAAE,GAAG,CAAC,CAAC,EAAeF,EAAE,KAAK,CAAC,SAAS,CAAcE,EAAE,KAAK,CAAC,kBAAkB,IAAI,SAAsBA,EAAE,IAAI,CAAC,SAAS,yGAAyG,CAAC,CAAC,CAAC,EAAeA,EAAE,KAAK,CAAC,kBAAkB,IAAI,SAAsBF,EAAE,IAAI,CAAC,SAAS,CAAcE,EAAE,SAAS,CAAC,SAAS,oBAAoB,CAAC,EAAE,uFAAuF,CAAC,CAAC,CAAC,CAAC,CAAC,CAAC,CAAC,CAAC,CAAC,CAAC,EAAeF,EAAE,KAAK,CAAC,kBAAkB,IAAI,SAAS,CAAcA,EAAE,IAAI,CAAC,SAAS,CAAcE,EAAE,SAAS,CAAC,SAAS,cAAc,CAAC,EAAE,GAAG,CAAC,CAAC,EAAeF,EAAE,KAAK,CAAC,SAAS,CAAcE,EAAE,KAAK,CAAC,kBAAkB,IAAI,SAAsBA,EAAE,IAAI,CAAC,SAAS,sFAAsF,CAAC,CAAC,CAAC,EAAeA,EAAE,KAAK,CAAC,kBAAkB,IAAI,SAAsBF,EAAE,IAAI,CAAC,SAAS,CAAcE,EAAE,SAAS,CAAC,SAAS,mBAAmB,CAAC,EAAE,uGAAuG,CAAC,CAAC,CAAC,CAAC,CAAC,CAAC,CAAC,CAAC,CAAC,CAAC,EAAeF,EAAE,KAAK,CAAC,kBAAkB,IAAI,SAAS,CAAcA,EAAE,IAAI,CAAC,SAAS,CAAcE,EAAE,SAAS,CAAC,SAAS,8BAA8B,CAAC,EAAE,GAAG,CAAC,CAAC,EAAeF,EAAE,KAAK,CAAC,SAAS,CAAcE,EAAE,KAAK,CAAC,kBAAkB,IAAI,SAAsBA,EAAE,IAAI,CAAC,SAAS,+GAA+G,CAAC,CAAC,CAAC,EAAeA,EAAE,KAAK,CAAC,kBAAkB,IAAI,SAAsBF,EAAE,IAAI,CAAC,SAAS,CAAcE,EAAE,SAAS,CAAC,SAAS,sBAAsB,CAAC,EAAE,iHAAiH,CAAC,CAAC,CAAC,CAAC,CAAC,CAAC,CAAC,CAAC,CAAC,CAAC,EAAeF,EAAE,KAAK,CAAC,kBAAkB,IAAI,SAAS,CAAcA,EAAE,IAAI,CAAC,SAAS,CAAcE,EAAE,SAAS,CAAC,SAAS,mBAAmB,CAAC,EAAE,GAAG,CAAC,CAAC,EAAeF,EAAE,KAAK,CAAC,SAAS,CAAcE,EAAE,KAAK,CAAC,kBAAkB,IAAI,SAAsBA,EAAE,IAAI,CAAC,SAAS,mIAAmI,CAAC,CAAC,CAAC,EAAeA,EAAE,KAAK,CAAC,kBAAkB,IAAI,SAAsBF,EAAE,IAAI,CAAC,SAAS,CAAcE,EAAE,SAAS,CAAC,SAAS,+BAA+B,CAAC,EAAE,uHAAuH,CAAC,CAAC,CAAC,CAAC,CAAC,CAAC,CAAC,CAAC,CAAC,CAAC,EAAeF,EAAE,KAAK,CAAC,kBAAkB,IAAI,SAAS,CAAcA,EAAE,IAAI,CAAC,SAAS,CAAcE,EAAE,SAAS,CAAC,SAAS,wBAAwB,CAAC,EAAE,GAAG,CAAC,CAAC,EAAeF,EAAE,KAAK,CAAC,SAAS,CAAcE,EAAE,KAAK,CAAC,kBAAkB,IAAI,SAAsBA,EAAE,IAAI,CAAC,SAAS,yGAAyG,CAAC,CAAC,CAAC,EAAeA,EAAE,KAAK,CAAC,kBAAkB,IAAI,SAAsBF,EAAE,IAAI,CAAC,SAAS,CAAcE,EAAE,SAAS,CAAC,SAAS,qBAAqB,CAAC,EAAE,gHAAgH,CAAC,CAAC,CAAC,CAAC,CAAC,CAAC,CAAC,CAAC,CAAC,CAAC,CAAC,CAAC,CAAC,CAAC,CAAC,CAAC,EAAeM,EAAuBR,EAAIC,EAAS,CAAC,SAAS,CAAcC,EAAE,KAAK,CAAC,SAAsBA,EAAE,SAAS,CAAC,SAAS,0DAA0D,CAAC,CAAC,CAAC,EAAeA,EAAE,IAAI,CAAC,SAAS,4IAAuI,CAAC,EAAeF,EAAE,KAAK,CAAC,SAAS,CAAcE,EAAE,KAAK,CAAC,kBAAkB,IAAI,SAAsBF,EAAE,IAAI,CAAC,SAAS,CAAcE,EAAE,SAAS,CAAC,SAAS,6BAA6B,CAAC,EAAE,8HAA8H,CAAC,CAAC,CAAC,CAAC,EAAeA,EAAE,KAAK,CAAC,kBAAkB,IAAI,SAAsBF,EAAE,IAAI,CAAC,SAAS,CAAcE,EAAE,SAAS,CAAC,SAAS,aAAa,CAAC,EAAE,kJAAkJ,CAAC,CAAC,CAAC,CAAC,EAAeA,EAAE,KAAK,CAAC,kBAAkB,IAAI,SAAsBF,EAAE,IAAI,CAAC,SAAS,CAAcE,EAAE,SAAS,CAAC,SAAS,uBAAuB,CAAC,EAAE,6IAA6I,CAAC,CAAC,CAAC,CAAC,EAAeA,EAAE,KAAK,CAAC,kBAAkB,IAAI,SAAsBF,EAAE,IAAI,CAAC,SAAS,CAAcE,EAAE,SAAS,CAAC,SAAS,sBAAsB,CAAC,EAAE,gHAAgH,CAAC,CAAC,CAAC,CAAC,EAAeA,EAAE,KAAK,CAAC,kBAAkB,IAAI,SAAsBF,EAAE,IAAI,CAAC,SAAS,CAAcE,EAAE,SAAS,CAAC,SAAS,wBAAwB,CAAC,EAAE,kKAAkK,CAAC,CAAC,CAAC,CAAC,CAAC,CAAC,CAAC,EAAeA,EAAE,IAAI,CAAC,SAAsBA,EAAE,KAAK,CAAC,UAAU,gBAAgB,CAAC,CAAC,CAAC,CAAC,CAAC,CAAC,EAAeO,EAAuBT,EAAIC,EAAS,CAAC,SAAS,CAAcC,EAAE,KAAK,CAAC,SAAsBA,EAAE,SAAS,CAAC,SAAS,YAAY,CAAC,CAAC,CAAC,EAAeA,EAAE,IAAI,CAAC,SAAS,ujBAAujB,CAAC,EAAeA,EAAE,IAAI,CAAC,SAAS,iHAAiH,CAAC,CAAC,CAAC,CAAC,EAAeQ,EAAuBV,EAAIC,EAAS,CAAC,SAAS,CAAcC,EAAE,IAAI,CAAC,SAAsBA,EAAE,KAAK,CAAC,SAAsBA,EAAE,SAAS,CAAC,SAAS,cAAc,CAAC,CAAC,CAAC,CAAC,CAAC,EAAeA,EAAE,IAAI,CAAC,SAAS,wVAAwV,CAAC,CAAC,CAAC,CAAC,EAAeS,EAAuBT,EAAID,EAAS,CAAC,SAAsBC,EAAE,IAAI,CAAC,SAAsBF,EAAE,KAAK,CAAC,SAAS,CAAcE,EAAE,SAAS,CAAC,SAAS,WAAW,CAAC,EAAE,kCAAkC,CAAC,CAAC,CAAC,CAAC,CAAC,CAAC,EAAeU,EAAuBZ,EAAIC,EAAS,CAAC,SAAS,CAAcC,EAAE,IAAI,CAAC,SAAsBA,EAAE,KAAK,CAAC,SAAsBA,EAAE,SAAS,CAAC,SAAS,6BAA6B,CAAC,CAAC,CAAC,CAAC,CAAC,EAAeA,EAAE,IAAI,CAAC,SAAS,0IAA0I,CAAC,EAAeF,EAAE,IAAI,CAAC,SAAS,CAAcE,EAAE,KAAK,CAAC,CAAC,EAAeA,EAAE,SAAS,CAAC,SAAS,OAAO,CAAC,EAAE,wKAAqLA,EAAE,KAAK,CAAC,CAAC,EAAeA,EAAE,SAAS,CAAC,SAAS,MAAM,CAAC,EAAE,qIAAkJA,EAAE,KAAK,CAAC,CAAC,EAAeA,EAAE,SAAS,CAAC,SAAS,OAAO,CAAC,EAAE,wNAAwN,CAAC,CAAC,EAAeA,EAAE,IAAI,CAAC,SAAS,8TAA8T,CAAC,EAAeA,EAAE,IAAI,CAAC,SAAsBA,EAAE,KAAK,CAAC,SAAsBA,EAAE,SAAS,CAAC,SAAS,kCAAkC,CAAC,CAAC,CAAC,CAAC,CAAC,EAAeA,EAAE,IAAI,CAAC,SAAS,+iBAA+iB,CAAC,CAAC,CAAC,CAAC,EAAeW,EAAwBX,EAAID,EAAS,CAAC,SAAsBD,EAAE,IAAI,CAAC,SAAS,CAAcE,EAAE,SAAS,CAAC,SAAS,WAAW,CAAC,EAAE,QAAqBA,EAAE,KAAK,CAAC,SAAS,yEAAyE,CAAC,CAAC,CAAC,CAAC,CAAC,CAAC,EAAeY,EAAwBd,EAAIC,EAAS,CAAC,SAAS,CAAcC,EAAE,IAAI,CAAC,SAAsBA,EAAE,KAAK,CAAC,SAAsBA,EAAE,SAAS,CAAC,SAAS,uCAAuC,CAAC,CAAC,CAAC,CAAC,CAAC,EAAeA,EAAE,IAAI,CAAC,SAAS,sfAAsf,CAAC,CAAC,CAAC,CAAC,EAAea,EAAwBb,EAAID,EAAS,CAAC,SAAsBD,EAAE,IAAI,CAAC,SAAS,CAAcE,EAAE,SAAS,CAAC,SAAS,WAAW,CAAC,EAAE,QAAqBA,EAAE,KAAK,CAAC,SAAS,iHAAiH,CAAC,CAAC,CAAC,CAAC,CAAC,CAAC,EAAec,EAAwBhB,EAAIC,EAAS,CAAC,SAAS,CAAcC,EAAE,IAAI,CAAC,SAAsBA,EAAE,KAAK,CAAC,SAAsBA,EAAE,SAAS,CAAC,SAAS,+BAA+B,CAAC,CAAC,CAAC,CAAC,CAAC,EAAeA,EAAE,IAAI,CAAC,SAAS,6jBAA6jB,CAAC,EAAeA,EAAE,IAAI,CAAC,SAAsBA,EAAE,KAAK,CAAC,SAAsBA,EAAE,SAAS,CAAC,SAAS,+CAA+C,CAAC,CAAC,CAAC,CAAC,CAAC,EAAeA,EAAE,IAAI,CAAC,SAAS,saAAsa,CAAC,EAAeA,EAAE,IAAI,CAAC,SAAsBA,EAAE,KAAK,CAAC,SAAsBA,EAAE,SAAS,CAAC,SAAS,YAAY,CAAC,CAAC,CAAC,CAAC,CAAC,EAAeA,EAAE,IAAI,CAAC,SAAS,0YAA0Y,CAAC,CAAC,CAAC,CAAC,EAAee,EAAwBjB,EAAIC,EAAS,CAAC,SAAS,CAAcC,EAAE,IAAI,CAAC,SAAsBA,EAAE,SAAS,CAAC,SAAS,cAAc,CAAC,CAAC,CAAC,EAAeA,EAAE,IAAI,CAAC,SAAS,+YAA+Y,CAAC,EAAeA,EAAE,IAAI,CAAC,SAAS,4eAA4e,CAAC,EAAeA,EAAE,IAAI,CAAC,SAAsBA,EAAE,SAAS,CAAC,SAAS,wBAAwB,CAAC,CAAC,CAAC,EAAeA,EAAE,IAAI,CAAC,SAAS,6QAA6Q,CAAC,EAAeA,EAAE,IAAI,CAAC,SAAsBA,EAAE,SAAS,CAAC,SAAS,oCAAoC,CAAC,CAAC,CAAC,EAAeA,EAAE,IAAI,CAAC,SAAS,2KAA2K,CAAC,EAAeA,EAAE,IAAI,CAAC,SAAS,yOAAyO,CAAC,EAAeA,EAAE,IAAI,CAAC,SAAsBA,EAAE,SAAS,CAAC,SAAS,yBAAyB,CAAC,CAAC,CAAC,EAAeA,EAAE,IAAI,CAAC,SAAS,uCAAuC,CAAC,EAAeF,EAAE,KAAK,CAAC,SAAS,CAAcE,EAAE,KAAK,CAAC,kBAAkB,IAAI,SAAsBA,EAAE,IAAI,CAAC,SAAS,gDAAgD,CAAC,CAAC,CAAC,EAAeA,EAAE,KAAK,CAAC,kBAAkB,IAAI,SAAsBA,EAAE,IAAI,CAAC,SAAS,0CAA0C,CAAC,CAAC,CAAC,EAAeA,EAAE,KAAK,CAAC,kBAAkB,IAAI,SAAsBA,EAAE,IAAI,CAAC,SAAS,uDAAuD,CAAC,CAAC,CAAC,EAAeA,EAAE,KAAK,CAAC,kBAAkB,IAAI,SAAsBA,EAAE,IAAI,CAAC,SAAS,8CAA8C,CAAC,CAAC,CAAC,EAAeA,EAAE,KAAK,CAAC,kBAAkB,IAAI,SAAsBA,EAAE,IAAI,CAAC,SAAS,0BAA0B,CAAC,CAAC,CAAC,CAAC,CAAC,CAAC,CAAC,CAAC,CAAC,EAAegB,EAAwBhB,EAAID,EAAS,CAAC,SAAsBC,EAAE,IAAI,CAAC,SAAsBF,EAAE,KAAK,CAAC,SAAS,CAAcE,EAAE,SAAS,CAAC,SAAS,UAAU,CAAC,EAAE,sKAAsK,CAAC,CAAC,CAAC,CAAC,CAAC,CAAC,EAAeiB,EAAwBnB,EAAIC,EAAS,CAAC,SAAS,CAAcC,EAAE,IAAI,CAAC,SAAsBA,EAAE,SAAS,CAAC,SAAS,wCAAwC,CAAC,CAAC,CAAC,EAAeA,EAAE,IAAI,CAAC,SAAS,8ZAA8Z,CAAC,CAAC,CAAC,CAAC,EAAekB,EAAwBlB,EAAID,EAAS,CAAC,SAAsBC,EAAE,IAAI,CAAC,SAAsBF,EAAE,KAAK,CAAC,SAAS,CAAcE,EAAE,SAAS,CAAC,SAAS,UAAU,CAAC,EAAE,wSAAwS,CAAC,CAAC,CAAC,CAAC,CAAC,CAAC,EAAemB,EAAwBnB,EAAID,EAAS,CAAC,SAAsBC,EAAE,IAAI,CAAC,SAAS,gjBAAgjB,CAAC,CAAC,CAAC,EAAeoB,EAAwBpB,EAAID,EAAS,CAAC,SAAsBC,EAAE,IAAI,CAAC,SAAsBF,EAAE,KAAK,CAAC,SAAS,CAAcE,EAAE,SAAS,CAAC,SAAS,UAAU,CAAC,EAAE,uHAAuH,CAAC,CAAC,CAAC,CAAC,CAAC,CAAC,EAAeqB,EAAwBvB,EAAIC,EAAS,CAAC,SAAS,CAAcC,EAAE,IAAI,CAAC,SAAsBA,EAAE,SAAS,CAAC,SAAS,oDAAoD,CAAC,CAAC,CAAC,EAAeA,EAAE,IAAI,CAAC,SAAS,oQAAoQ,CAAC,EAAeA,EAAE,IAAI,CAAC,SAAsBA,EAAE,SAAS,CAAC,SAAS,mBAAmB,CAAC,CAAC,CAAC,EAAeA,EAAE,IAAI,CAAC,SAAS,mVAAmV,CAAC,EAAeA,EAAE,IAAI,CAAC,SAAsBA,EAAE,SAAS,CAAC,SAAS,gCAAgC,CAAC,CAAC,CAAC,EAAeA,EAAE,IAAI,CAAC,SAAS,uIAAuI,CAAC,CAAC,CAAC,CAAC,EAAesB,EAAwBtB,EAAID,EAAS,CAAC,SAAsBC,EAAE,IAAI,CAAC,SAAS,ouBAA+tB,CAAC,CAAC,CAAC,EAAeuB,EAAwBzB,EAAIC,EAAS,CAAC,SAAS,CAAcC,EAAE,IAAI,CAAC,SAAS,6RAA6R,CAAC,EAAeA,EAAE,KAAK,CAAC,SAAS,oCAA+B,CAAC,EAAeA,EAAE,IAAI,CAAC,SAAS,wPAAwP,CAAC,EAAeA,EAAE,IAAI,CAAC,SAAS,sPAAsP,CAAC,CAAC,CAAC,CAAC,EAAewB,EAAwB1B,EAAIC,EAAS,CAAC,SAAS,CAAcC,EAAE,IAAI,CAAC,SAAS,0IAAqI,CAAC,EAAeA,EAAE,IAAI,CAAC,SAAsBA,EAAE,KAAK,CAAC,UAAU,gBAAgB,CAAC,CAAC,CAAC,EAAeA,EAAE,KAAK,CAAC,SAAS,oBAAoB,CAAC,EAAeA,EAAE,KAAK,CAAC,SAAS,uBAAuB,CAAC,CAAC,CAAC,CAAC,EAAeyB,EAAwB3B,EAAIC,EAAS,CAAC,SAAS,CAAcC,EAAE,KAAK,CAAC,SAAS,UAAU,CAAC,EAAeA,EAAE,IAAI,CAAC,SAAS,8bAA8b,CAAC,EAAeA,EAAE,IAAI,CAAC,SAAS,iqBAAupB,CAAC,EAAeA,EAAE,IAAI,CAAC,SAAS,o8BAAo8B,CAAC,EAAeA,EAAE,MAAM,CAAC,IAAI,oCAAoC,UAAU,eAAe,oBAAoB,qFAAqF,qBAAqB,MAAM,oBAAoB,MAAM,OAAO,MAAM,IAAI,kFAAkF,OAAO,8LAA8L,MAAM,CAAC,YAAY,WAAW,EAAE,MAAM,KAAK,CAAC,EAAeA,EAAE,KAAK,CAAC,SAAS,uGAAuG,CAAC,EAAeA,EAAE,KAAK,CAAC,SAAS,0BAA0B,CAAC,EAAeA,EAAE,IAAI,CAAC,SAAS,qgBAAqgB,CAAC,EAAeA,EAAE,IAAI,CAAC,SAAS,oWAA+V,CAAC,EAAeA,EAAE,IAAI,CAAC,SAAS,qQAAgQ,CAAC,EAAeA,EAAE,MAAM,CAAC,IAAI,0BAA0B,UAAU,eAAe,oBAAoB,iFAAiF,qBAAqB,MAAM,oBAAoB,MAAM,OAAO,MAAM,IAAI,uEAAuE,OAAO,wKAAwK,MAAM,CAAC,YAAY,WAAW,EAAE,MAAM,KAAK,CAAC,EAAeA,EAAE,KAAK,CAAC,SAAS,mFAAmF,CAAC,EAAeA,EAAE,KAAK,CAAC,SAAS,SAAS,CAAC,EAAeA,EAAE,IAAI,CAAC,SAAS,yiBAAyiB,CAAC,EAAeA,EAAE,IAAI,CAAC,SAAS,2EAA2E,CAAC,EAAeA,EAAE,IAAI,CAAC,SAAsBA,EAAEI,EAAE,CAAC,KAAK,wKAAwK,OAAO,YAAY,aAAa,GAAG,aAAa,GAAG,SAAsBJ,EAAE,IAAI,CAAC,SAAS,gCAA2B,CAAC,CAAC,CAAC,CAAC,CAAC,EAAeA,EAAE,IAAI,CAAC,SAAsBA,EAAEI,EAAE,CAAC,KAAK,wKAAwK,OAAO,YAAY,aAAa,GAAG,aAAa,GAAG,SAAsBJ,EAAE,IAAI,CAAC,SAAS,4BAAuB,CAAC,CAAC,CAAC,CAAC,CAAC,CAAC,CAAC,CAAC,EAAe0B,EAAwB5B,EAAIC,EAAS,CAAC,SAAS,CAAcD,EAAE,IAAI,CAAC,SAAS,CAAC,+JAA6JE,EAAEI,EAAE,CAAC,KAAK,4DAA4D,OAAO,YAAY,aAAa,GAAG,aAAa,GAAG,SAAsBJ,EAAE,IAAI,CAAC,SAAS,uBAAuB,CAAC,CAAC,CAAC,EAAE,gZAAmZA,EAAEI,EAAE,CAAC,KAAK,gEAAgE,OAAO,YAAY,aAAa,GAAG,aAAa,GAAG,SAAsBJ,EAAE,IAAI,CAAC,SAAS,kFAAkF,CAAC,CAAC,CAAC,EAAE,wJAAwJ,CAAC,CAAC,EAAeF,EAAE,KAAK,CAAC,MAAM,CAAC,qBAAqB,OAAO,0BAA0B,QAAQ,sBAAsB,kBAAkB,0BAA0B,MAAM,EAAE,SAAS,CAAcE,EAAE,KAAK,CAAC,kBAAkB,IAAI,SAAsBA,EAAE,IAAI,CAAC,SAAS,qEAAqE,CAAC,CAAC,CAAC,EAAeA,EAAE,KAAK,CAAC,kBAAkB,IAAI,SAAsBA,EAAE,IAAI,CAAC,SAAS,0BAA0B,CAAC,CAAC,CAAC,EAAeA,EAAE,KAAK,CAAC,kBAAkB,IAAI,SAAsBA,EAAE,IAAI,CAAC,SAAS,iEAAiE,CAAC,CAAC,CAAC,EAAeA,EAAE,KAAK,CAAC,kBAAkB,IAAI,SAAsBA,EAAE,IAAI,CAAC,SAAS,uCAAuC,CAAC,CAAC,CAAC,EAAeA,EAAE,KAAK,CAAC,kBAAkB,IAAI,SAAsBA,EAAE,IAAI,CAAC,SAAS,gEAAgE,CAAC,CAAC,CAAC,EAAeA,EAAE,KAAK,CAAC,kBAAkB,IAAI,SAAsBA,EAAE,IAAI,CAAC,SAAS,kCAAkC,CAAC,CAAC,CAAC,EAAeA,EAAE,KAAK,CAAC,kBAAkB,IAAI,SAAsBA,EAAE,IAAI,CAAC,SAAS,iDAAiD,CAAC,CAAC,CAAC,EAAeA,EAAE,KAAK,CAAC,kBAAkB,IAAI,SAAsBA,EAAE,IAAI,CAAC,SAAS,gDAAgD,CAAC,CAAC,CAAC,CAAC,CAAC,CAAC,EAAeF,EAAE,IAAI,CAAC,SAAS,CAAC,+TAAuUE,EAAEI,EAAE,CAAC,KAAK,oIAAoI,OAAO,YAAY,aAAa,GAAG,aAAa,GAAG,SAAsBJ,EAAE,IAAI,CAAC,SAAS,8BAA8B,CAAC,CAAC,CAAC,EAAE,mIAAmI,CAAC,CAAC,EAAeA,EAAE,IAAI,CAAC,SAAS,0jBAAgjB,CAAC,EAAeA,EAAE,MAAM,CAAC,IAAI,GAAG,UAAU,eAAe,oBAAoB,4DAA4D,qBAAqB,MAAM,oBAAoB,MAAM,OAAO,KAAK,IAAI,qEAAqE,MAAM,CAAC,YAAY,WAAW,EAAE,MAAM,KAAK,CAAC,EAAeA,EAAE,IAAI,CAAC,SAAS,siBAA4hB,CAAC,EAAeA,EAAE,IAAI,CAAC,SAAS,uGAAuG,CAAC,EAAeA,EAAE,KAAK,CAAC,SAAS,sBAAsB,CAAC,EAAeF,EAAE,KAAK,CAAC,MAAM,CAAC,qBAAqB,OAAO,0BAA0B,QAAQ,sBAAsB,kBAAkB,0BAA0B,MAAM,EAAE,SAAS,CAAcE,EAAE,KAAK,CAAC,kBAAkB,IAAI,SAAsBA,EAAE,IAAI,CAAC,SAAS,sCAAsC,CAAC,CAAC,CAAC,EAAeA,EAAE,KAAK,CAAC,kBAAkB,IAAI,SAAsBA,EAAE,IAAI,CAAC,SAAS,qDAAqD,CAAC,CAAC,CAAC,EAAeA,EAAE,KAAK,CAAC,kBAAkB,IAAI,SAAsBA,EAAE,IAAI,CAAC,SAAS,qEAAqE,CAAC,CAAC,CAAC,EAAeF,EAAE,KAAK,CAAC,kBAAkB,IAAI,SAAS,CAAcE,EAAE,IAAI,CAAC,SAAS,6DAA6D,CAAC,EAAeF,EAAE,KAAK,CAAC,SAAS,CAAcE,EAAE,KAAK,CAAC,kBAAkB,IAAI,SAAsBA,EAAE,IAAI,CAAC,SAAS,wDAAwD,CAAC,CAAC,CAAC,EAAeA,EAAE,KAAK,CAAC,kBAAkB,IAAI,SAAsBA,EAAE,IAAI,CAAC,SAAS,2EAA2E,CAAC,CAAC,CAAC,CAAC,CAAC,CAAC,CAAC,CAAC,CAAC,CAAC,CAAC,CAAC,EAAeA,EAAE,MAAM,CAAC,IAAI,GAAG,UAAU,eAAe,oBAAoB,8DAA8D,qBAAqB,MAAM,oBAAoB,MAAM,OAAO,MAAM,IAAI,uEAAuE,MAAM,CAAC,YAAY,WAAW,EAAE,MAAM,KAAK,CAAC,EAAeF,EAAE,IAAI,CAAC,SAAS,CAAC,6FAA2FE,EAAEI,EAAE,CAAC,KAAK,wGAAwG,OAAO,YAAY,aAAa,GAAG,aAAa,GAAG,SAAsBJ,EAAE,IAAI,CAAC,SAAS,2BAA2B,CAAC,CAAC,CAAC,EAAE,iWAA4V,CAAC,CAAC,EAAeA,EAAE,IAAI,CAAC,SAAS,gZAAiY,CAAC,EAAeA,EAAE,IAAI,CAAC,SAAS,0SAA0S,CAAC,CAAC,CAAC,CAAC,EAAe2B,EAAwB7B,EAAIC,EAAS,CAAC,SAAS,CAAcC,EAAE,IAAI,CAAC,SAAS,ojCAAojC,CAAC,EAAeA,EAAE,IAAI,CAAC,SAAS,qcAAqc,CAAC,EAAeA,EAAE,IAAI,CAAC,SAAS,2sBAA2sB,CAAC,EAAeA,EAAE,MAAM,CAAC,IAAI,GAAG,UAAU,eAAe,oBAAoB,4DAA4D,qBAAqB,MAAM,oBAAoB,MAAM,OAAO,MAAM,IAAI,qEAAqE,MAAM,CAAC,YAAY,WAAW,EAAE,MAAM,IAAI,CAAC,EAAeA,EAAE,IAAI,CAAC,SAAS,6UAA6U,CAAC,EAAeA,EAAE,IAAI,CAAC,SAAS,sSAAsS,CAAC,EAAeA,EAAE,IAAI,CAAC,SAAS,gjBAAgjB,CAAC,EAAeA,EAAE,IAAI,CAAC,SAAS,snBAAsnB,CAAC,EAAeA,EAAE,IAAI,CAAC,SAAS,gsBAAgsB,CAAC,EAAeA,EAAE,IAAI,CAAC,SAAsBA,EAAE,KAAK,CAAC,UAAU,gBAAgB,CAAC,CAAC,CAAC,EAAeA,EAAE,KAAK,CAAC,SAAS,kHAAkH,CAAC,EAAeA,EAAE,KAAK,CAAC,SAAS,cAAc,CAAC,CAAC,CAAC,CAAC,EAAe4B,EAAwB9B,EAAIC,EAAS,CAAC,SAAS,CAAcC,EAAE,IAAI,CAAC,SAAS,8uBAA8uB,CAAC,EAAeA,EAAE,IAAI,CAAC,SAAsBA,EAAE,SAAS,CAAC,SAAS,wBAAwB,CAAC,CAAC,CAAC,EAAeA,EAAE,IAAI,CAAC,SAAS,gVAAgV,CAAC,EAAeF,EAAE,KAAK,CAAC,MAAM,CAAC,qBAAqB,OAAO,0BAA0B,QAAQ,sBAAsB,kBAAkB,0BAA0B,MAAM,EAAE,SAAS,CAAcE,EAAE,KAAK,CAAC,kBAAkB,IAAI,SAAsBA,EAAE,IAAI,CAAC,SAAS,iTAA4S,CAAC,CAAC,CAAC,EAAeA,EAAE,KAAK,CAAC,kBAAkB,IAAI,SAAsBA,EAAE,IAAI,CAAC,SAAS,qMAAgM,CAAC,CAAC,CAAC,CAAC,CAAC,CAAC,EAAeA,EAAE,IAAI,CAAC,SAAS,kMAAkM,CAAC,EAAeA,EAAE,MAAM,CAAC,IAAI,GAAG,UAAU,eAAe,oBAAoB,6DAA6D,qBAAqB,MAAM,oBAAoB,MAAM,OAAO,MAAM,IAAI,sEAAsE,MAAM,CAAC,YAAY,WAAW,EAAE,MAAM,KAAK,CAAC,EAAeA,EAAE,IAAI,CAAC,SAAsBA,EAAE,SAAS,CAAC,SAAS,4BAA4B,CAAC,CAAC,CAAC,EAAeA,EAAE,IAAI,CAAC,SAAS,mUAAmU,CAAC,EAAeF,EAAE,KAAK,CAAC,MAAM,CAAC,qBAAqB,OAAO,0BAA0B,QAAQ,sBAAsB,kBAAkB,0BAA0B,MAAM,EAAE,SAAS,CAAcE,EAAE,KAAK,CAAC,kBAAkB,IAAI,SAAsBA,EAAE,IAAI,CAAC,SAAS,YAAY,CAAC,CAAC,CAAC,EAAeA,EAAE,KAAK,CAAC,kBAAkB,IAAI,SAAsBA,EAAE,IAAI,CAAC,SAAS,iBAAiB,CAAC,CAAC,CAAC,EAAeA,EAAE,KAAK,CAAC,kBAAkB,IAAI,SAAsBA,EAAE,IAAI,CAAC,SAAS,eAAe,CAAC,CAAC,CAAC,EAAeA,EAAE,KAAK,CAAC,kBAAkB,IAAI,SAAsBA,EAAE,IAAI,CAAC,SAAS,aAAa,CAAC,CAAC,CAAC,EAAeA,EAAE,KAAK,CAAC,kBAAkB,IAAI,SAAsBA,EAAE,IAAI,CAAC,SAAS,mBAAmB,CAAC,CAAC,CAAC,EAAeA,EAAE,KAAK,CAAC,kBAAkB,IAAI,SAAsBA,EAAE,IAAI,CAAC,SAAS,sBAAsB,CAAC,CAAC,CAAC,EAAeA,EAAE,KAAK,CAAC,kBAAkB,IAAI,SAAsBA,EAAE,IAAI,CAAC,SAAS,mBAAmB,CAAC,CAAC,CAAC,CAAC,CAAC,CAAC,EAAeA,EAAE,IAAI,CAAC,SAAS,uXAAuX,CAAC,EAAeA,EAAE,MAAM,CAAC,IAAI,GAAG,UAAU,eAAe,oBAAoB,6DAA6D,qBAAqB,MAAM,oBAAoB,MAAM,OAAO,KAAK,IAAI,sEAAsE,MAAM,CAAC,YAAY,WAAW,EAAE,MAAM,IAAI,CAAC,EAAeA,EAAE,IAAI,CAAC,SAAS,2cAA2c,CAAC,EAAeA,EAAE,IAAI,CAAC,SAAS,6cAA6c,CAAC,EAAeA,EAAE,MAAM,CAAC,IAAI,GAAG,UAAU,eAAe,oBAAoB,2DAA2D,qBAAqB,MAAM,oBAAoB,MAAM,OAAO,MAAM,IAAI,oEAAoE,MAAM,CAAC,YAAY,WAAW,EAAE,MAAM,IAAI,CAAC,EAAeA,EAAE,IAAI,CAAC,SAAS,mkBAA8jB,CAAC,EAAeA,EAAE,IAAI,CAAC,SAAS,2gBAA2gB,CAAC,EAAeA,EAAE,IAAI,CAAC,SAAS,MAAM,CAAC,EAAeA,EAAE,KAAK,CAAC,SAAS,mHAAmH,CAAC,EAAeA,EAAE,KAAK,CAAC,SAAS,cAAc,CAAC,CAAC,CAAC,CAAC,EAAe6B,EAAwB/B,EAAIC,EAAS,CAAC,SAAS,CAAcC,EAAE,IAAI,CAAC,SAAS,0eAA0e,CAAC,EAAeA,EAAE,IAAI,CAAC,SAAS,wWAAwW,CAAC,EAAeF,EAAE,KAAK,CAAC,SAAS,CAAcE,EAAE,KAAK,CAAC,kBAAkB,IAAI,SAAsBA,EAAE,IAAI,CAAC,SAAS,0BAA0B,CAAC,CAAC,CAAC,EAAeA,EAAE,KAAK,CAAC,kBAAkB,IAAI,SAAsBA,EAAE,IAAI,CAAC,SAAS,iBAAiB,CAAC,CAAC,CAAC,EAAeA,EAAE,KAAK,CAAC,kBAAkB,IAAI,SAAsBA,EAAE,IAAI,CAAC,SAAS,wBAAwB,CAAC,CAAC,CAAC,EAAeA,EAAE,KAAK,CAAC,kBAAkB,IAAI,SAAsBA,EAAE,IAAI,CAAC,SAAS,yBAAyB,CAAC,CAAC,CAAC,EAAeA,EAAE,KAAK,CAAC,kBAAkB,IAAI,SAAsBA,EAAE,IAAI,CAAC,SAAS,eAAe,CAAC,CAAC,CAAC,EAAeA,EAAE,KAAK,CAAC,kBAAkB,IAAI,SAAsBA,EAAE,IAAI,CAAC,SAAS,uBAAuB,CAAC,CAAC,CAAC,CAAC,CAAC,CAAC,EAAeA,EAAE,IAAI,CAAC,SAAsBA,EAAE,SAAS,CAAC,SAAS,0BAA0B,CAAC,CAAC,CAAC,EAAeA,EAAE,IAAI,CAAC,SAAS,gMAAgM,CAAC,EAAeA,EAAE,IAAI,CAAC,SAAsBA,EAAE,SAAS,CAAC,SAAS,iBAAiB,CAAC,CAAC,CAAC,EAAeA,EAAE,IAAI,CAAC,SAAS,2NAA2N,CAAC,EAAeA,EAAE,IAAI,CAAC,SAAsBA,EAAE,SAAS,CAAC,SAAS,yBAAyB,CAAC,CAAC,CAAC,EAAeA,EAAE,IAAI,CAAC,SAAS,kNAAkN,CAAC,EAAeA,EAAE,IAAI,CAAC,SAAsBA,EAAE,SAAS,CAAC,SAAS,eAAe,CAAC,CAAC,CAAC,EAAeA,EAAE,IAAI,CAAC,SAAS,oOAAoO,CAAC,EAAeA,EAAE,IAAI,CAAC,SAAsBA,EAAE,SAAS,CAAC,SAAS,uBAAuB,CAAC,CAAC,CAAC,EAAeA,EAAE,IAAI,CAAC,SAAS,0HAA0H,CAAC,EAAeA,EAAE,IAAI,CAAC,SAAsBA,EAAE,SAAS,CAAC,SAAS,eAAe,CAAC,CAAC,CAAC,EAAeA,EAAE,IAAI,CAAC,SAAS,ueAAue,CAAC,EAAeA,EAAE,IAAI,CAAC,SAAS,uqBAAuqB,CAAC,EAAeA,EAAE,IAAI,CAAC,SAAS,0jBAA0jB,CAAC,EAAeA,EAAE,KAAK,CAAC,SAAS,qGAAqG,CAAC,EAAeA,EAAE,KAAK,CAAC,SAAS,uBAAuB,CAAC,CAAC,CAAC,CAAC,EAAe8B,EAAwBhC,EAAIC,EAAS,CAAC,SAAS,CAAcC,EAAE,IAAI,CAAC,SAAS,2cAA2c,CAAC,EAAeF,EAAE,KAAK,CAAC,SAAS,CAAcE,EAAE,KAAK,CAAC,kBAAkB,IAAI,SAAsBA,EAAE,IAAI,CAAC,SAAS,mBAAmB,CAAC,CAAC,CAAC,EAAeA,EAAE,KAAK,CAAC,kBAAkB,IAAI,SAAsBA,EAAE,IAAI,CAAC,SAAS,0BAA0B,CAAC,CAAC,CAAC,EAAeA,EAAE,KAAK,CAAC,kBAAkB,IAAI,SAAsBA,EAAE,IAAI,CAAC,SAAS,iBAAiB,CAAC,CAAC,CAAC,EAAeA,EAAE,KAAK,CAAC,kBAAkB,IAAI,SAAsBA,EAAE,IAAI,CAAC,SAAS,0BAA0B,CAAC,CAAC,CAAC,EAAeA,EAAE,KAAK,CAAC,kBAAkB,IAAI,SAAsBA,EAAE,IAAI,CAAC,SAAS,eAAe,CAAC,CAAC,CAAC,CAAC,CAAC,CAAC,EAAeA,EAAE,IAAI,CAAC,SAAsBA,EAAE,SAAS,CAAC,SAAS,sBAAsB,CAAC,CAAC,CAAC,EAAeA,EAAE,IAAI,CAAC,SAAS,uNAAuN,CAAC,EAAeF,EAAE,KAAK,CAAC,SAAS,CAAcE,EAAE,KAAK,CAAC,kBAAkB,IAAI,SAAsBA,EAAE,IAAI,CAAC,SAAS,8CAA8C,CAAC,CAAC,CAAC,EAAeA,EAAE,KAAK,CAAC,kBAAkB,IAAI,SAAsBA,EAAE,IAAI,CAAC,SAAS,mDAAmD,CAAC,CAAC,CAAC,EAAeA,EAAE,KAAK,CAAC,kBAAkB,IAAI,SAAsBA,EAAE,IAAI,CAAC,SAAS,uCAAuC,CAAC,CAAC,CAAC,EAAeA,EAAE,KAAK,CAAC,kBAAkB,IAAI,SAAsBA,EAAE,IAAI,CAAC,SAAS,oCAAoC,CAAC,CAAC,CAAC,EAAeA,EAAE,KAAK,CAAC,kBAAkB,IAAI,SAAsBA,EAAE,IAAI,CAAC,SAAS,qCAAqC,CAAC,CAAC,CAAC,EAAeA,EAAE,KAAK,CAAC,kBAAkB,IAAI,SAAsBA,EAAE,IAAI,CAAC,SAAS,oDAA0C,CAAC,CAAC,CAAC,CAAC,CAAC,CAAC,CAAC,CAAC,CAAC,EAAe+B,EAAwBjC,EAAIC,EAAS,CAAC,SAAS,CAAcC,EAAE,IAAI,CAAC,SAAsBA,EAAE,SAAS,CAAC,SAAS,eAAe,CAAC,CAAC,CAAC,EAAeA,EAAE,IAAI,CAAC,SAAS,gdAAgd,CAAC,EAAeA,EAAE,IAAI,CAAC,SAAsBA,EAAE,KAAK,CAAC,UAAU,gBAAgB,CAAC,CAAC,CAAC,EAAeA,EAAE,IAAI,CAAC,SAAsBA,EAAE,SAAS,CAAC,SAAS,sBAAsB,CAAC,CAAC,CAAC,EAAeA,EAAE,IAAI,CAAC,SAAS,sOAAsO,CAAC,EAAeF,EAAE,KAAK,CAAC,SAAS,CAAcE,EAAE,KAAK,CAAC,kBAAkB,IAAI,SAAsBA,EAAE,IAAI,CAAC,SAAS,QAAQ,CAAC,CAAC,CAAC,EAAeA,EAAE,KAAK,CAAC,kBAAkB,IAAI,SAAsBA,EAAE,IAAI,CAAC,SAAS,oDAAoD,CAAC,CAAC,CAAC,EAAeA,EAAE,KAAK,CAAC,kBAAkB,IAAI,SAAsBA,EAAE,IAAI,CAAC,SAAS,iCAAiC,CAAC,CAAC,CAAC,EAAeA,EAAE,KAAK,CAAC,kBAAkB,IAAI,SAAsBA,EAAE,IAAI,CAAC,SAAS,wBAAwB,CAAC,CAAC,CAAC,CAAC,CAAC,CAAC,EAAeA,EAAE,IAAI,CAAC,SAAS,6TAA6T,CAAC,CAAC,CAAC,CAAC,EAAegC,EAAwBlC,EAAIC,EAAS,CAAC,SAAS,CAAcC,EAAE,IAAI,CAAC,SAAsBA,EAAE,SAAS,CAAC,SAAS,yBAAyB,CAAC,CAAC,CAAC,EAAeA,EAAE,IAAI,CAAC,SAAS,ydAAod,CAAC,CAAC,CAAC,CAAC,EAAeiC,EAAwBnC,EAAIC,EAAS,CAAC,SAAS,CAAcC,EAAE,IAAI,CAAC,SAAsBA,EAAE,SAAS,CAAC,SAAS,2BAA2B,CAAC,CAAC,CAAC,EAAeA,EAAE,IAAI,CAAC,SAAS,wWAAwW,CAAC,EAAeF,EAAE,KAAK,CAAC,SAAS,CAAcE,EAAE,KAAK,CAAC,kBAAkB,IAAI,SAAsBA,EAAE,IAAI,CAAC,SAAS,sIAAsI,CAAC,CAAC,CAAC,EAAeA,EAAE,KAAK,CAAC,kBAAkB,IAAI,SAAsBA,EAAE,IAAI,CAAC,SAAS,4FAA4F,CAAC,CAAC,CAAC,EAAeA,EAAE,KAAK,CAAC,kBAAkB,IAAI,SAAsBA,EAAE,IAAI,CAAC,SAAS,qGAAqG,CAAC,CAAC,CAAC,CAAC,CAAC,CAAC,CAAC,CAAC,CAAC,EAAekC,EAAwBpC,EAAIC,EAAS,CAAC,SAAS,CAAcD,EAAE,IAAI,CAAC,SAAS,CAAC,gCAA6CE,EAAEI,EAAE,CAAC,KAAK,4BAA4B,OAAO,YAAY,aAAa,GAAG,aAAa,GAAG,SAAsBJ,EAAE,IAAI,CAAC,SAAS,YAAY,CAAC,CAAC,CAAC,EAAE,0GAAuHA,EAAE,KAAK,CAAC,SAAS,gCAAgC,CAAC,EAAE,mCAAgDA,EAAEI,EAAE,CAAC,KAAK,oDAAoD,OAAO,YAAY,aAAa,GAAG,aAAa,GAAG,SAAsBJ,EAAE,IAAI,CAAC,SAAS,gEAAgE,CAAC,CAAC,CAAC,EAAE,uNAAoOA,EAAE,KAAK,CAAC,SAAS,aAAa,CAAC,EAAE,gEAAgE,CAAC,CAAC,EAAeA,EAAE,MAAM,CAAC,IAAI,GAAG,UAAU,eAAe,oBAAoB,6DAA6D,qBAAqB,MAAM,oBAAoB,MAAM,OAAO,KAAK,IAAI,sEAAsE,MAAM,CAAC,YAAY,WAAW,EAAE,MAAM,KAAK,CAAC,EAAeA,EAAE,IAAI,CAAC,SAAS,2pCAAipC,CAAC,EAAeA,EAAE,MAAM,CAAC,IAAI,GAAG,UAAU,eAAe,oBAAoB,8DAA8D,qBAAqB,MAAM,oBAAoB,MAAM,OAAO,MAAM,IAAI,uEAAuE,MAAM,CAAC,YAAY,WAAW,EAAE,MAAM,IAAI,CAAC,EAAeF,EAAE,IAAI,CAAC,SAAS,CAAC,4pBAAyqBE,EAAE,KAAK,CAAC,SAAS,WAAW,CAAC,EAAE,0KAAuLA,EAAE,KAAK,CAAC,SAAS,WAAW,CAAC,EAAE,yVAAyV,CAAC,CAAC,CAAC,CAAC,CAAC,EAAemC,EAAwBrC,EAAIC,EAAS,CAAC,SAAS,CAAcC,EAAE,MAAM,CAAC,IAAI,GAAG,UAAU,eAAe,oBAAoB,8DAA8D,qBAAqB,MAAM,oBAAoB,MAAM,OAAO,KAAK,IAAI,uEAAuE,MAAM,CAAC,YAAY,WAAW,EAAE,MAAM,IAAI,CAAC,EAAeA,EAAE,IAAI,CAAC,SAAS,2XAA2X,CAAC,EAAeA,EAAE,IAAI,CAAC,SAAS,sPAAsP,CAAC,EAAeA,EAAE,MAAM,CAAC,IAAI,GAAG,UAAU,eAAe,oBAAoB,8DAA8D,qBAAqB,KAAK,oBAAoB,MAAM,OAAO,KAAK,IAAI,uEAAuE,MAAM,CAAC,YAAY,UAAU,EAAE,MAAM,KAAK,CAAC,EAAeF,EAAE,IAAI,CAAC,SAAS,CAAcE,EAAEI,EAAE,CAAC,KAAK,+BAA+B,OAAO,YAAY,aAAa,GAAG,aAAa,GAAG,SAAsBJ,EAAE,IAAI,CAAC,SAAS,kBAAkB,CAAC,CAAC,CAAC,EAAE,mkBAAglBA,EAAE,KAAK,CAAC,SAAS,4CAA4C,CAAC,EAAE,2pBAA2pB,CAAC,CAAC,EAAeA,EAAE,KAAK,CAAC,SAAsBA,EAAE,KAAK,CAAC,SAAsBA,EAAE,SAAS,CAAC,SAAS,8CAAoC,CAAC,CAAC,CAAC,CAAC,CAAC,EAAeA,EAAE,KAAK,CAAC,SAAS,4CAA4C,CAAC,EAAeA,EAAE,MAAM,CAAC,IAAI,GAAG,UAAU,eAAe,oBAAoB,2DAA2D,qBAAqB,MAAM,oBAAoB,OAAO,OAAO,MAAM,IAAI,oEAAoE,OAAO,8PAA8P,MAAM,CAAC,YAAY,YAAY,EAAE,MAAM,KAAK,CAAC,EAAeA,EAAE,IAAI,CAAC,SAAS,wgCAAmgC,CAAC,EAAeA,EAAE,IAAI,CAAC,SAAsBA,EAAE,KAAK,CAAC,SAAS,0MAA0M,CAAC,CAAC,CAAC,CAAC,CAAC,CAAC,EAAeoC,EAAwBtC,EAAIC,EAAS,CAAC,SAAS,CAAcC,EAAE,MAAM,CAAC,IAAI,GAAG,UAAU,eAAe,oBAAoB,8DAA8D,qBAAqB,MAAM,oBAAoB,MAAM,OAAO,KAAK,IAAI,uEAAuE,MAAM,CAAC,YAAY,WAAW,EAAE,MAAM,IAAI,CAAC,EAAeF,EAAE,IAAI,CAAC,SAAS,CAAC,8BAA2CE,EAAEI,EAAE,CAAC,KAAK,yBAAyB,OAAO,YAAY,aAAa,GAAG,aAAa,GAAG,SAAsBJ,EAAE,IAAI,CAAC,SAAS,qBAAqB,CAAC,CAAC,CAAC,EAAE,gIAA6IA,EAAEI,EAAE,CAAC,KAAK,mJAAmJ,OAAO,YAAY,aAAa,GAAG,aAAa,GAAG,SAAsBJ,EAAE,IAAI,CAAC,SAAS,oCAAoC,CAAC,CAAC,CAAC,EAAE,sCAAmDA,EAAEI,EAAE,CAAC,KAAK,4DAA4D,OAAO,YAAY,aAAa,GAAG,aAAa,GAAG,SAAsBJ,EAAE,IAAI,CAAC,SAAS,yCAAoC,CAAC,CAAC,CAAC,EAAE,yMAAyM,CAAC,CAAC,EAAeA,EAAE,MAAM,CAAC,IAAI,GAAG,UAAU,eAAe,oBAAoB,6DAA6D,qBAAqB,MAAM,oBAAoB,MAAM,OAAO,KAAK,IAAI,sEAAsE,OAAO,sKAAsK,MAAM,CAAC,YAAY,WAAW,EAAE,MAAM,KAAK,CAAC,EAAeA,EAAE,MAAM,CAAC,IAAI,GAAG,UAAU,eAAe,oBAAoB,8DAA8D,qBAAqB,MAAM,oBAAoB,MAAM,OAAO,MAAM,IAAI,uEAAuE,OAAO,wKAAwK,MAAM,CAAC,YAAY,WAAW,EAAE,MAAM,KAAK,CAAC,EAAeF,EAAE,IAAI,CAAC,SAAS,CAAcE,EAAEI,EAAE,CAAC,KAAK,sCAAsC,OAAO,YAAY,aAAa,GAAG,aAAa,GAAG,SAAsBJ,EAAE,IAAI,CAAC,SAAS,YAAY,CAAC,CAAC,CAAC,EAAE,4yBAAuyB,CAAC,CAAC,EAAeA,EAAE,IAAI,CAAC,SAAS,6yBAA6yB,CAAC,EAAeA,EAAE,MAAM,CAAC,IAAI,GAAG,UAAU,eAAe,oBAAoB,8DAA8D,qBAAqB,MAAM,oBAAoB,OAAO,OAAO,MAAM,IAAI,uEAAuE,OAAO,yKAAyK,MAAM,CAAC,YAAY,YAAY,EAAE,MAAM,KAAK,CAAC,EAAeA,EAAE,IAAI,CAAC,SAAS,guBAAstB,CAAC,EAAeA,EAAE,MAAM,CAAC,IAAI,GAAG,UAAU,eAAe,oBAAoB,6DAA6D,qBAAqB,MAAM,oBAAoB,OAAO,OAAO,MAAM,IAAI,sEAAsE,OAAO,uKAAuK,MAAM,CAAC,YAAY,YAAY,EAAE,MAAM,KAAK,CAAC,EAAeA,EAAE,IAAI,CAAC,SAAS,0vBAAqvB,CAAC,EAAeA,EAAE,IAAI,CAAC,SAAS,uRAAuR,CAAC,EAAeA,EAAE,IAAI,CAAC,SAAS,gZAAsY,CAAC,EAAeA,EAAE,IAAI,CAAC,SAAS,6LAA6L,CAAC,CAAC,CAAC,CAAC,EAAeqC,EAAwBvC,EAAIC,EAAS,CAAC,SAAS,CAAcC,EAAE,MAAM,CAAC,IAAI,GAAG,UAAU,eAAe,oBAAoB,8DAA8D,qBAAqB,MAAM,oBAAoB,OAAO,OAAO,MAAM,IAAI,uEAAuE,OAAO,yKAAyK,MAAM,CAAC,YAAY,YAAY,EAAE,MAAM,KAAK,CAAC,EAAeA,EAAE,IAAI,CAAC,SAAS,w0BAAw0B,CAAC,EAAeA,EAAE,MAAM,CAAC,IAAI,GAAG,UAAU,eAAe,oBAAoB,6DAA6D,qBAAqB,MAAM,oBAAoB,MAAM,OAAO,KAAK,IAAI,sEAAsE,MAAM,CAAC,YAAY,WAAW,EAAE,MAAM,KAAK,CAAC,EAAeA,EAAE,IAAI,CAAC,SAAS,iuBAAiuB,CAAC,EAAeA,EAAE,MAAM,CAAC,IAAI,GAAG,UAAU,eAAe,oBAAoB,8DAA8D,qBAAqB,MAAM,oBAAoB,MAAM,OAAO,MAAM,IAAI,uEAAuE,OAAO,wKAAwK,MAAM,CAAC,YAAY,WAAW,EAAE,MAAM,KAAK,CAAC,EAAeA,EAAE,IAAI,CAAC,SAAS,qqBAAqqB,CAAC,EAAeA,EAAE,IAAI,CAAC,SAAS,s5BAAs5B,CAAC,EAAeA,EAAE,IAAI,CAAC,SAAS,yTAAyT,CAAC,EAAeF,EAAE,IAAI,CAAC,SAAS,CAAC,mdAAgeE,EAAEI,EAAE,CAAC,KAAK,yBAAyB,OAAO,YAAY,aAAa,GAAG,aAAa,GAAG,SAAsBJ,EAAE,IAAI,CAAC,SAAS,2BAA2B,CAAC,CAAC,CAAC,EAAE,uEAAuE,CAAC,CAAC,CAAC,CAAC,CAAC,EAAesC,EAAwBxC,EAAIC,EAAS,CAAC,SAAS,CAAcC,EAAE,KAAK,CAAC,SAAS,kOAAkO,CAAC,EAAeA,EAAE,MAAM,CAAC,IAAI,GAAG,UAAU,eAAe,oBAAoB,4DAA4D,qBAAqB,MAAM,oBAAoB,MAAM,OAAO,MAAM,IAAI,qEAAqE,OAAO,oKAAoK,MAAM,CAAC,YAAY,WAAW,EAAE,MAAM,KAAK,CAAC,EAAeF,EAAE,IAAI,CAAC,SAAS,CAAC,mdAAgeE,EAAEI,EAAE,CAAC,KAAK,4BAA4B,OAAO,YAAY,aAAa,GAAG,aAAa,GAAG,SAAsBJ,EAAE,IAAI,CAAC,SAAS,gBAAgB,CAAC,CAAC,CAAC,EAAE,qMAAkNA,EAAEI,EAAE,CAAC,KAAK,0BAA0B,OAAO,YAAY,aAAa,GAAG,aAAa,GAAG,SAAsBJ,EAAE,IAAI,CAAC,SAAS,SAAS,CAAC,CAAC,CAAC,EAAE,iBAA8BA,EAAEI,EAAE,CAAC,KAAK,2CAA2C,OAAO,YAAY,aAAa,GAAG,aAAa,GAAG,SAAsBJ,EAAE,IAAI,CAAC,SAAS,uBAAuB,CAAC,CAAC,CAAC,EAAE,4FAA4F,CAAC,CAAC,EAAeA,EAAE,MAAM,CAAC,IAAI,GAAG,UAAU,eAAe,oBAAoB,8DAA8D,qBAAqB,MAAM,oBAAoB,MAAM,OAAO,MAAM,IAAI,uEAAuE,OAAO,wKAAwK,MAAM,CAAC,YAAY,WAAW,EAAE,MAAM,KAAK,CAAC,EAAeF,EAAE,IAAI,CAAC,SAAS,CAAC,ooBAA4oBE,EAAEI,EAAE,CAAC,KAAK,uDAAuD,OAAO,YAAY,aAAa,GAAG,aAAa,GAAG,SAAsBJ,EAAE,IAAI,CAAC,SAAS,aAAa,CAAC,CAAC,CAAC,EAAE,iEAAiE,CAAC,CAAC,EAAeA,EAAE,MAAM,CAAC,IAAI,GAAG,UAAU,eAAe,oBAAoB,8DAA8D,qBAAqB,MAAM,oBAAoB,MAAM,OAAO,MAAM,IAAI,uEAAuE,MAAM,CAAC,YAAY,WAAW,EAAE,MAAM,KAAK,CAAC,EAAeA,EAAE,IAAI,CAAC,SAAS,+xBAA+xB,CAAC,EAAeA,EAAE,MAAM,CAAC,IAAI,GAAG,UAAU,eAAe,oBAAoB,6DAA6D,qBAAqB,MAAM,oBAAoB,MAAM,OAAO,MAAM,IAAI,sEAAsE,MAAM,CAAC,YAAY,WAAW,EAAE,MAAM,KAAK,CAAC,EAAeF,EAAE,IAAI,CAAC,SAAS,CAAC,8MAA2NE,EAAEI,EAAE,CAAC,KAAK,uDAAuD,OAAO,YAAY,aAAa,GAAG,aAAa,GAAG,SAAsBJ,EAAE,IAAI,CAAC,SAAS,aAAa,CAAC,CAAC,CAAC,EAAE,qUAAgU,CAAC,CAAC,EAAeA,EAAE,IAAI,CAAC,SAAS,oWAAoW,CAAC,CAAC,CAAC,CAAC,EACzxmGuC,EAAqB,CAAC,QAAU,CAAC,UAAY,CAAC,KAAO,WAAW,YAAc,CAAC,sBAAwB,GAAG,CAAC,EAAE,UAAY,CAAC,KAAO,WAAW,YAAc,CAAC,sBAAwB,GAAG,CAAC,EAAE,WAAa,CAAC,KAAO,WAAW,YAAc,CAAC,sBAAwB,GAAG,CAAC,EAAE,WAAa,CAAC,KAAO,WAAW,YAAc,CAAC,sBAAwB,GAAG,CAAC,EAAE,WAAa,CAAC,KAAO,WAAW,YAAc,CAAC,sBAAwB,GAAG,CAAC,EAAE,SAAW,CAAC,KAAO,WAAW,YAAc,CAAC,sBAAwB,GAAG,CAAC,EAAE,WAAa,CAAC,KAAO,WAAW,YAAc,CAAC,sBAAwB,GAAG,CAAC,EAAE,WAAa,CAAC,KAAO,WAAW,YAAc,CAAC,sBAAwB,GAAG,CAAC,EAAE,WAAa,CAAC,KAAO,WAAW,YAAc,CAAC,sBAAwB,GAAG,CAAC,EAAE,UAAY,CAAC,KAAO,WAAW,YAAc,CAAC,sBAAwB,GAAG,CAAC,EAAE,WAAa,CAAC,KAAO,WAAW,YAAc,CAAC,sBAAwB,GAAG,CAAC,EAAE,WAAa,CAAC,KAAO,WAAW,YAAc,CAAC,sBAAwB,GAAG,CAAC,EAAE,WAAa,CAAC,KAAO,WAAW,YAAc,CAAC,sBAAwB,GAAG,CAAC,EAAE,UAAY,CAAC,KAAO,WAAW,YAAc,CAAC,sBAAwB,GAAG,CAAC,EAAE,WAAa,CAAC,KAAO,WAAW,YAAc,CAAC,sBAAwB,GAAG,CAAC,EAAE,WAAa,CAAC,KAAO,WAAW,YAAc,CAAC,sBAAwB,GAAG,CAAC,EAAE,UAAY,CAAC,KAAO,WAAW,YAAc,CAAC,sBAAwB,GAAG,CAAC,EAAE,WAAa,CAAC,KAAO,WAAW,YAAc,CAAC,sBAAwB,GAAG,CAAC,EAAE,WAAa,CAAC,KAAO,WAAW,YAAc,CAAC,sBAAwB,GAAG,CAAC,EAAE,WAAa,CAAC,KAAO,WAAW,YAAc,CAAC,sBAAwB,GAAG,CAAC,EAAE,UAAY,CAAC,KAAO,WAAW,YAAc,CAAC,sBAAwB,GAAG,CAAC,EAAE,WAAa,CAAC,KAAO,WAAW,YAAc,CAAC,sBAAwB,GAAG,CAAC,EAAE,WAAa,CAAC,KAAO,WAAW,YAAc,CAAC,sBAAwB,GAAG,CAAC,EAAE,WAAa,CAAC,KAAO,WAAW,YAAc,CAAC,sBAAwB,GAAG,CAAC,EAAE,WAAa,CAAC,KAAO,WAAW,YAAc,CAAC,sBAAwB,GAAG,CAAC,EAAE,WAAa,CAAC,KAAO,WAAW,YAAc,CAAC,sBAAwB,GAAG,CAAC,EAAE,UAAY,CAAC,KAAO,WAAW,YAAc,CAAC,sBAAwB,GAAG,CAAC,EAAE,WAAa,CAAC,KAAO,WAAW,YAAc,CAAC,sBAAwB,GAAG,CAAC,EAAE,UAAY,CAAC,KAAO,WAAW,YAAc,CAAC,sBAAwB,GAAG,CAAC,EAAE,WAAa,CAAC,KAAO,WAAW,YAAc,CAAC,sBAAwB,GAAG,CAAC,EAAE,WAAa,CAAC,KAAO,WAAW,YAAc,CAAC,sBAAwB,GAAG,CAAC,EAAE,WAAa,CAAC,KAAO,WAAW,YAAc,CAAC,sBAAwB,GAAG,CAAC,EAAE,WAAa,CAAC,KAAO,WAAW,YAAc,CAAC,sBAAwB,GAAG,CAAC,EAAE,WAAa,CAAC,KAAO,WAAW,YAAc,CAAC,sBAAwB,GAAG,CAAC,EAAE,UAAY,CAAC,KAAO,WAAW,YAAc,CAAC,sBAAwB,GAAG,CAAC,EAAE,WAAa,CAAC,KAAO,WAAW,YAAc,CAAC,sBAAwB,GAAG,CAAC,EAAE,WAAa,CAAC,KAAO,WAAW,YAAc,CAAC,sBAAwB,GAAG,CAAC,EAAE,WAAa,CAAC,KAAO,WAAW,YAAc,CAAC,sBAAwB,GAAG,CAAC,EAAE,mBAAqB,CAAC,KAAO,UAAU,CAAC,CAAC",
  "names": ["richText", "u", "x", "p", "richText1", "richText2", "richText3", "Link", "richText4", "richText5", "richText6", "richText7", "richText8", "richText9", "richText10", "richText11", "richText12", "richText13", "richText14", "richText15", "richText16", "richText17", "richText18", "richText19", "richText20", "richText21", "richText22", "richText23", "richText24", "richText25", "richText26", "richText27", "richText28", "richText29", "richText30", "richText31", "richText32", "richText33", "richText34", "richText35", "richText36", "richText37", "__FramerMetadata__"]
}